Protein Alignment Frl and FMNL3

DIOPT Version :9

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: XP_011537270.1
• Gene: FMNL3 / 91010
• HGNCID: 23698
• Length: 1047
• Species: Homo sapiens
• Alignment Length: 1142
• Identity: 469/1142 - (41%)
• Similarity: 663/1142 - (58%)
• Gaps: 182/1142 - (15%)

  Fly    57 GCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQE 121
            ||.   .::..||       ..|.....||      :||:||||||:|||.||:|||||:|||||
Human    42 GCG---PYILWPS-------AFPPASSGDR------SSMNLPPDKARLLRQYDNEKKWDLICDQE 90

  Fly   122 MVQAKDPPSHYLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEW 186
            ..|.|:||..|:.||:::|||..:|.          :.|:.|.|  ||:|||:||||||||||.|
Human    91 RFQVKNPPHTYIQKLQSFLDPSVTRK----------KFRRRVQE--STKVLRELEISLRTNHIGW 143

  Fly   187 VKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPG 251
            |:|||:|.|:|||.|||||||             ..|:                ||.:...:..|
Human   144 VREFLNDENKGLDVLVDYLSF-------------AQCS----------------VMFDFEGLESG 179

  Fly   252 GGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSP---SLKRRSRH--------- 304
            .                :|..|..:..:.|...|:|  ..||.:|   ||.|.:|.
Human   180 D----------------DGAFDKLRSWSRSIEDLQP--PSALSAPFTNSLARSARQSVLRYSTLP 226

  Fly   305 ----IAKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLEL 365
                :....:.:..||:||.|:|||||||.:||||:|:.|..|:|.|||||.:|:.|||||||||
Human   227 GRRALKNSRLVSQKDDVHVCILCLRAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLEL 291

  Fly   366 LAAICLVKGGHEIILGSFDNFKDVCQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVED 430
            |||:|||:|||||||.:|||||:||:|..||:.|||||.| |..|||||||||||:|||||||||
Human   292 LAAVCLVRGGHEIILAAFDNFKEVCKELHRFEKLMEYFRN-EDSNIDFMVACMQFINIVVHSVED 355

  Fly   431 MNYRVHLQYEFTALGLDKYLERIRLTESEELKVQISAYLDNVFDVAALMEDSETKTSALERVQEL 495
            ||:|||||||||.|||:::|::.|.||||:|:|||.|||||||||..|:||:|||..|||:|:||
Human   356 MNFRVHLQYEFTKLGLEEFLQKSRHTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEEL 420

  Fly   496 EDQL----EREIDRNSEFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHNEQELK 556
            |:.:    |:.:|..:|.:.:.||||.:.|..:.|.|.:....:....::..::|:::..|:..:
Human   421 EEHVSHLTEKLLDLENENMMRVAELEKQLLQREKELESIKETYENTSHQVHTLRRLIKEKEEAFQ 485

  Fly   557 KRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSGAASLTLPPPPPPMPASPTASSA 621
            :|        ..|:...|.|....|.....:....|..|.......|..|.|||         ..
Human   486 RR--------CHLEPNVRGLESVDSEALARVGPAELSEGMPPSDLDLLAPAPPP---------EE 533

  Fly   622 APPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPD---- 682
            ..|.|||||||.|||||                |.|...        ||.||:.|..|:..
Human   534 VLPLPPPPAPPLPPPPP----------------PLPDKC--------PPAPPLPGAAPSVVLTVG 574

  Fly   683 -GAMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRN 746
             .|:.||:.:.||::||..||.||||||:.||:|:|||||||.:.:|.::|||.||        .
Human   575 LSAIRIKKPIKTKFRLPVFNWTALKPNQISGTVFSELDDEKILEDLDLDKFEELFK--------T 631

  Fly   747 GSNGTEVDGSLQSSKRF-KRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLEN 810
            .:.|..:|.....:|.. |....|:|||..|.:|:||:.||.|...:::..|||:.||:.|.::.
Human   632 KAQGPALDLICSKNKTAQKAASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDF 696

  Fly   811 VELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHL 875
            ||.|.:.:||:||||..::|..||:..:.|..||:|||..|:|||::.::|.|.::|||.|::.:
Human   697 VECLMRFLPTEAEVKLLRQYERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQM 761

  Fly   876 ISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKSTDKRSS 940
            ::||:.:|..||.|:|.|:|.|.:|||:||.|||:||:|||..|||||||||.|:||||||::.:
Human   762 LTPQLNAIIAASASVKSSQKLKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMT 826

  Fly   941 LLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTH 1005
            |||:|..|::.|:|:|.||..||:..:|||:|:||||:.||:||.:||:|:|:|..:.    ...
Human   827 LLHFIALTVKEKYPDLANFWHELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIH----DNS 887

  Fly  1006 ILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENE 1070
            :||:||:.:|.||.|::.|.:.|:||:...|.|||:|.:....:.||.:.|||.|::|:.:||||
Human   888 VLRNFLSTNEGKLDKLQRDAKTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENE 952

  Fly  1071 QRLRLEKAAALAASKKENDQVLMRNKVNQKKQQL----PSNGALSLQEAVINELKSKAHSVREKK 1131
            .|             |:.::|:...::.|:.::|    ||......|:.:|.||       |.::
Human   953 AR-------------KKQEEVMREKQLAQEAKKLDAKTPSQRNKWQQQELIAEL-------RRRQ 997

  Fly  1132 LLQQDEVY---NGALEDILLGLKSEPYRRADAVRRSQ 1165
            ..:...||   :|.:|||:..|||.|:....|.|.|:
Human   998 AKEHRPVYEGKDGTIEDIITVLKSVPFTARTAKRGSR 1034

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	126/309 (41%)
		Drf_FH3	374..567	CDD:283917	103/196 (53%)
		FH2	687..1063	CDD:280362	170/376 (45%)
FMNL3	XP_011537270.1	Drf_GBD	64..297	CDD:283920	122/291 (42%)
		Drf_FH3	300..497	CDD:283917	105/205 (51%)
		FH2	580..945	CDD:280362	170/376 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156505
Domainoid	1	1.000	342	1.000	Domainoid score	I1072
eggNOG	1	0.900	-	-		E1_KOG1923
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	849	1.000	Inparanoid score	I436
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54599
OrthoDB	1	1.010	-	-		D149905at33208
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		oto90469
orthoMCL	1	0.900	-	-		OOG6_103315
Panther	1	1.100	-	-	O	PTHR45857
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	1	1.000	-	-		X513
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800