Protein Alignment Frl and BNI1

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_014128.2
• Gene: BNI1 / 855450
• SGDID: S000005215
• Length: 1953
• Species: Saccharomyces cerevisiae
• Alignment Length: 955
• Identity: 204/955 - (21%)
• Similarity: 355/955 - (37%)
• Gaps: 274/955 - (28%)

  Fly   384 DNFKDVCQEKR--RFQTLMEYFMNFEAFNIDFMVACMQFMNIV------VHSVEDMNYRVHLQYE 440
            :...::..||:  ..:.|.|....::.|.|||.|.  :.|:..      |.:.||.||
Yeast   954 ERVNELFNEKKSLALKRLKELETKYKGFGIDFNVD--EIMDSPKKNTGDVETEEDANY------- 1009

  Fly   441 FTALGLDKYLERIRLTESEELKVQISAYLDNVFDVAA-------LMEDSETKTSALERVQELEDQ 498
               ..||....:.:|.|       |:...|.:.|:..       :.||.|:..|:.....|.| :
Yeast  1010 ---ASLDPKTYQKKLDE-------INRITDQLLDIQTQTEHEIQVEEDGESDLSSSSSDDESE-E 1063

  Fly   499 LEREIDRNSEFLYKYAELES--------ESLTLKTEREQ----------------LAMIRQKLEE 539
            :.::.....|...:::||.|        ::|:.|....|                :..:..|:|:
Yeast  1064 IYQDASPTQELRSEHSELSSGSGPGSFLDALSQKYGTGQNVTASAAFGENNNGSGIGPLHSKVEK 1128

  Fly   540 ELTVMQRM----------LQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGS-------- 586
              |.|.|:          |:...|::.|.:.  :.:|.:.....:|||.::::...|
Yeast  1129 --TFMNRLRKSTVSSAPYLEELTQKVNKVEP--YEQNEDEGLDKKSLPENSTASAASAFDKAEKD 1189

  Fly   587 ----LANG--GLMA----------------GSTSGAASLTL------------PPPPPPMPA--- 614
                :.||  |.:.                .:|.||..|:.            ||||||:||
Yeast  1190 MRQHVENGKQGRVVNHEEDKTADFSAVSKLNNTDGAEDLSTQSSVLSSQPPPPPPPPPPVPAKLF 1254

  Fly   615 -----------------SPTASSAAPPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPP 662
                             ..|..|.|||||||     |||||..:..|.|.|.    .|.||..|.
Yeast  1255 GESLEKEKKSEDDTVKQETTGDSPAPPPPPP-----PPPPPPMALFGKPKGE----TPPPPPLPS 1310

  Fly   663 MLSSFQ----PPPPPVAGFMPAPD--GAMT---------IKRKVPTKY-KLPTLNWIAL--KPNQ 709
            :|||..    ||.||:   |||..  .|:|         :..|.|..: ||..|:|..|  ..|.
Yeast  1311 VLSSSTDGVIPPAPPM---MPASQIKSAVTSPLLPQSPSLFEKYPRPHKKLKQLHWEKLDCTDNS 1372

  Fly   710 VRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRFKRPDNVSLLEH 774
            :.||       .|..|..|     :.::.|:...|.......|:. || :|||.:....::.|..
Yeast  1373 IWGT-------GKAEKFAD-----DLYEKGVLADLEKAFAAREIK-SL-ASKRKEDLQKITFLSR 1423

  Fly   775 TRLRNIAISRRKL-GMPIDDVIAAIHSLDLKKLSLEN-VELLQKMVPTDAEV---KSYKEYIIE- 833
            ...:...|:.... .:.:.|::..|.:.|...|...: ||.|.|....:..|   ::|..|..:
Yeast  1424 DISQQFGINLHMYSSLSVADLVKKILNCDRDFLQTPSVVEFLSKSEIIEVSVNLARNYAPYSTDW 1488

  Fly   834 ------------RKDQQLLTEEDKFMLQLS-RVERI-SSKLAIMNYMGNFVDSVHLISPQVQSIA 884
                        .||...|...|:..|||. .:|.. .|::..:..:.::....:.:..:::.:.
Yeast  1489 EGVRNLEDAKPPEKDPNDLQRADQIYLQLMVNLESYWGSRMRALTVVTSYEREYNELLAKLRKVD 1553

  Fly   885 GASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATI 949
            .|.::|::|...:.|..::||.||::|...: .|.||||.:|..|...|.|....:.|:|:...:
Yeast  1554 KAVSALQESDNLRNVFNVILAVGNFMNDTSK-QAQGFKLSTLQRLTFIKDTTNSMTFLNYVEKIV 1617

  Fly   950 RAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAEL----------------- 997
            |..:|...:|.|||........|::|.:|.|.::..:.:..|.:..|:
Yeast  1618 RLNYPSFNDFLSELEPVLDVVKVSIEQLVNDCKDFSQSIVNVERSVEIGNLSDSSKFHPLDKVLI 1682

  Fly   998 ---------RVKGAQTHILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADA-AAFF 1052
                     |.||       |.|   ||::|....:       |:..:..:|:.|.:..| .:||
Yeast  1683 KTLPVLPEARKKG-------DLL---EDEVKLTIME-------FESLMHTYGEDSGDKFAKISFF 1730

  Fly  1053 ALIVRFTRAFKQHDQEN-----EQRLRL---------EKAAALAASKKENDQVLMRNKVNQKKQQ 1103
            .....|...:|:...:|     |:||.:         :|.|.....:|||.    .:..::..::
Yeast  1731 KKFADFINEYKKAQAQNLAAEEEERLYIKHKKIVEEQQKRAQEKEKQKENS----NSPSSEGNEE 1791

  Fly  1104 LPSNGALSLQEAVINELKS------------KAHSVREKKLLQQD 1136
            ..:....::.:.::.:||:            |...||:|.|.::|
Yeast  1792 DEAEDRRAVMDKLLEQLKNAGPAKSDPSSARKRALVRKKYLSEKD 1836

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886
		Drf_FH3	374..567	CDD:461885	43/231 (19%)
		FH2	687..1063	CDD:396655	90/425 (21%)
BNI1	NP_014128.2	Drf_GBD	178..458	CDD:461886
		Drf_FH3	511..707	CDD:461885
		PTZ00491	<690..801	CDD:240439
		FH2	1348..1741	CDD:396655	90/424 (21%)
		PTZ00121	<1739..1841	CDD:173412	18/102 (18%)