Protein Alignment Frl and BNR1

DIOPT Version :9

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_012107.1
• Gene: BNR1 / 854647
• SGDID: S000001421
• Length: 1375
• Species: Saccharomyces cerevisiae
• Alignment Length: 1412
• Identity: 270/1412 - (19%)
• Similarity: 497/1412 - (35%)
• Gaps: 417/1412 - (29%)

  Fly    38 HNGSISSG------TLQKQDLRYDIGCSSQ-YQHVRQPSLRSRSQQPMPTTDELDRRFAKVLASM 95
            ::|.:::|      .|:||      |..|. |...:..|....|..|| .::|::.      :.|
Yeast    37 NDGLVAAGLQLVGVALEKQ------GTGSHIYMKQKNFSANDVSSSPM-VSEEVNG------SEM 88

  Fly    96 D-----LPPDKAKLLRNYDD---------------------EKKWDMIC---------------- 118
            |     :|.|.:.:.|.:|:                     .:||.:||
Yeast    89 DFNPKCMPQDASLVERMFDELLKDGTFFWGAAYKNLQNISLRRKWLLICKIRSSNHWGKKKVTSS 153

  Fly   119 --------DQEMVQAKDPPSHYLSKLRTYLDPKASR-SHRLYLFYFLCQKRKMVG---------- 164
                    ..|:.:    .:|:|..|...|.....: |..||......:|:..:.
Yeast   154 TTYSTHLATNELAE----NAHFLDGLVRNLSTGGMKLSKALYKLEKFLRKQSFLQLFLKDEIYLT 214

  Fly   165 ---ESTSTQVLRDLEI---------------SLRTNH----IEWVKEFLDDTNQGLDALVDYLSF 207
               |.|...:.::|:.               .:|..|    |.|..|.|.|.|..|..  ..||.
Yeast   215 TLIEKTLPLISKELQFVYLRCFKILMNNPLARIRALHSEPLIRWFTELLTDQNSNLKC--QLLSM 277

  Fly   208 RLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGG--------GGGLLSHG---- 260
            .|.::                |....|..|.|::....|.:....        ...:..|.
Yeast   278 ELLLL----------------LTYVEGSTGCELIWDQLSILFTDWLEWFDKILADDIAIHSSLYL 326

  Fly   261 ---------NSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDD 316
                     ::|...|.|..|.         ||...|..:.|:  .||:.:.|.....:..|..|
Yeast   327 NWNQLKIDYSTTFLLLINSILQ---------GFNNKTALEILN--FLKKNNIHNTITFLELAYKD 380

  Fly   317 IHVSIMCLRAIMNNKYG----FNMVIQ-----------------HREAI---NCIALSLIHKSLR 357
            ...|::.:..|...|..    |:.:|:                 ..|.:   ||:.|..  |...
Yeast   381 DPNSVVIMEQIKQFKSKESAIFDSMIKTTNDTNSLHPTKDIARIESEPLCLENCLLLKA--KDSP 443

  Fly   358 TKALVLELLAAICLVKGGHEIILGSFDNFKDVCQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMN 422
            .:|.:.|::.::..       ||.|...:.:..:..:...:|:.|.::      .|.|:.....:
Yeast   444 VEAPINEIIQSLWK-------ILDSQKPYSESIKLLKLINSLLFYLID------SFQVSTNPSFD 495

  Fly   423 IVVHSVEDMNY--RVHLQYEFTALGLDKYLERIRLTESEELKVQISAYLDNVFDVA--------- 476
            ..:.|.|:::|  :..:.....:|..|: :.|..:||.::|..:|| :|:...::.
Yeast   496 ETLESAENVDYVFQDSVNKLLDSLQSDE-IARRAVTEIDDLNAKIS-HLNEKLNLVENHDKDHLI 558

  Fly   477 ALMEDSET----KTSALERVQELEDQLEREIDRNSEFLYKYAE---LESESLTL----------- 523
            |.:::||:    ||..:|.::......::.:|:.:.....|.:   |.|.:|::
Yeast   559 AKLDESESLISLKTKEIENLKLQLKATKKRLDQITTHQRLYDQPPSLASSNLSIAGSIIKNNSHG 623

  Fly   524 --------KTEREQLAMIRQKLEEELTVMQRML--------------QHNEQELKKRDTLL---- 562
                    |.:::|..:...|....|...:|:.              ..||.|.|.:|:|.
Yeast   624 NIIFQNLAKKQQQQQKISLPKRSTSLLKSKRVTSLSSYLTDANNENESQNESEDKSKDSLFQRST 688

  Fly   563 --------------HTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSGAASL---------- 603
                          :.:|:.|.::...|..|.|.|.........:..|.|.:..|
Yeast   689 STINFNIPSMKNITNMQNVSLNSILSELEFSNSLGTQPNYQSSPVLSSVSSSPKLFPRLSSDSLD 753

  Fly   604 -------------TLPPPPPPMPASPTASS---------------AAPPPPP------------- 627
                         .|||||||.|..|...|               |||.|||
Yeast   754 NGIQLVPEVVKLPQLPPPPPPPPPPPLPQSLLTEAEAKPDGVSCIAAPAPPPLPDLFKTKTCGAV 818

  Fly   628 PPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPDGAMTIKRKVP 692
            ||.||.||.|...|....||.....|.|:||....:|||......|....:..|          |
Yeast   819 PPPPPPPPLPESLSMNKGPSNHDLVTPPAPPLPNGLLSSSSVSINPTTTDLKPP----------P 873

  Fly   693 TKYKLPTLNWIALKPNQVRGTIF----------NELDDEKIFKQIDFNEFEERFKIGIGGALRNG 747
            |:.:|..::|.  |...::.|::          .||..:.||.||     |:.||:.....:.|.
Yeast   874 TEKRLKQIHWD--KVEDIKDTLWEDTFQRQETIKELQTDGIFSQI-----EDIFKMKSPTKIANK 931

  Fly   748 SNG-TEVDGSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENV 811
            .|. :.:..|..:.|.......:|.|.....:...|:...... :.|:...:..|:.....::||
Yeast   932 RNAESSIALSSNNGKSSNELKKISFLSRDLAQQFGINLHMFSQ-LSDMEFVMKVLNCDNDIVQNV 995

  Fly   812 ELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERI----------------SSKL 860
            .:|:..  ...|:.:..:.::.:.:.....::.|.:..|.|.:||                .|.|
Yeast   996 NILKFF--CKEELVNIPKSMLNKYEPYSQGKDGKAVSDLQRADRIFLELCINLRFYWNARSKSLL 1058

  Fly   861 AIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQS 925
            .:..|..::.|.:.    ::|.|..|.:.|.:|.|||:::.|:...||::  ||| ...|.||:|
Yeast  1059 TLSTYERDYYDLIF----KLQKIDDAISHLNRSPKFKSLMFIITEIGNHM--NKR-IVKGIKLKS 1116

  Fly   926 LDTLIDTKST-DKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGM- 988
            |..|...:|: |:..|.||:|...||.|:|::..|..:|...:....::||:|.::..|..|.:
Yeast  1117 LTKLAFVRSSIDQNVSFLHFIEKVIRIKYPDIYGFVDDLKNIEDLGKISLEHVESECHEFHKKIE 1181

  Fly   989 DLVRKEAELRVKGAQTHILRDFLNNSEDKLKKIKSDLRHAQEAFK----EC----------VEYF 1039
            |||.:....::...:.      |:..:..:||:|..:..|:...:    :|          ::|:
Yeast  1182 DLVTQFQVGKLSKEEN------LDPRDQIIKKVKFKINRAKTKSELLIGQCKLTLIDLNKLMKYY 1240

  Fly  1040 GDSSRNADAA-AFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQ 1103
            |:..::.::. .||...:.|...||:..:||.::..:|:     ..::....:.||...|:|
Yeast  1241 GEDPKDKESKNEFFQPFIEFLAMFKKCAKENIEKEEMER-----VYEQRKSLLDMRTSSNKK--- 1297

  Fly  1104 LPSNG------------ALSLQEAVINELKSKAHSVREKKLLQQDEV 1138
              |||            |:.|..:.:.|:|.....:|.:|..:.:|:
Yeast  1298 --SNGSDENDGEKVNRDAVDLLISKLREVKKDPEPLRRRKSTKLNEI 1342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	68/421 (16%)
		Drf_FH3	374..567	CDD:283917	41/261 (16%)
		FH2	687..1063	CDD:280362	88/419 (21%)
BNR1	NP_012107.1	FH2	868..1265	CDD:396655	89/429 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	88	1.000	Domainoid score	I1818
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	141	1.000	Inparanoid score	I1179
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		mtm9222
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.990