DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Frl and AFH14

DIOPT Version :9

Sequence 1:	NP_729954.2	Gene:	Frl / 39561	FlyBaseID:	FBgn0267795	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	NP_001321171.1	Gene:	AFH14 / 840068	AraportID:	AT1G31810	Length:	1230	Species:	Arabidopsis thaliana

Alignment Length:	587	Identity:	156/587 - (26%)
Similarity:	264/587 - (44%)	Gaps:	101/587 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   595 GSTSGAASLTLPPPPPPMPAS--PTASSAAPPPPPPPA--------------PPAPPPPPGF--- 640
            |||........||||||.|.:  |.|..|.|||||||.              ||.|||||..
plant   651 GSTGNKRQAQPPPPPPPPPPTRIPAAKCAPPPPPPPPTSHSGSIRVGPPSTPPPPPPPPPKANIS 715

  Fly   641 ------SPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVA---------------GFMPAPDGA 684
                  :|...|..|....||.||..||:..:..|||||::               ...|.|.||
plant   716 NAPKPPAPPPLPPSSTRLGAPPPPPPPPLSKTPAPPPPPLSKTPVPPPPPGLGRGTSSGPPPLGA 780

  Fly   685 --------------------------MTIKRKVPTKYKLPTLNWIALKPNQVRGTIF---NELDD 720
                                      :::....|.|..|..|:|..: ....:|:::   .:.::
plant   781 KGSNAPPPPPPAGRGRASLGLGRGRGVSVPTAAPKKTALKPLHWSKV-TRAAKGSLWADTQKQEN 844

  Fly   721 EKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRFKRPDNVSLLEHTRLRNIAISRR 785
            :....:||.:|.|..|. .:.......|.|       :......:|:.|.|::..|..|..|...
plant   845 QPRAPEIDISELESLFS-AVSDTTAKKSTG-------RRGSSISKPEKVQLVDLRRANNCEIMLT 901

  Fly   786 KLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQL 850
            |:.:|:.|:::|:.:||...|.::.||.|.|..||..|::..:.|   ..|:::|.:.::|.::|
plant   902 KIKIPLPDMLSAVLALDSLALDIDQVENLIKFCPTKEEMELLRNY---TGDKEMLGKCEQFFMEL 963

  Fly   851 SRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLN-SNK 914
            .:|.||.:||.:..:...|...|..:...:.:|..|:..:|:|.|.:.:::.:|..||.|| ...
plant   964 MKVPRIEAKLRVFGFKITFASQVEELKSCLNTINAATKEVKESAKLRQIMQTILTLGNALNQGTA 1028

  Fly   915 RGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVA 979
            ||.|.||||.||..|.||::.:.:.:|:||:...:..|.||||:|.::|...:.|:.:.|:.:..
plant  1029 RGSAVGFKLDSLLKLSDTRARNNKMTLMHYLCKLVGEKMPELLDFANDLVHLEAASKIELKTLAE 1093

  Fly   980 DVQELEKGMDLVRKEAELRVK---GAQT----HILRDFLNNSEDKLKKIKSDLRHAQEAFKECVE 1037
            ::|...||::.|  |.||...   ||.:    .:|::||:.:::::|.:.|..............
plant  1094 EMQAATKGLEKV--EQELMASENDGAISLGFRKVLKEFLDMADEEVKTLASLYSEVGRNADSLSH 1156

  Fly  1038 YFGDSSRNADAAAFFALIVRFTRAFKQHDQENE-----QRLRLEKAA--ALAASKK---ENDQVL 1092
            |||:............::..|.:.|.:..:|||     ::.:|||.|  ..:|:||   :||..|
plant  1157 YFGEDPARCPFEQVTKILTLFMKTFIKSREENEKQAEAEKKKLEKEAIKEKSATKKDGVDNDNDL 1221

  Fly  1093 MR 1094
            ::
plant  1222 IQ 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920
		Drf_FH3	374..567	CDD:283917
		FH2	687..1063	CDD:280362	97/386 (25%)
AFH14	NP_001321171.1	PTEN_C2	198..338	CDD:287393
AFH14	NP_001321171.1	FH2	814..1181	CDD:280362	97/380 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I2015
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X513
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.960