DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Frl and FH6

DIOPT Version :9

Sequence 1:	NP_729954.2	Gene:	Frl / 39561	FlyBaseID:	FBgn0267795	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	NP_201548.1	Gene:	FH6 / 836883	AraportID:	AT5G67470	Length:	899	Species:	Arabidopsis thaliana

Alignment Length:	585	Identity:	151/585 - (25%)
Similarity:	241/585 - (41%)	Gaps:	121/585 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   533 IRQKLEEELTVMQ-RMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGS 596
            |:|||...:.... |.|:.:||||               ..|::.|:
plant   312 IKQKLPPPVQPPPLRGLESDEQEL---------------PYSQNKPK------------------ 343

  Fly   597 TSGAASLTLPPPPP---------------PMPASPTASSAAPPPPPPPAPPAPPPPP-----GFS 641
                  .:.|||||               |.|.........|||||||.|.||||||     .|.
plant   344 ------FSQPPPPPNRAAFQAITQEKSPVPPPRRSPPPLQTPPPPPPPPPLAPPPPPQKRPRDFQ 402

  Fly   642 PLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPV----------AGFM-PAPDGAMTIKRKVPTKY 695
            .|...:.|.|:|  :...:|....:|:.|.|..          ||.: .:.||...     |:|.
plant   403 MLRKVTNSEATT--NSTTSPSRKQAFKTPSPKTKAVEEVNSVSAGSLEKSGDGDTD-----PSKP 460

  Fly   696 KLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVDGSLQSS 760
            ||..|:|..::.:..|.|::::|.....  |::.:..|..|....|.:.........|....::.
plant   461 KLKPLHWDKVRASSDRATVWDQLKSSSF--QLNEDRMEHLFGCNSGSSAPKEPVRRSVIPLAENE 523

  Fly   761 KRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVK 825
            .|        :|:..:.:||||..|.|.:..::|..|:...:.:.|..|.:|.|.||.||..|..
plant   524 NR--------VLDPKKSQNIAILLRALNVTREEVSEALTDGNPESLGAELLETLVKMAPTKEEEI 580

  Fly   826 SYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSL 890
            ..:||   ..|...|...::|:..:..:.....::..|.|..||...|..:....|::..||..|
plant   581 KLREY---SGDVSKLGTAERFLKTILDIPFAFKRVEAMLYRANFDAEVKYLRNSFQTLEEASLEL 642

  Fly   891 KQSRKFKAVLEIVLAFGNYLN-SNKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATI-RAKF 953
            |.||.|..:||.||..||.:| ...||.|..|||.:|..|:|.|..|.:::|||::|..| |::.
plant   643 KASRLFLKLLEAVLMTGNRMNVGTNRGDAIAFKLDTLLKLVDIKGVDGKTTLLHFVVQEITRSEG 707

  Fly   954 PELLNFESELYGTD----------------------KAASVALENVVADVQELEKGMDLVRKEAE 996
            ......|:.|:|.:                      |:|.:..:.:.:.|.:||.|:|.:|  :.
plant   708 TTTTKDETILHGNNDGFRKQGLQVVAGLSRDLVNVKKSAGMDFDVLSSYVTKLEMGLDKLR--SF 770

  Fly   997 LRVKGAQTHI---LRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYF-GDSSRNADAAAFFALIVR 1057
            |:.:..|...   ::.||..:|::::|||...|.|....||..||| |:::|.........::||
plant   771 LKTETTQGRFFDSMKTFLKEAEEEIRKIKGGERKALSMVKEVTEYFHGNAAREEAHPLRIFMVVR 835

Fly 1058 1057
plant 836 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920
		Drf_FH3	374..567	CDD:283917	10/34 (29%)
		FH2	687..1063	CDD:280362	105/399 (26%)
FH6	NP_201548.1	FH2	452..842	CDD:280362	107/404 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I2015
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.960