DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Frl and DIAPH3

DIOPT Version :9

Sequence 1:	NP_729954.2	Gene:	Frl / 39561	FlyBaseID:	FBgn0267795	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	NP_001035982.1	Gene:	DIAPH3 / 81624	HGNCID:	15480	Length:	1193	Species:	Homo sapiens

Alignment Length:	1208	Identity:	257/1208 - (21%)
Similarity:	477/1208 - (39%)	Gaps:	356/1208 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 PMPTTD-ELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKD---------PPSH 131
            |.|.:: ||...|.|::..|:|..||...||..|...|.:|:.......:|.         .|..
Human   114 PKPLSENELLELFEKMMEDMNLNEDKKAPLREKDFSIKKEMVMQYINTASKTGSLKRSRQISPQE 178

  Fly   132 YLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQ 196
            ::.:|:     ..|...||                  ...|..|.:||.:|.:.||:.|   .::
Human   179 FIHELK-----MGSADERL------------------VTCLESLRVSLTSNPVSWVESF---GHE 217

  Fly   197 GLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGN 261
            ||..|:|.|         |:.:.|.:   :|:
Human   218 GLGLLLDIL---------EKLISGKI---QEK--------------------------------- 237

  Fly   262 STGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRA 326
                                                       :.|.|.       |..|.||:|
Human   238 -------------------------------------------VVKKNQ-------HKVIQCLKA 252

  Fly   327 IMNNKYGFNMVIQHREAINCIALSL--IHKSLRTKALVLELLAAICLVKGGHEIILGS-FDNFKD 388
            :||.:||...::....:::.:|.::  .|.::.|.  |::||:|:|:|  |.|.||.. .:....
Human   253 LMNTQYGLERIMSEERSLSLLAKAVDPRHPNMMTD--VVKLLSAVCIV--GEESILEEVLEALTS 313

  Fly   389 VCQEKR--RFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLE 451
            ..:||:  ||..::|   .....::...|||||.:|.:|.|.:|:::|:|::.||...||.:.|.
Human   314 AGEEKKIDRFFCIVE---GLRHNSVQLQVACMQLINALVTSPDDLDFRLHIRNEFMRCGLKEILP 375

  Fly   452 RIRLTESEELKVQ---------------------ISAYLDNVFDVAALMEDSETKTSA----LER 491
            .::..:::.|.:|                     |.|.||..:||..::..:..:|.|    :..
Human   376 NLKCIKNDGLDIQLKVFDEHKEEDLFELSHRLEDIRAELDEAYDVYNMVWSTVKETRAEGYFISI 440

  Fly   492 VQEL---------EDQLEREIDR------------NSEFLYK---------YAELESESLTLKTE 526
            :|.|         ..|..:.||.            :.:|.|:         :.::..:...|:..
Human   441 LQHLLLIRNDYFIRQQYFKLIDECVSQIVLHRDGMDPDFTYRKRLDLDLTQFVDICIDQAKLEEF 505

  Fly   527 REQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRS-----------LPRSA 580
            .|:.:.:.:|.|:|.|..    |..:.||:|::..::....|||.....           ||.|.
Human   506 EEKASELYKKFEKEFTDH----QETQAELQKKEAKINELQAELQAFKSQFGALPADCNIPLPPSK 566

  Fly   581 SSGDGSLANGGLMAGSTSGAASLTLPPPPPPMPASPTASSAAPPPPPPPAPPAP----------P 635
            ..|.|..|                ||||||    .|:.....|||||||.||.|          |
Human   567 EGGTGHSA----------------LPPPPP----LPSGGGVPPPPPPPPPPPLPGMRMPFSGPVP 611

  Fly   636 PPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPDGAMTIKRKVPTKYKLPTL 700
            |||   |||                  .|.....||.|:..|...|      |::...:..:..|
Human   612 PPP---PLG------------------FLGGQNSPPLPILPFGLKP------KKEFKPEISMRRL 649

  Fly   701 NWIALKPNQVRGTIFNELDDEKIFKQIDF-----NEF----EERFKIGIGGALRNGSNGTEVDGS 756
            ||:.::|:::....|....:|..::.:|.     |.|    :||                ..:..
Human   650 NWLKIRPHEMTENCFWIKVNENKYENVDLLCKLENTFCCQQKER----------------REEED 698

  Fly   757 LQSSKRFKRP-DNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPT 820
            ::..|..|:. ..:..|:....:|::|......:|.:::...|..:|..:|:...::.|.|.:|.
Human   699 IEEKKSIKKKIKELKFLDSKIAQNLSIFLSSFRVPYEEIRMMILEVDETRLAESMIQNLIKHLPD 763

  Fly   821 DAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAG 885
            ..::.|..::   :.:...|.|.::|::.:|.|:|:..:|:.:.:...|.:.|:.|.|.:.:::.
Human   764 QEQLNSLSQF---KSEYSNLCEPEQFVVVMSNVKRLRPRLSAILFKLQFEEQVNNIKPDIMAVST 825

  Fly   886 ASTSLKQSRKFKAVLEIVLAFGNYLNSNKR-GPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATI 949
            |...:|:|:.|..:||:||..|||:|:..| ...:||.|.||..|.||||.|::::|||::|...
Human   826 ACEEIKKSKSFSKLLELVLLMGNYMNAGSRNAQTFGFNLSSLCKLKDTKSADQKTTLLHFLVEIC 890

  Fly   950 RAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTH-----ILRD 1009
            ..|:|::|||..:|...|||:.|::|.:..:::::.:.:..:.||.|........|     .:..
Human   891 EEKYPDILNFVDDLEPLDKASKVSVETLEKNLRQMGRQLQQLEKELETFPPPEDLHDKFVTKMSR 955

  Fly  1010 FLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAF---------KQH 1065
            |:.:::::.:.:.....:.::.::..:.|:....:......|...:..|...|         |:.
Human   956 FVISAKEQYETLSKLHENMEKLYQSIIGYYAIDVKKVSVEDFLTDLNNFRTTFMQAIKENIKKRE 1020

  Fly  1066 DQENEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINELKSKAHSVREK 1130
            .:|.|:|:|:.|..|    ::|      |.:..|||::|             .|:|::.
Human  1021 AEEKEKRVRIAKELA----ERE------RLERQQKKKRL-------------LEMKTEG------ 1056

  Fly  1131 KLLQQDEVYNGALEDILLGLKSEPYRRADAVRRSQRRR 1168
                 ||  .|.::::|..|:|      .|..|.:|:|
Human  1057 -----DE--TGVMDNLLEALQS------GAAFRDRRKR 1081

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	55/305 (18%)
		Drf_FH3	374..567	CDD:283917	52/250 (21%)
		FH2	687..1063	CDD:280362	84/400 (21%)
DIAPH3	NP_001035982.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..57
		Nuclear localization signal. /evidence=ECO:0000250\|UniProtKB:Q9Z207	36..60
		Drf_GBD	115..297	CDD:283920	54/304 (18%)
		Drf_FH3	305..488	CDD:283917	38/185 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	558..622		31/104 (30%)
		FH2	636..1008	CDD:280362	84/396 (21%)
		Nuclear export signal. /evidence=ECO:0000250\|UniProtKB:Q9Z207	1184..1193
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.940