Protein Alignment Frl and Daam2

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_001008232.2
• Gene: Daam2 / 76441
• MGIID: 1923691
• Length: 1115
• Species: Mus musculus
• Alignment Length: 1250
• Identity: 299/1250 - (23%)
• Similarity: 524/1250 - (41%)
• Gaps: 329/1250 - (26%)

  Fly    77 PMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDP-------PSHYLS 134
            |:|..:||:.|||:::..:||.....:.:.....||||.:.|.:...| :||       |.:|:.
Mouse    41 PIPNPEELNVRFAELVDELDLTDKNREAVFALPPEKKWQIYCSKRKEQ-EDPNKLATSWPEYYID 104

  Fly   135 KLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTS--TQVLRDLEISLRTNHIEWVKEFLDDTNQG 197
            ::..     .:....||         :...|.|.  .||:.||:.:|||..:.:|..|:|
Mouse   105 RINA-----MAAMQNLY---------ETEDEETDKRNQVVEDLKTALRTQPMRFVTRFID----- 150

  Fly   198 LDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNS 262
                                |:|:.|.    ||...|.|
Mouse   151 --------------------LEGLTCL----LNFLRGMD-------------------------- 165

  Fly   263 TGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIM-CLRA 326
                  :.|.:||                                         ||.|:: |::|
Mouse   166 ------HTTCESR-----------------------------------------IHTSLIGCIKA 183

  Fly   327 IMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDVCQ 391
            :|||..|...|:...|||:.||.||..::.:||..|||:|.|:|||.|||:.:|.:..:::....
Mouse   184 LMNNSQGRAHVLAQPEAISIIAQSLRTENSKTKVAVLEILGAVCLVPGGHKKVLQAMLHYQAYAA 248

  Fly   392 EKRRFQTLM-EYFMNFEAF--NIDFMVACMQFMNIVVHS---VEDMNYRVHLQYEFTALGLDKYL 450
            |:.|||||: |...:...:  .::...|.|.|:|.|:::   .:::.:|:||:|||..||:...:
Mouse   249 ERTRFQTLLNELDRSLGRYRDEVNLKTAIMSFINAVLNAGAGEDNLEFRLHLRYEFLMLGIQPVI 313

  Fly   451 ERIRLTESEELKVQISAY----------LDNVFDVAALMEDSETKTSALERVQE----------- 494
            :::|..|:..|...:..:          |...||:..:  |:::.:...|.:.:
Mouse   314 DKLRQHENAILDKHLDFFEMVRNEDDLELARRFDMVHI--DTKSASQMFELIHKKLKHTEAYPCL 376

  Fly   495 ---LEDQLEREIDRNSEFLYKYAELES--ESLTLKTER------------------------EQL 530
               |...|:....||..:..::..|:.  :.:.|:.||                        .::
Mouse   377 LSVLHHCLQMPYKRNGGYFQQWQLLDRILQQIVLQDERGVDPDLAPLENFNVKNIVNMLINENEV 441

  Fly   531 AMIRQKLE----EELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPR-----SASSGDGS 586
            ...|.:.|    |.:.:|.|:      |.|:|:  ..||.:|.:.:.|:|.:     :..|.:..
Mouse   442 KQWRDQAEKFRKEHMELMSRL------ERKERE--CETKTLEKEEMMRTLNKMKDKLARESQELR 498

  Fly   587 LANG---GLMAGSTSGAASLTLPPPPPPMP---ASPTASSAAPPPPPP------PAPPAPPPPPG 639
            .|.|   .|:|.....:......||||..|   :|...::..||||||      |.|||||.|||
Mouse   499 QARGQVAELVARHNESSTGPVSSPPPPGGPLTLSSSRTTNDLPPPPPPLPFDSCPPPPAPPLPPG 563

  Fly   640 FSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPDGAMTIKRKVP-TKYKLPTLNWI 703
            ..|:             ||.|||..||  .|||....|  :.:.|...|:::| ..:.|.:.||:
Mouse   564 GPPI-------------PPGAPPCFSS--GPPPSHDPF--SSNEAPLRKKRIPQPSHPLKSFNWV 611

  Fly   704 ALKPNQVRGTIFNELDDEKIFKQIDFNEFE-------------------ERFKIGIGGALRNGSN 749
            .|...:|.||::||:||.::|:.:|..:||                   ||..:..|||......
Mouse   612 KLNEERVSGTVWNEIDDSQVFRILDLEDFEKMFSAYQRHQACMQEGPQRERGNVRDGGAASRPLP 676

  Fly   750 GTEVD---------------------GSLQ----SSKRFKRPDNVSLLEHTRLRNIAISRRKLGM 789
            ..|..                     ||.:    :|::.|   .:|:::..|.:|..|...||.:
Mouse   677 AVEASAHRTEKASRSMVSATGAKKELGSTEDIYITSRKVK---ELSVIDGRRAQNCIILLSKLKL 738

  Fly   790 PIDDVIAAIHSLDLKK-LSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRV 853
            ..|::..||..:|.:: |:.:.:|.|.|.:|..:::...:|:   :.:.:.:...|:|:.::||:
Mouse   739 SNDEIRQAILRMDEQEDLAKDMLEQLLKFIPEKSDIDLLEEH---KHEIERMARADRFLYEMSRI 800

  Fly   854 ERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPA 918
            :....:|..:.:...|.:.:....|:|::|..||..|..|::.|.:||:|||.||::|..:||.|
Mouse   801 DHYQQRLQALFFKKKFQERLAEAKPKVEAILLASRELTLSQRLKQMLEVVLAIGNFMNKGQRGGA 865

  Fly   919 YGFKLQSLDTLIDTKST-DKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQ 982
            |||::.||:.:.||||: |:..|||||::..:...||::||..|||....:||.|.|..:..:|.
Mouse   866 YGFRVASLNKIADTKSSIDRNISLLHYLIMILEKHFPDILNMPSELKHLSEAAKVNLAELEKEVS 930

  Fly   983 ELEKGMDLVRKEAELRVKGAQ------THILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGD 1041
            .|.:|:..|..|.|.:...|:      ..::.||:..|.....:::..|..|::.|.:.:.:||:
Mouse   931 ILRRGLRAVEVELEYQRHQARDPNDKFVPVMSDFITVSSFSFSELEDQLNEARDKFAKALTHFGE 995

  Fly  1042 SSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPS 1106
            .........||.:...|.:||.:..|:.|...|          :||.|:...|
Mouse   996 QESKMQPDEFFGIFDTFLQAFLEARQDLEAMRR----------RKEEDERRAR------------ 1038

  Fly  1107 NGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGALE------DILLGLKSEPYRRADAVRRSQ 1165
                  .|.::.|.:.|....|::|:|.     .||||      |::..|:|......|..:..:
Mouse  1039 ------MEFMLKEQREKERWQRQRKVLA-----GGALEESGEFDDLVSALRSGEVFDKDLSKFKR 1092

  Fly  1166 RRRIDNNRLSRTLEE 1180
            .|:...:::.....|
Mouse  1093 NRKRPGSQVPEVTRE 1107

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	67/303 (22%)
		Drf_FH3	374..567	CDD:461885	50/252 (20%)
		FH2	687..1063	CDD:396655	113/428 (26%)
Daam2	NP_001008232.2	Drf_GBD	41..228	CDD:461886	67/303 (22%)
		Drf_FH3	231..435	CDD:461885	40/205 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..605		36/111 (32%)
		FH2	595..1016	CDD:396655	112/426 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	655..697		6/41 (15%)