Protein Alignment Frl and FMNL1

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_001398057.1
• Gene: FMNL1 / 752
• HGNCID: 1212
• Length: 1104
• Species: Homo sapiens
• Alignment Length: 1179
• Identity: 479/1179 - (40%)
• Similarity: 674/1179 - (57%)
• Gaps: 185/1179 - (15%)

  Fly    68 PSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHY 132
            |...:..:||||...||:.||.:.|..|:|||||.:||..||:||||::|||||..|.|:||:.|
Human    19 PKQPAPPKQPMPAAGELEERFNRALNCMNLPPDKVQLLSQYDNEKKWELICDQERFQVKNPPAAY 83

  Fly   133 LSKLRTYLDP-KASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQ 196
            :.||::|:|. ..||.........|..||::   ..||||||:||.|||||||.||:|||::.|:
Human    84 IQKLKSYVDTGGVSRKVAADWMSNLGFKRRV---QESTQVLRELETSLRTNHIGWVQEFLNEENR 145

  Fly   197 GLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGN 261
            |||.|::||:|             ..|:....:..|:.|      ..||....|
Human   146 GLDVLLEYLAF-------------AQCSVTYDMESTDNG------ASNSEKNKP----------- 180

  Fly   262 STGHGLANGTLDSRQQHTMSYGFLRPTIAD-ALDSPSLKRRSRHIA-KL------------NMGA 312
                                   |..::.| :...||...:|||:. ||            .:.:
Human   181 -----------------------LEQSVEDLSKGPPSSVPKSRHLTIKLTPAHSRKALRNSRIVS 222

  Fly   313 ATDDIHVSIMCLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHE 377
            ..||:||.|||||||||.:.||::|:.|...:|.|||||.:|:.||||||||||||:|||:|||:
Human   223 QKDDVHVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHD 287

  Fly   378 IILGSFDNFKDVCQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFT 442
            |||.:|||||:||.|:.||:.|||||.| |..|||||||||||:||||||||:||:||.||||||
Human   288 IILAAFDNFKEVCGEQHRFEKLMEYFRN-EDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFT 351

  Fly   443 ALGLDKYLERIRLTESEELKVQISAYLDNVFDVAALMEDSETKTSALERVQELEDQL----EREI 503
            .||||.||||:|||||::|:|||.|||||:|||.||:||:|||.:.||.::||::|:    ||..
Human   352 HLGLDLYLERLRLTESDKLQVQIQAYLDNIFDVGALLEDTETKNAVLEHMEELQEQVALLTERLR 416

  Fly   504 DRNSEFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHNEQE-----LKKRDTLLH 563
            |..:|.:.|.||||.:   |...|::|..:|::..|. |.|....:..|.|     ...|.:.|.
Human   417 DAENESMAKIAELEKQ---LSQARKELETLRERFSES-TAMGPSRRPPEPEKAPPAAPTRPSALE 477

  Fly   564 TKNMELQT--LSRSL--PRSASS-----------GDGSLANGGLMAGSTS-----------GAAS 602
            .|..||:.  |.|.|  |..|.|           ..|.....|:..||.|           |||
Human   478 LKVEELEEKGLIRILRGPGDAVSIEILPVAVATPSGGDAPTPGVPTGSPSPDLAPAAEPAPGAA- 541

  Fly   603 LTLPPPPPPMP-------ASPTASSAAPP----PPPPPAPPAP---PPPPGFSPLGSPSGSLAST 653
               ||||||:|       |.|:|...|||    |.||||||.|   ||||  .|...|.|:....
Human   542 ---PPPPPPLPGLPSPQEAPPSAPPQAPPLPGSPEPPPAPPLPGDLPPPP--PPPPPPPGTDGPV 601

  Fly   654 APSPPHAPPMLSSFQPPPPPVAGFMPAPDG----------AMTIKRKVPTKYKLPTLNWIALKPN 708
            .|.||          |||||..|   .||.          .:..|:.:.||:::|.|||:||||:
Human   602 PPPPP----------PPPPPPGG---PPDALGRRDSELGPGVKAKKPIQTKFRMPLLNWVALKPS 653

  Fly   709 QVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVD-GSLQSSKRFKRPDNVSLL 772
            |:.||:|.||:|||:.:::|.::|||:||        ..|.|..:| .:|:|....|.|...:|:
Human   654 QITGTVFTELNDEKVLQELDMSDFEEQFK--------TKSQGPSLDLSALKSKAAQKAPSKATLI 710

  Fly   773 EHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQ 837
            |..|.:|:||:.||..:..:.:..||.:.||:.|.|:.:|||.:.:||:.|......:..|::..
Human   711 EANRAKNLAITLRKGNLGAERICQAIEAYDLQALGLDFLELLMRFLPTEYERSLITRFEREQRPM 775

  Fly   838 QLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEI 902
            :.|:|||:|||..||:.|:..::..:.::|||.|:..|:.||:.:|..||.|:|.|.|.:.:|||
Human   776 EELSEEDRFMLCFSRIPRLPERMTTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEI 840

  Fly   903 VLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTD 967
            |||||||:||:|||.||||:|||||.|::.||||::.:||||:|..|..|:|:|..|.|:|:..|
Human   841 VLAFGNYMNSSKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLD 905

  Fly   968 KAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHILRDFLNNSEDKLKKIKSDLRHAQEAF 1032
            ||.||:|::|:|||:.|::|::|.::|.   |:.....:|::||..:...:.|:.:|.:.|||||
Human   906 KAGSVSLDSVLADVRSLQRGLELTQREF---VRQDDCMVLKEFLRANSPTMDKLLADSKTAQEAF 967

  Fly  1033 KECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQ---RLRLEKAAALAASKKENDQVLMR 1094
            :..|||||::.:......||:|..||.:|:|:.:||.||   ....::|.|....|.|.......
Human   968 ESVVEYFGENPKTTSPGLFFSLFSRFIKAYKKAEQEVEQWKKEAAAQEAGADTPGKGEPPAPKSP 1032

  Fly  1095 NKVNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKSEPYRRAD 1159
            .|..:.:..|            |:|||.:    ::|:.|..:...:||:|||:..|:::||.|||
Human  1033 PKARRPQMDL------------ISELKRR----QQKEPLIYESDRDGAIEDIITDLRNQPYIRAD 1081

  Fly  1160 AVRRSQRRR 1168
            ..|||.|||
Human  1082 TGRRSARRR 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	120/308 (39%)
		Drf_FH3	374..567	CDD:461885	110/201 (55%)
		FH2	687..1063	CDD:396655	155/376 (41%)
FMNL1	NP_001398057.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		4/11 (36%)
		Drf_GBD	34..281	CDD:461886	117/302 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	167..200		9/72 (13%)
		Drf_FH3	284..>433	CDD:461885	98/152 (64%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	446..474		6/28 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	510..635		48/143 (34%)
		FH2	633..998	CDD:396655	155/375 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1008..1037		5/28 (18%)