Protein Alignment Frl and fhdc1

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: XP_002933539.2
• Gene: fhdc1 / 734113
• XenbaseID: XB-GENE-983433
• Length: 1117
• Species: Xenopus tropicalis
• Alignment Length: 681
• Identity: 175/681 - (25%)
• Similarity: 273/681 - (40%)
• Gaps: 160/681 - (23%)

  Fly   575 SLPRSASSGDGSLANGGLMAGSTSGAASLTLPPPPPPMPASPTASSAAPPPPPPPAPPAP----P 635
            ||.....:||.::....||         :..||||||.|        .|||||||.||.|    |
 Frog     8 SLVNDKENGDCNVVITELM---------VEQPPPPPPQP--------PPPPPPPPPPPLPFQNVP 55

  Fly   636 PPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPDG---AMTIKRKVPTKYKL 697
            |||   ||              |.|        |||||    :|...|   ....||.     ::
 Frog    56 PPP---PL--------------PGA--------PPPPP----LPHQVGNGHGNNSKRN-----RM 86

  Fly   698 PTLNWIALKPNQVRG--TIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNG-TEVDGSLQS 759
            .:..|..:...||||  .|:.....::.: |||....||.|     |......:| .:..|:|:|
 Frog    87 RSFFWKTIPEEQVRGKNNIWTMAAKQQQY-QIDTKTIEELF-----GQKEEPRSGLIKAKGNLKS 145

  Fly   760 SKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEV 824
            |.| :..:.||||:..|..||.|..::.....:::|..|..........|.::.|.|:.|...|:
 Frog   146 SFR-EAKEEVSLLDSKRSMNIGIFLKQFKKSTEEIIGDIREGRCDLYGPEPLQELLKLSPESEEI 209

  Fly   825 KSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTS 889
            |..|.:   ..:...|:..|.||..|.:|...|.::..|.....|......:...:..|..|:..
 Frog   210 KKLKAF---SGEVAKLSLADTFMYLLIQVPNYSLRIEAMVLRKEFGSCHSALKNDMTVIRVATKE 271

  Fly   890 LKQSRKFKAVLEIVLAFGNYLNS-NKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKF 953
            |....:..::|.:||..||.:|: ...|.|.||||.||..|.|||:.....:|||::....:.|.
 Frog   272 LMSCEQLHSILFLVLQAGNIMNAGGYAGNAVGFKLSSLLRLADTKANKPGMNLLHFVALEAQKKD 336

  Fly   954 PELLNFESELYGTDKAASVALENVVADVQELE---KGM-DLVRKEAELRVKGAQTHILRDFLNNS 1014
            ..||.|..:|....:||.::::|:.|:.:.|.   |.: |.::||.||..:      :.|||.::
 Frog   337 VSLLTFSEKLPSVGEAARLSIDNMEAEFKSLSTKTKSIKDQIKKEPELYKQ------MEDFLKDA 395

  Fly  1015 EDKLKKIKSDLRHAQEAFKEC---VEYFGDSSRNADAAAFFALI----VRFTRAFKQHDQENEQR 1072
            ...||.::| ||  .|..|||   :::|.:..........|.:.    .:|.:|.|::.:...|.
 Frog   396 VKDLKDLES-LR--AEIKKECHTLIDFFCEDKETMKLDECFQIFRDFCDKFNKAVKENREREIQD 457

  Fly  1073 LRLEKA----------------AALAASKKEND-QVLMRNKVNQKKQQLPSN----------GAL 1110
            ||.:|.                |....|..||| ::|.:..:....||.|.:          ..|
 Frog   458 LRKQKKLNELEQKRRSWVASENANFGRSSSENDVEILTKAGLEDFLQQRPQSSLNRNSSTRRSRL 522

  Fly  1111 SLQEAVINEL--------------------KSKAHSVR------EKKLLQQDEVYNGALEDILLG 1149
            ||..|...||                    :|..|..|      :.| :::|...|      :|.
 Frog   523 SLGVAADRELQMYLGASQVEETTSKFNSLPRSHTHKPRPTVAWIDSK-VEKDHSLN------ILH 580

  Fly  1150 LKSEPYRRADAVRRSQRRRIDNNRLSRTLEE 1180
            ||:|        .|..:::|.::.:..:||:
 Frog   581 LKNE--------TRDTQQQISSSLVITSLED 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886
		Drf_FH3	374..567	CDD:461885
		FH2	687..1063	CDD:396655	103/390 (26%)
fhdc1	XP_002933539.2	FH2	82..444	CDD:396655	101/385 (26%)
		ActA	914..>1097	CDD:282861