Protein Alignment Frl and diaph1

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: XP_031754640.1
• Gene: diaph1 / 733754
• XenbaseID: XB-GENE-5995330
• Length: 1278
• Species: Xenopus tropicalis
• Alignment Length: 1362
• Identity: 303/1362 - (22%)
• Similarity: 518/1362 - (38%)
• Gaps: 466/1362 - (34%)

  Fly    68 PSLRSR-----SQQPMPTTDELD-----RRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEM 122
            ||.|:.     :..|:.|..||:     :.|.|:|..|:|.|:|.:.||    ||  |::..:||
 Frog    68 PSHRNSTNFPDNSNPLQTLQELEDDVVLQLFEKMLDDMNLNPEKQQPLR----EK--DIMIKREM 126

  Fly   123 VQAKDPPSHYLSKLRTYLDPK-ASRSHRLYLFYFLCQKRKM-VGESTSTQVLRDLEISLRTNHIE 185
            |      |.||...:..:..| :|||..:|:     |..|. :|:::....|..|.:||..|.:.
 Frog   127 V------SQYLHTSKAGMSKKESSRSALMYI-----QDLKSGLGDNSLLLCLESLRVSLNNNPVS 180

  Fly   186 WVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSP 250
            ||:.|   ..:||..|::.|          :|:|      :|:.:|.
 Frog   181 WVQNF---GAEGLSCLLEIL----------KRIQ------DEQASLR------------------ 208

  Fly   251 GGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATD 315
                                  |.|.:|.:
 Frog   209 ----------------------DVRSEHEI----------------------------------- 216

  Fly   316 DIHVSIMCLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKAL-VLELLAAICLV---KGGH 376
                 |.||:|.|||.:|...::...:.|..:|.: :.:|:....: .|:||:|:|::   :..|
 Frog   217 -----IRCLKAFMNNNFGIKAMLGTEDGILLLARA-VDRSVPAMMIDSLKLLSALCILPQPEDMH 275

  Fly   377 EIILGSFDNFKDVCQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEF 441
            |.:|.:.....:: :|..||:.|:: .:|. |..:...|:|||.:|.|:...|:::||||::.|.
 Frog   276 ERVLEALTERAEM-EEMERFKPLLD-GLNI-ASPVALKVSCMQLINAVISQGEELDYRVHIRSEL 337

  Fly   442 TALGLDKYLERIRLTESEELKVQISAY---------------------LDNVFDVAALM------ 479
            ...||.|.|:.:|.||:|:||||:..:                     :|:..||..::
 Frog   338 MRSGLAKLLKELRNTENEDLKVQLGIFDEHSELDSDDLRGRLDDIRIEMDDFSDVFQVLLNTVKD 402

  Fly   480 ----------------------------------------------------------------- 479
                                                                             
 Frog   403 SSAEPLFLSILQHLLLIRNDYDARPQYYKLIDEVISQIILQKNGADPDFKCKHVNIEIENLIDHF 467

  Fly   480 ------EDSETKTSALERVQELEDQLEREID-----RNSEFLYKYAELESESLTLKTEREQLAMI 533
                  |.||:|...|.:..:||.....|:.     :.|:|..|..||:.|..:|..|::::...
 Frog   468 IDKKKVETSESKARDLVKKLDLELTARHELQVEMKAKESDFELKITELQGEKESLDAEKQEITAD 532

  Fly   534 RQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRS---LPRSASSGDGSLANGGLMAG 595
            :||:|.||:.:...::...:||:.      ||. |:.::|.|   :|..::||:
 Frog   533 KQKMETELSQLVEQVEKLSKELEA------TKK-EMASISTSAVLIPVPSASGN----------- 579

  Fly   596 STSGAASLTLPPPPPPMPASPTASSAAPP---------PPPPP-------APP------APPPPP 638
                     :||||||.|..|.|:...||         |||||       |||      .|||||
 Frog   580 ---------VPPPPPPPPPLPGATGIPPPPPLPGGSGIPPPPPLPGGSGIAPPLPAGFGIPPPPP 635

  Fly   639 ---GFS-------------------------------PLGS--------PSGS-LASTAPSP--- 657
               ||.                               |.||        |.|| :....|.|
 Frog   636 LPGGFGIPPPPPLPGGSGIPPPPPLPGGSGIPPPPPLPGGSGIPPPPPLPGGSGIPPPPPFPGGP 700

  Fly   658 --PHAPPMLSSF---------------------------QPPPPPVAGFMPAPDG---------- 683
              |..||....|                           .||||...|.:|.|.|
 Frog   701 GIPPPPPFPGGFGIPPPPPPFPGGPGIPPPPPFPGGPGVPPPPPAFGGGVPPPPGLGGWGAPPPL 765

  Fly   684 --AMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEE-----RFKIGIG 741
              .:..|:....:.:|...||..:.|        .||.::..:.|...:.||:     :..:...
 Frog   766 PFGLAPKKNYKPEVQLKRPNWSKITP--------AELSEKSFWTQTKEDRFEKEELFAKITLTFS 822

  Fly   742 GALRNGSNGTEVDGSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKL 806
            ..:::.......||..:.:.:.|:...:.:|:....:|::|......||.:::...|..::.:.|
 Frog   823 SQIKSSKAKKAEDGDDKKAAQKKKTKELKVLDSKTAQNLSIFLGSFRMPYEEIKNVILQVNEEVL 887

  Fly   807 SLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVD 871
            :...|..|.|.:|...:::...|:..|.||   |.|.::|.:.:..|.|:..:|..:.:...|.:
 Frog   888 TESMVSNLIKQLPEPDQLQMLTEFKNEYKD---LAEPEQFGVVMCSVPRLRPRLNAILFKLLFNE 949

  Fly   872 SVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKR-GPAYGFKLQSLDTLIDTKST 935
            .:..|.|.:.|:..|...:::.:.|.::|||.|..||::|:..| ..||||.:..|..|.||||.
 Frog   950 QIENIKPDIVSVTAACEEVQKCQSFASLLEITLLVGNFMNAGSRNADAYGFDISFLCKLKDTKSA 1014

  Fly   936 DKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKE-AELRV 999
            |::::|||::|.|....:|::|.|..|:...:||:.|:.|.       |:|.:|.::|: |:|:
 Frog  1015 DQKTTLLHFLVETCENDYPDVLKFPDEMVHVEKASRVSAET-------LQKNLDQMKKQIADLQ- 1071

  Fly  1000 KGAQTHILRDF-----LNNSEDK-LKKIKSDLRHAQEAF-KECV-------------EYFGDSSR 1044
                    ||.     ..:.:|| ::|:...::.|||.: |.|:             :||....:
 Frog  1072 --------RDIDSFPPTEDEKDKFVEKMTIFVKEAQEQYTKLCMMHENMLSLFQDLGKYFVFDPK 1128

  Fly  1045 NADAAAFFALIVRFTRAFKQHDQENEQRLRLE---KAAALAASKKENDQVLMRNKVNQKKQQLPS 1106
            ......|||.:..|...|....:||::|...|   |.|.||..|.|.:    |.:..|||:||..
 Frog  1129 KTSIEEFFADLQNFRNMFLHALKENQKRREAEEKMKRAKLAKEKAEKE----RLEKQQKKEQLID 1189

  Fly  1107 NGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKS-EPYRRADAVRRSQRR 1167
            ..|                        :.||  .|.::.:|..|.| ..:||....|::.|:
 Frog  1190 MNA------------------------EGDE--TGVMDSLLEALNSGAAFRRKRGPRQANRK 1225

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	64/301 (21%)
		Drf_FH3	374..567	CDD:461885	61/295 (21%)
		FH2	687..1063	CDD:396655	94/402 (23%)
diaph1	XP_031754640.1	Drf_GBD	86..267	CDD:461886	62/297 (21%)
		Drf_FH3	273..463	CDD:461885	36/192 (19%)
		CwlO1	509..>564	CDD:443091	16/61 (26%)
		FH2	771..1146	CDD:396655	94/401 (23%)