Protein Alignment Frl and Fmnl2

DIOPT Version :9

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: XP_006498393.1
• Gene: Fmnl2 / 71409
• MGIID: 1918659
• Length: 1098
• Species: Mus musculus
• Alignment Length: 1155
• Identity: 507/1155 - (43%)
• Similarity: 723/1155 - (62%)
• Gaps: 147/1155 - (12%)

  Fly    77 PMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHYLSKLRTYLD 141
            |||...||:.|||.||.:|:||||||:|||.||:||||::|||||..|.|:||..|:.||:.|||
Mouse    24 PMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLD 88

  Fly   142 PKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLS 206
            |..:|.          :.|:.|.|  ||||||:||||||||||.||:|||::.|:|||.||:|||
Mouse    89 PAVTRK----------KFRRRVQE--STQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLS 141

  Fly   207 FRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGT 271
            |....:..:  .:.|....|..::.:...         |.|:..      |..|::....:.|..
Mouse   142 FAQYAVTFD--FESVESTMESTVDKSKPW---------SRSIED------LHRGSNLPSPVGNSV 189

  Fly   272 LDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNM 336
            ..|.:...:.|        :.|.|....:.||.::|      .||:||.|||||||||.:|||||
Mouse   190 SRSGRHSALRY--------NTLPSRRTLKNSRLVSK------KDDVHVCIMCLRAIMNYQYGFNM 240

  Fly   337 VIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDVCQEKRRFQTLME 401
            |:.|..|:|.|||||.:|:.||||||||||||:|||:|||||||.:|||||:||.||:||:.|||
Mouse   241 VMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLME 305

  Fly   402 YFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQIS 466
            :|.| |..|||||||.|||:|||||||||||:|||||||||.||||:||::::.|||::|:|||.
Mouse   306 HFRN-EDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQ 369

  Fly   467 AYLDNVFDVAALMEDSETKTSALERVQELEDQL----EREIDRNSEFLYKYAELESESLTLKTER 527
            |||||||||.||:||:|||.:|||||:|||:.:    |:..|..:|.:.|..|||.:.:....|.
Mouse   370 AYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKEL 434

  Fly   528 EQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGD-------- 584
            :.:..|.:....::..:::|::..|:.::::.| |..|..||:.......:....||
Mouse   435 DVVREIYKDANTQVHTLRKMVKEKEEAIQRQST-LEKKIHELEKQGTIKIQKKGDGDIAILPVMA 498

  Fly   585 -GSLANGGLMA-----GSTSGAASL--TLPPPPPPMPASPTASSA---------APPPPPPPAPP 632
             |:|:.|..:|     ||..||.:.  ::|||||..|:|.|:.:|         :|||||||.||
Mouse   499 SGTLSTGSELAVGNYVGSVPGATTSGPSVPPPPPLPPSSDTSEAAQNGTASPPMSPPPPPPPPPP 563

  Fly   633 APPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPP--PPVAGFMPAP---------DG--- 683
            .|||||  .||..|:   |.|:|:||..||      |||  ||:.| ..:|         ||
Mouse   564 PPPPPP--PPLPGPA---AETSPAPPLPPP------PPPSAPPLPG-TSSPTVVFNSGLADGPIK 616

  Fly   684 --AMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRN 746
              ::.||:.:.||:::|..||:||||||:.||:|||:|||:|.:.::.:||||.||        .
Mouse   617 LFSVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFK--------T 673

  Fly   747 GSNGTEVDGSLQSSKR---FKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSL 808
            .:.|..:|  |.|||:   .|....|:|||..|.:|:||:.||.|...|::..|||..|||.|.:
Mouse   674 KAQGPAID--LSSSKQKITQKASSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTLPV 736

  Fly   809 ENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSV 873
            :.||.|.:.:||:.|||..:.|..|||..:.|::||:||:|.|::||:..|:.||.::|||.:|:
Mouse   737 DFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLLQKMTIMAFIGNFTESI 801

  Fly   874 HLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKSTDKR 938
            .:::||:.:|..||.|:|.|:|.|.:|||:||.|||:||:|||..|||||||||.|:||||||::
Mouse   802 QMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRK 866

  Fly   939 SSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQ 1003
            .:|||||...::.|:.::..|.:||:..:|||:|:||||:.||:||::||||.::|..:.   ..
Mouse   867 QTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMH---DH 928

  Fly  1004 THILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQE 1068
            ..:|::||.::|.||||::.|.:.||:||.:.|:|||::.:....:.||.:.|||.:|:||.::|
Mouse   929 NTLLKEFLLHNEGKLKKLQEDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAEEE 993

  Fly  1069 NEQRLRLEKAAALAASKKENDQVLMRNKVNQK---KQQ---LPSNGALSLQEAVINELKSKAHSV 1127
            ||.|             |:.:|.||...:.|:   :||   .||:.:...|:.:|.||
Mouse   994 NELR-------------KKQEQALMEKLLEQEALMEQQDAKSPSHKSKRQQQELIAEL------- 1038

  Fly  1128 REKKLLQQDEVY---NGALEDILLGLKSEPYRRADAVRRSQRRRIDNNRL 1174
            |.:::.....||   :||:|||:..|:::|||||||||||.|||.|:..|
Mouse  1039 RRRQVKDNRHVYEGKDGAIEDIITDLRNQPYRRADAVRRSVRRRFDDQNL 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	131/293 (45%)
		Drf_FH3	374..567	CDD:283917	105/196 (54%)
		FH2	687..1063	CDD:280362	170/378 (45%)
Fmnl2	XP_006498393.1	Drf_GBD	23..275	CDD:368864	131/293 (45%)
		Drf_FH3	278..475	CDD:368862	105/198 (53%)
		FH2	622..973	CDD:366959	164/363 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	342	1.000	Domainoid score	I1069
eggNOG	1	0.900	-	-		E1_KOG1923
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H70871
Inparanoid	1	1.050	837	1.000	Inparanoid score	I447
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54599
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		oto94054
orthoMCL	1	0.900	-	-		OOG6_103315
Panther	1	1.100	-	-	O	PTHR45857
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	1	1.000	-	-		X513
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.860