DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Frl and INF2

DIOPT Version :9

Sequence 1:	NP_729954.2	Gene:	Frl / 39561	FlyBaseID:	FBgn0267795	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	NP_071934.3	Gene:	INF2 / 64423	HGNCID:	23791	Length:	1249	Species:	Homo sapiens

Alignment Length:	1133	Identity:	262/1133 - (23%)
Similarity:	437/1133 - (38%)	Gaps:	290/1133 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 EW--VKEFL-----DDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVM 242
            :|  :||.|     |.|...|::....|..||..|.......|:    .:||   .|.|||.:|.
Human    10 KWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGL----RKRL---EGSDGGWMVQ 67

  Fly   243 GNSSSVSPGGGGGLL--SHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHI 305
            ....|     |..||  :....:|.|:|.                   |:|||
Human    68 FLEQS-----GLDLLLEALARLSGRGVAR-------------------ISDAL------------ 96

  Fly   306 AKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAIC 370
              |.:        ..:.|:||:||::.|...::.::..:..::.:|...::..|..|.|||||:|
Human    97 --LQL--------TCVSCVRAVMNSRQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALC 151

  Fly   371 LVK-GGHEIILGSFDNFKDVCQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYR 434
            :.. .||.:.|.:.|::|.||.::.||..:|......:  |:.::|..:..:|.|:...||:..|
Human   152 IYSPEGHVLTLDALDHYKTVCSQQYRFSIVMNELSGSD--NVPYVVTLLSVINAVILGPEDLRAR 214

  Fly   435 VHLQYEFTALGLDKYLERIRLTESEELKVQISAYLD--------------------------NVF 473
            ..|:.||..|.|...|.|:|..|..:|.:|:.|:.:                          ::|
Human   215 TQLRNEFIGLQLLDVLARLRDLEDADLLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLF 279

  Fly   474 DVAALMEDSETKTSALERVQELEDQLEREIDRNSEFLYKYAE-LESESLTLKTEREQLAMIRQKL 537
            ...:....|....|.|:.:..||..|     |:|:.|::..| |.:.::.|.::.::..     |
Human   280 HKVSCSPVSAQLLSVLQGLLHLEPTL-----RSSQLLWEALESLVNRAVLLASDAQECT-----L 334

  Fly   538 EEELTVMQRMLQHNEQELKKRDTLLHTK---NMELQTLSRSLPRSASSGDGSLANGGLMAGSTSG 599
            ||   |::|:|....:.........|..   |:: |:...|.|::.::...|      :.|....
Human   335 EE---VVERLLSVKGRPRPSPLVKAHKSVQANLD-QSQRGSSPQNTTTPKPS------VEGQQPA 389

  Fly   600 AAS-------------------------LTLPPPPPPMPASPTASSAAPPPPPPPAP-------- 631
            ||:                         .:.||||||.|..| .|||.|||||||.|
Human   390 AAAACEPVDHAQSESILKVSQPRALEQQASTPPPPPPPPLLP-GSSAEPPPPPPPPPLPSVGAKA 453

  Fly   632 ----PAPPPPPGFSPLGSPSGSLASTAPS-----PPHAPPMLSSFQPPPPPV----AGFMPAPD- 682
                |.|||.||...:..|:..|....|.     ||..||:.....|||||.    .|:.|.|.
Human   454 LPTAPPPPPLPGLGAMAPPAPPLPPPLPGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPP 518

  Fly   683 -------------GAM------------------TIKRKVPTKYKLPTLNWIALKPNQVR--GTI 714
                         |.|                  :.:|..|...::..|||..|..|..|  .::
Human   519 PPLLPCTCSPPVAGGMEEVIVAQVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSM 583

  Fly   715 FNEL---DDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRFKRPDNVSLLEHTR 776
            :..|   |.|.:  :.||:..|..|..         ......:.::.:.:..|.|..::.|:..:
Human   584 WASLSSPDAEAV--EPDFSSIERLFSF---------PAAKPKEPTMVAPRARKEPKEITFLDAKK 637

  Fly   777 LRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLT 841
            ..|:.|..::.....::|.|.|.:.|..|..:|.::.|.|::|...|:::.:.:..||..   |.
Human   638 SLNLNIFLKQFKCSNEEVAAMIRAGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAK---LA 699

  Fly   842 EEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAF 906
            ..|.|.|.|..:.....::..|.........:.::.|:.|.:..|..||..||:.....:::|..
Human   700 SADHFYLLLLAIPCYQLRIECMLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRI 764

  Fly   907 GNYLN-SNKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAA 970
            ||:|| .:..|.|.|||:.:|..|.:|||...|.:|||:::.......|:||....:|....:||
Human   765 GNFLNYGSHTGDADGFKISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAA 829

  Fly   971 SVALENVVADVQELEKGMDLVRKEAELRVKGAQTHILRDFLNNSEDKL----KKIKSDLRHAQEA 1031
            .:.||              ::|.||...:|                ||    :|:.:.:...||.
Human   830 GINLE--------------IIRSEASSNLK----------------KLLETERKVSASVAEVQEQ 864

  Fly  1032 FKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQ-------ENEQRLRLEKAAA--------- 1080
            :.|.::        |..:||.||...| .|.:|..:       |:.|:|.||...:
Human   865 YTERLQ--------ASISAFRALDELF-EAIEQKQRELADYLCEDAQQLSLEDTFSTMKAFRDLF 920

  Fly  1081 LAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDE-VYNGALE 1144
            |.|.|:..|:.....|..::||||       .:|............||:....|::. |.:..|.
Human   921 LRALKENKDRKEQAAKAERRKQQL-------AEEEARRPRGEDGKPVRKGPGKQEEVCVIDALLA 978

  Fly  1145 DILLGLKSEPYRRADAVRRSQRRRIDNN 1172
            ||         |:...:|::.|.|.|.:
Human   979 DI---------RKGFQLRKTARGRGDTD 997

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	45/194 (23%)
		Drf_FH3	374..567	CDD:283917	49/222 (22%)
		FH2	687..1063	CDD:280362	89/385 (23%)
INF2	NP_071934.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29		6/18 (33%)
		Drf_GBD	<14..152	CDD:283920	44/190 (23%)
		Drf_FH3	156..341	CDD:283917	46/199 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..489		37/149 (25%)
		FH2	554..925	CDD:302999	97/423 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	928..966		9/44 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	988..1076		3/10 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1112..1249
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940