Protein Alignment Frl and Fmnl1

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_001390541.1
• Gene: Fmnl1 / 57778
• MGIID: 1888994
• Length: 1113
• Species: Mus musculus
• Alignment Length: 1164
• Identity: 484/1164 - (41%)
• Similarity: 693/1164 - (59%)
• Gaps: 145/1164 - (12%)

  Fly    66 RQPSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPS 130
            :||::   .:||||...||:.||.:||..|:|||||.:||..||:||||::|||||..|.|:||:
Mouse    20 KQPAV---PKQPMPAAGELEERFTRVLNCMNLPPDKVQLLSQYDNEKKWELICDQERFQVKNPPA 81

  Fly   131 HYLSKLRTYLDP-KASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDT 194
            .|:.||::|||. ..||.........|..||::   ..||||||:||.|||||||.||:|||::.
Mouse    82 AYIQKLKSYLDTGGVSRKVASDWMSNLGFKRRV---QESTQVLRELETSLRTNHIGWVQEFLNEE 143

  Fly   195 NQGLDALVDYLSFRLQMMRHE-QRLQGVLCASEERLNLTNGGDGGEIVMGNSSSV--------SP 250
            |:|||.|::||:|....:.:: :....|...:|:...|....:  ::.....|||        .|
Mouse   144 NRGLDVLLEYLAFAQCSVAYDMESTDSVASGAEKSKPLDQSVE--DLSKAPPSSVPKSRLTIKCP 206

  Fly   251 GGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATD 315
            .....:..|   .|.|...|...:..:..:                   |.||.:::      .|
Mouse   207 PSPRYVHRH---LGAGACWGLTPAHSRKAL-------------------RNSRIVSQ------KD 243

  Fly   316 DIHVSIMCLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIIL 380
            |:||.|||||||||.:.||::|:.|...:|.|||||.:||.||||||||||||:|||:|||:|||
Mouse   244 DVHVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKSPRTKALVLELLAAVCLVRGGHDIIL 308

  Fly   381 GSFDNFKDVCQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALG 445
            .:|||||:||.|:.||:.|||||.: |..|||||||||||:||||||||:||:||.||||||.||
Mouse   309 AAFDNFKEVCGEQHRFEKLMEYFRH-EDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLG 372

  Fly   446 LDKYLERIRLTESEELKVQISAYLDNVFDVAALMEDSETKTSALERVQELEDQL----EREIDRN 506
            ||.||||:|||||::|:|||.|||||||||..|:|::|||.:.||.::||::|:    ||..|..
Mouse   373 LDLYLERLRLTESDKLQVQIQAYLDNVFDVGTLLEETETKNAVLEHMEELQEQVATLTERLRDTE 437

  Fly   507 SEFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQT 571
            ::.:.|.||||.:   |...|::|..:|::..|. |.|....:..|.|.....|::....:||:.
Mouse   438 NDSMAKIAELEKQ---LSQARKELETLRERFSES-TPMGTSRRIPEPEKVPVPTVVRPSALELKV 498

  Fly   572 -------LSR------------SLPRSAS--SGDGSLA-----NGGLMAGSTSGAASLTLPPPPP 610
                   |.|            .||.:|:  |||.:.|     :....|.|...|||...|||||
Mouse   499 EELEEKGLIRILRGPGDVVSIEILPGAAATPSGDDAQAPRVSTDSPSTAESIPEAASPPPPPPPP 563

  Fly   611 PMP---------ASPTASSAAPPPP----PPPAPPAP---PPPPGFSPLGSPSGSLASTAPSPPH 659
            |.|         |.|:|...|||.|    ||||||.|   ||||...|||       :..|.||.
Mouse   564 PPPLPNLQSQQEAPPSAPPLAPPLPGCAEPPPAPPLPGDLPPPPPPPPLG-------TDGPVPPP 621

  Fly   660 APPMLSSFQPP--PPPVAGFMPAPDGAMTIKRKVP--TKYKLPTLNWIALKPNQVRGTIFNELDD 720
            .||      ||  ||.:.|.. .||....:|.|.|  ||:::|.|||:||||:|:.||:|.||:|
Mouse   622 PPP------PPGGPPDILGGQ-GPDIGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELND 679

  Fly   721 EKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVD-GSLQSSKRFKRPDNVSLLEHTRLRNIAISR 784
            ||:.:::|.|:|||.||        ..|.|..:| .:|:.....|.|....|:|..|.:|:||:.
Mouse   680 EKVLQELDMNDFEEHFK--------TKSQGPCLDISALKGKASQKAPTKTILIEANRAKNLAITL 736

  Fly   785 RKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQ 849
            ||..:..|.:..||.:.||:.|||:.:|||.:.:|||.|......:..|::..:.|:|||:|||:
Mouse   737 RKGNLGADRICQAIETYDLQTLSLDFLELLTRFLPTDYERSLIARFEKEQRPMEELSEEDRFMLR 801

  Fly   850 LSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNK 914
            .||::|:..::..:.::|||.|:..|:.||:.:|..||.|:|.|.|.:.:||||||||||:||:|
Mouse   802 FSRIQRLPERMNTLTFLGNFPDTAQLLMPQLNAIIAASMSIKSSDKLRQILEIVLAFGNYMNSSK 866

  Fly   915 RGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVA 979
            ||.||||:|||||.|::.||||::.:||||:|..|..|:|:|..|.|:|:..|||.||:|::|:.
Mouse   867 RGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLG 931

  Fly   980 DVQELEKGMDLVRKEAELRVKGAQTHILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSR 1044
            ||:.|::|::|.::|.   |:.....:|::||..:...:.|:.:|.:.||||::..|||||::.:
Mouse   932 DVRSLQRGLELTQREF---VRQDDCLVLKEFLRANSPTMDKLLADSKTAQEAYESVVEYFGENPK 993

  Fly  1045 NADAAAFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGA 1109
            ....:.||:|..|||:|:|:.:||.||   .:|.||...|.:| :....::....::||:.
Mouse   994 TTSPSMFFSLFSRFTKAYKKAEQEVEQ---WKKEAAADTSGRE-EPPTPKSPPKARRQQMD---- 1050

  Fly  1110 LSLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKSEPYRRADAVRRSQRRR 1168
                  :|:|||.|    ::|:.|..:...:||:|||:..|:::||.|||..|||.|||
Mouse  1051 ------LISELKRK----QQKEPLIYESDRDGAIEDIITDLRNQPYIRADTGRRSARRR 1099

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	122/303 (40%)
		Drf_FH3	374..567	CDD:461885	105/196 (54%)
		FH2	687..1063	CDD:396655	159/378 (42%)
Fmnl1	NP_001390541.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..29		3/11 (27%)
		Drf_GBD	28..299	CDD:461886	122/303 (40%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	173..199		5/27 (19%)
		Drf_FH3	302..>451	CDD:461885	95/152 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	526..646		50/133 (38%)
		FH2	647..1012	CDD:396655	158/375 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1021..1113		31/94 (33%)