DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Frl and SHTN1

DIOPT Version :9

Sequence 1:	NP_729954.2	Gene:	Frl / 39561	FlyBaseID:	FBgn0267795	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	NP_001120683.1	Gene:	SHTN1 / 57698	HGNCID:	29319	Length:	631	Species:	Homo sapiens

Alignment Length:	598	Identity:	122/598 - (20%)
Similarity:	213/598 - (35%)	Gaps:	231/598 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   290 ADAL------DSPSLKRRSR-HIAKLNMGAATDDIH-----------------VSIMCLRAIMNN 330
            |:||      ::.:|||.|. ::|||.....|::|:                 ||:.|.:.|...
Human    83 AEALATKLNKENKTLKRISMLYMAKLGPDVITEEINIDDEDSTTDTDGAAETCVSVQCQKQIKEL 147

  Fly   331 KYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDVCQEKRR 395
            :   :.::..:|....:|:.|  ::|::|  ::|::..:..|| ..:.:|.|     :|.::::
Human   148 R---DQIVSVQEEKKILAIEL--ENLKSK--LVEVIEEVNKVK-QEKTVLNS-----EVLEQRK- 198

  Fly   396 FQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEF----TALGLDKYLERIRLT 456
                             .:..|.:...:.|...|:|...:.|:.:.    .:...:.::|:.:|.
Human   199 -----------------VLEKCNRVSMLAVEEYEEMQVNLELEKDLRKKAESFAQEMFIEQNKLK 246

  Fly   457 ESEELKVQIS----AYLDNVFDVAALMED-SETKTSALERVQELEDQLEREIDRNSEFLYK-YAE 515
            ....|.:|.|    ..|..:.:.|.|.:. .|.:....::|:|||:|||      :|.|:| ...
Human   247 RQSHLLLQSSIPDQQLLKALDENAKLTQQLEEERIQHQQKVKELEEQLE------NETLHKEIHN 305

  Fly   516 LESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSA 580
            |:.:...|:.::::|.:..|..||:    .|.|:|:..||:||                     .
Human   306 LKQQLELLEEDKKELELKYQNSEEK----ARNLKHSVDELQKR---------------------V 345

  Fly   581 SSGDGSLANGGLMAGSTSGAASLTLPPPPPPMPASPTASSAAPPPPPPPAPPAPPPPPGFSPLGS 645
            :..:.|:                                    ||||||.||.|||||      :
Human   346 NQSENSV------------------------------------PPPPPPPPPLPPPPP------N 368

  Fly   646 PSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPDGAMTIKRKVPTKYKLPTLNWIALKPNQV 710
            |..||.|......|                     |.|:...|.|             |.:|...
Human   369 PIRSLMSMIRKRSH---------------------PSGSGAKKEK-------------ATQPETT 399

  Fly   711 RGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALR------------NGSNGTE--VD------G 755
                 .|:.|   .|:....|..:|.|.|:  .||            ..|.|.|  ||      |
Human   400 -----EEVTD---LKRQAVEEMMDRIKKGV--HLRPVNQTARPKTKPESSKGCESAVDELKGILG 454

  Fly   756 SLQ---SSKRFKR--PDNVSLLEHTRLRNIAISRRKL-------------------GMPIDDVIA 796
            :|.   ||:..|.  |:|    ..|.|..| :.|||:                   .||:...::
Human   455 TLNKSTSSRSLKSLDPEN----SETELERI-LRRRKVTAEADSSSPTGILATSESKSMPVLGSVS 514

  Fly   797 AIHSLDLKKLSLE 809
            ::....|.|.:||
Human   515 SVTKTALNKKTLE 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	22/104 (21%)
		Drf_FH3	374..567	CDD:283917	40/202 (20%)
		FH2	687..1063	CDD:280362	37/167 (22%)
SHTN1	NP_001120683.1	DUF972	141..>189	CDD:283750	9/55 (16%)
		Tmemb_cc2	<268..350	CDD:287269	26/112 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	343..511		56/279 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	524..566		2/4 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	579..631
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156515
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930