DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Frl and fhdc2

DIOPT Version :9

Sequence 1:	NP_729954.2	Gene:	Frl / 39561	FlyBaseID:	FBgn0267795	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	XP_009306082.1	Gene:	fhdc2 / 569206	ZFINID:	ZDB-GENE-091118-76	Length:	916	Species:	Danio rerio

Alignment Length:	594	Identity:	151/594 - (25%)
Similarity:	252/594 - (42%)	Gaps:	123/594 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   618 ASSAAPPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPD 682
            |:.:.|.||.||.||.|||||                             .|||...:|......
Zfish     2 ATISIPSPPIPPPPPPPPPPP-----------------------------LPPPASASGLTRVDS 37

  Fly   683 GAMTIKRKVPTKYKLPTLNWIALKPNQVRG--TIFNELDDEKIFKQIDFNEFEERFKIGIGGALR 745
            |         .|::|..|||..:...::.|  .:::...||.....||.|..:|.|      ..:
Zfish    38 G---------RKHRLRNLNWERIPKERIEGRNNVWSGSLDEDSELTIDLNSLDELF------GQK 87

  Fly   746 NGSNGTEVDGSLQSSKRFKRP-----DNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKK 805
            .|......:|..:|..|.:.|     |.|:||:..|..|:.|..|:|.:...:::..:.....::
Zfish    88 EGKKPERANGFRRSLLRCRSPQEISMDKVTLLDSKRSMNVGIFLRQLKIAAIEMVEDVRRGAAER 152

  Fly   806 LSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFV 870
            ...|.:..|.|::|.:.|....|::   ..|:.||.|.|.|:|.|..:.....:|.:|.....|
Zfish   153 YGAEKLAELCKLLPDNEEEARVKKF---NGDRSLLAEPDLFILLLVEIPSFRMRLDVMILQQEF- 213

  Fly   871 DSVHLISPQVQSIAGASTSLKQSRK-------FKAVLEIVLAFGNYLNS-NKRGPAYGFKLQSLD 927
                  .|.|.|:..|:..|:::.:       ...:|.:||..|||:|: ...|.|.||::.||.
Zfish   214 ------DPAVTSLCVAARCLREAARELLSCPELHYILRLVLKAGNYMNAGGYAGNAAGFRISSLL 272

  Fly   928 TLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGM-DL- 990
            .|.|||:.....:|||::...:..|..:||.|.|.|.....|:.::.|:||.|...|:..: ||
Zfish   273 KLADTKANKPGMNLLHFVAMEVVKKDKDLLMFSSRLSHVSPASRLSEESVVEDFSRLQSRVADLR 337

  Fly   991 VRKEAELRVKGAQTHILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYF--GDSSRNADAAA--F 1051
            ||.:|:..:: .||   |.||.::|.:||:.:::|...|::.:..||:|  .|.:...:.|.  |
Zfish   338 VRAQADAEIE-QQT---RTFLQDAEVRLKEAQNELESLQQSSEALVEFFCEDDKTFKLEEACHIF 398

  Fly  1052 FALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAV 1116
            .....||.||.    |||.:| .|::...:|   :|.:.|       :|::.|          |:
Zfish   399 HCFCHRFQRAV----QENTER-ELQEQRRVA---RERENV-------EKRRSL----------AL 438

  Fly  1117 INELKSKAHSVREKKLLQQDEVYNGALEDILLGLKSEPYRRADAVRRSQRRRI-------DNN-- 1172
            ...|:::..|...:..||:...|.|:...:        .|.:...:||:.|.:       |:|
Zfish   439 CTGLEAERDSDDLEHALQRSLSYTGSRRSL--------RRLSQYFQRSEERNLKSDSQHPDSNLH 495

  Fly  1173 --RLSRTLE 1179
              |.||..|
Zfish   496 LERSSRDSE 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920
		Drf_FH3	374..567	CDD:283917
		FH2	687..1063	CDD:280362	106/396 (27%)
fhdc2	XP_009306082.1	FH2	40..406	CDD:280362	103/385 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170592132
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.840