Protein Alignment Frl and grid2ipa

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: XP_009297619.1
• Gene: grid2ipa / 561017
• ZFINID: ZDB-GENE-091113-42
• Length: 1804
• Species: Danio rerio
• Alignment Length: 608
• Identity: 154/608 - (25%)
• Similarity: 270/608 - (44%)
• Gaps: 91/608 - (14%)

  Fly   487 SALERVQE-LEDQLEREIDRNSEFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQRMLQH 550
            |.|::.|: |:.||:::  :..:...:....:.:.|....:::||    |:||::..:.|:.:|.
Zfish  1253 SQLQQQQQLLQQQLQQQ--QQQQLQQQQQRQQQQQLQQLEQQQQL----QQLEQQQQLQQQQIQQ 1311

  Fly   551 NEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLM--------AGSTSGAASLTLPP 607
            .:.:.:::        ::.|...||.|:..|......:...:.        ..|...|.|...||
Zfish  1312 QQAQQQQQ--------IQQQQQHRSTPQIPSVAQARQSPQPMYHEHRHHHHHRSHHEAQSQMQPP 1368

  Fly   608 -PPPPMPASPTASSAAPPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPP 671
             .|.|...:||..|:..||||||.||...|||  .|.|||..|.:|      |
Zfish  1369 ISPQPQTHNPTEGSSVEPPPPPPLPPPCVPPP--LPKGSPQKSDSS------H------------ 1413

  Fly   672 PPVAGFMPAPDGAMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERF 736
                         |::||          |.|..::.::  |||:.:::::.     |:::..:..
Zfish  1414 -------------MSVKR----------LRWEQVENSE--GTIWGQMEEDS-----DYDKLSDMV 1448

  Fly   737 KIGIGGALRNGSNGTEV---DGSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAI 798
            |. :...|..|:..|.|   :.|.| .:.||:.|.|.:|.|.:..|.:|....|.:...::...:
Zfish  1449 KY-LDLELHFGTQKTPVALPEPSPQ-VETFKKKDVVEILSHKKAYNASILIAHLKLSPGELRQVL 1511

  Fly   799 HSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIM 863
            .::..::|...:::.|....|.|.||:.|::|   |.|...|:|.|:|:||:..|....::|..:
Zfish  1512 MTMSSERLEPPHIKQLLLYAPDDDEVRQYEQY---RNDPGKLSEPDQFVLQMLSVPEYKTRLKSL 1573

  Fly   864 NYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSN--KRGPAYGFKLQSL 926
            ::.....:....:......:..||..||.|:|...:||.|||.|||||:.  |.|...|||:..|
Zfish  1574 HFKTTLQEKTEEMRGAYDCVFKASLELKNSKKLAKILEFVLAMGNYLNNGQPKTGKTTGFKINFL 1638

  Fly   927 DTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLV 991
            ..|..||:.|.:|:.||.:|.::...|||:|:|..||....:||.|...|:.:|..:|...:..:
Zfish  1639 TELSTTKTVDGKSTFLHILVKSLCQHFPEVLDFGKELVMVPQAAKVNQRNITSDFNDLHATIQDI 1703

  Fly   992 RKEAELRVKGAQTH---ILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFA 1053
            |...:.....|:..   ::..||.||...::.::|..:.|.|.|.:...|||:..:......||.
Zfish  1704 RVACQKMPATAEDRFAVVMSGFLENSHPAVQSLESLQQRAMEEFCKVASYFGEDGKTTTTENFFG 1768

  Fly  1054 L----IVRFTRAFKQHDQENEQR 1072
            :    |.:|.|.......||..|
Zfish  1769 IFAEFIAKFERTLSDIQTENPPR 1791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886
		Drf_FH3	374..567	CDD:461885	14/80 (18%)
		FH2	687..1063	CDD:396655	103/387 (27%)
grid2ipa	XP_009297619.1	PDZ1_L-delphilin-like	49..124	CDD:467225
		PDZ_canonical	131..202	CDD:483948
		HN_L-delphilin-R1_like	230..309	CDD:259820
		PDZ2_L-delphilin-like	385..459	CDD:467226
		HN_L-delphilin-R2_like	498..577	CDD:259821
		FH2	1406..1778	CDD:396655	106/424 (25%)