Protein Alignment Frl and daam1b

DIOPT Version :9

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_001025307.1
• Gene: daam1b / 560060
• ZFINID: ZDB-GENE-030131-4212
• Length: 1079
• Species: Danio rerio
• Alignment Length: 1273
• Identity: 309/1273 - (24%)
• Similarity: 521/1273 - (40%)
• Gaps: 349/1273 - (27%)

  Fly    33 RNGHQHNGSISSGTLQKQD-------LRYDIGCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAK 90
            |.|..|..|......|..|       ||.|....:.     :|:|      |:|:.||||..|::
Zfish     6 RGGGGHGASFFFCCFQSSDHPEITYRLREDFALQTM-----EPAL------PIPSYDELDAMFSE 59

  Fly    91 VLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDP-----PSHYLSKLRTYLDPKASRSHRL 150
            ::..:||.....:.:.....||||.:.|.::..|.::.     |..|:.:|.:    .|:|...|
Zfish    60 LVDELDLTEKHREAMFALPAEKKWQIYCSKKKEQEENKGATSWPEFYIDQLNS----MAARKTLL 120

  Fly   151 YLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHE 215
            .|     :|.:   |....:.:..|:.:|||..:.:|..|:|     ||.|...|:| |:.|.:|
Zfish   121 AL-----EKEE---EEERNKTIESLKTALRTQPMRFVTRFID-----LDGLTCILNF-LKSMDYE 171

  Fly   216 QRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTM 280
                                                                   |.:|:
Zfish   172 -------------------------------------------------------TTESQ----- 176

  Fly   281 SYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIM-CLRAIMNNKYGFNMVIQHREAI 344
                                                ||.|:: |::|:|||..|...|:.|.|:|
Zfish   177 ------------------------------------IHTSLIGCIKALMNNSQGRAHVLSHTESI 205

  Fly   345 NCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDVCQEKRRFQTLM--------E 401
            |.||.||...:::||..|||::.|:|||.|||:.||.:..:::....|:.|||||:        .
Zfish   206 NIIAQSLATDNIKTKVAVLEIMGAVCLVPGGHKKILEAMLHYQKFACERTRFQTLLNDLDKSTGR 270

  Fly   402 YFMNFEAFNIDFMVACMQFMNIVVH---SVEDMNYRVHLQYEFTALGLDKYLERIRLTESEEL-- 461
            |     ...:....|.|.|:|.|:.   ....:.:||||:|||..||:...::::|..|:..|
Zfish   271 Y-----RDEVSLKTAIMSFINAVLSQGAGESSLEFRVHLRYEFLMLGIQPIIDKLRSHENSTLDR 330

  Fly   462 ----------------------------------------------------------------- 461
                                                                             
Zfish   331 HLDYFEMLRNDDELTLSRRFEAIHIDTKSATQVFELVRKKLAHTDAYPHFMSVLHHCLLMPHKRS 395

  Fly   462 --KVQISAYLDNVFDVAALMEDS--ETKTSALE---------------RVQELEDQLEREIDRNS 507
              .||....||.:.....|..|.  :...:.||               .|::.::|.|:....:.
Zfish   396 GNTVQYWLLLDRIVQQMVLQNDKGHDPDATPLENFNVKNVVRMLVNENEVKQWKEQAEKMRKDHH 460

  Fly   508 EFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHN--EQELKKRDTLLHTKNMELQ 570
            |...|..:.|.|......|:|::.....|::|:|.  :.|.:|.  :|::.:..|.||    ||.
Zfish   461 ELQQKMEKKERECDAKTQEKEEMMQTLNKMKEKLE--REMGEHKLVKQQVAEMTTRLH----ELS 519

  Fly   571 TLSRSLPRSASSGDGSLANGGLMAGSTSGAASLTLPPPPPPMPASPTASSAAPPPPPPPA----P 631
            |      |..:|..|.....|.:.|.       .|||||||    |......|||||||.    |
Zfish   520 T------RQIASVPGGPPVSGPLGGP-------LLPPPPPP----PPGGMMPPPPPPPPCGAMMP 567

  Fly   632 PAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPDGAMTIKRKVP-TKY 695
            |.|||||     |.|        |.||..||..|:   ||||     .||.|....|:.:| ...
Zfish   568 PPPPPPP-----GGP--------PPPPGRPPFGSA---PPPP-----GAPIGPSLKKKNIPQPSN 611

  Fly   696 KLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALR--------NGSNGTE 752
            .|.:.||..|..|::.||::.::||.::||.:|..:.|:.|     .|.:        |.:...|
Zfish   612 PLKSFNWAKLSENKLEGTVWADVDDGRVFKILDLEDIEKTF-----SAYQRQQDFFMVNNNKQKE 671

  Fly   753 VDGSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKK-LSLENVELLQK 816
            .:....|||:.|   .:|:::..|.:|..|...:|.:..:::..||.::|.:: |..:.:|.:.|
Zfish   672 TEDDTLSSKKVK---ELSVIDGRRAQNCNILLSRLKLSNEEIKRAILTMDEQEDLPKDMLEQMLK 733

  Fly   817 MVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQ 881
            .||..::|...:|:   :.:...:.:.|:|:.::||:.....:|..:.:...|.:.:..|.|:|:
Zfish   734 FVPEKSDVDLLEEH---KHELDRMAKADRFLYEMSRINHYQQRLQSLYFKKKFAERIAEIKPKVE 795

  Fly   882 SIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKST-DKRSSLLHYI 945
            ::..||..:..||.||.:||:|||||||:|..:||.|||||:.||:.:.||||: ||..:||||:
Zfish   796 ALTKASKEVLHSRNFKQLLEVVLAFGNYMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYL 860

  Fly   946 VATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTH----- 1005
            :..:..|:.:::.|:.||....:||.|.:..:..::..|..|:..|..|.:.:.|..|.:
Zfish   861 ITILEKKYSKVMLFQEELKNVPEAAKVNMTELEKEINNLRSGLKSVESELDFQKKRPQEYGDKFV 925

  Fly  1006 -ILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQEN 1069
             ::..|:..:......::..|..|:|.|.:.|::||:.:.......||.:..:|.::|.:..|||
Zfish   926 SVVSQFITVASFSFSDVEDSLCEAKELFIKTVKHFGEDADKMQPDEFFGIFDQFLQSFAEARQEN 990

  Fly  1070 EQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQ 1134
            |...|          :||.::...|                  .||.:.|.:.|....|:.|...
Zfish   991 ENIRR----------RKEEEERRAR------------------MEAQLKEQREKERKARKAKENG 1027

  Fly  1135 QDEVYNGALEDILLGLKS-EPYRRADAVRRSQRRRIDN 1171
            :|:  .|..:|::..|:| |.:.:..:..:..|:||::
Zfish  1028 EDD--GGEFDDLVSALRSGEVFDKDLSKMKRNRKRINS 1063

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	65/299 (22%)
		Drf_FH3	374..567	CDD:283917	55/291 (19%)
		FH2	687..1063	CDD:280362	106/392 (27%)
daam1b	NP_001025307.1	Drf_GBD	45..232	CDD:283920	66/306 (22%)
		Drf_FH3	235..439	CDD:283917	37/208 (18%)
		FH2	603..983	CDD:280362	106/390 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54599
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.950