DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Frl and grid2ipb

DIOPT Version :9

Sequence 1:	NP_729954.2	Gene:	Frl / 39561	FlyBaseID:	FBgn0267795	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	XP_009304908.1	Gene:	grid2ipb / 559717	ZFINID:	ZDB-GENE-040724-161	Length:	1383	Species:	Danio rerio

Alignment Length:	1386	Identity:	284/1386 - (20%)
Similarity:	469/1386 - (33%)	Gaps:	439/1386 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PHSHAHHHSMRNG------------HQHNGSISSGTLQKQDLRYDIGCSSQYQHVRQPSLRSRSQ 75
            |.|.|....:|.|            |....:......|.:.||..:.|....|.....||....:
Zfish   110 PCSPAGRSGLRAGDYVMEVNGIPVKHHEMAAALIKASQGRTLRLGVLCMGSRQKRSSGSLEGLQK 174

  Fly    76 QPMPTTD-----------ELDRRFAKVLASMDLPPDKAKL---LRNYDDEKK--W------DMIC 118
            .    ||           |.:||..::|.:.  |..|.||   |:.:..|:|  |      |::.
Zfish   175 D----TDGMRQDRKHKALEFNRRVEEILRNE--PEVKEKLFAVLKQFAAERKVDWLASVLPDILT 233

  Fly   119 DQEMVQAKDPPSHYLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNH 183
            .:|..|       .:|.:|.:: ||..|.          :..:.|.:|...::.|...:....|.
Zfish   234 TEEQQQ-------LISNIRIFI-PKKHRQ----------RFDEAVSQSLINRMCRSKSLGEPQNR 280

  Fly   184 IEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCAS-------------EERLNLTNGG 235
            :.                      |.:...|.:|.||...||             :..|..:|..
Zfish   281 LR----------------------RSRSQDHHERPQGSKRASSVPRDTGDEPAQNDRTLRKSNTM 323

  Fly   236 DGGEIVMGNS-------------------------SSVSPGGGGGLLSHGNSTGHGL--ANGTLD 273
            ...:.|.|.:                         .||.||....  :.|..||..:  .|| ||
Zfish   324 IPTQYVSGVNQRTIRVYRGKKSFGFTLRGHAPVWIDSVMPGSPAE--ACGLKTGDRILFLNG-LD 385

  Fly   274 SRQ-QHTMSYGFLR-----PTI-------------ADALDSPSLKRRSRHIAKLNMGAATDDIHV 319
            .|. .|......|:     |::             ::..::||.. |||..|..::....:.:..
Zfish   386 MRNCSHEKVVSMLQGSGAMPSLVVEEGPVDYPQSDSEPEETPSAP-RSRSPALSSLQWVAEILPP 449

  Fly   320 SIMCLRAIMNNKYGFNMVIQHREAINCIALSLI--HKSLRTKAL----VLELLAAICLVKGGHEI 378
            ||.......:.:....:.:|.|..| |.||...  |:::.|..:    ||:..|...:.:..:::
Zfish   450 SIRVHGRTFSQQLEHLLTLQERYTI-CKALETFFQHRNVDTLIVDVFPVLDTPAKQLIWQFIYQL 513

  Fly   379 ILGSFDNFKDVCQEKRRFQTLMEYFMNFEAF-----------NIDFMVACMQFMNIV-VHSVEDM 431
            :         ..:|:...:|.:..|:.|::.           :....|:.....|.| ..|.:|.
Zfish   514 L---------TYEEQEHCKTKIARFLGFKSAEPEVGAETHRRSSSMRVSGTSHKNTVRERSSDDC 569

  Fly   432 NYRVHLQYEFTALGLDKYLERI-----------RLTESEELKVQISAY--LDNVFDV-------- 475
            ....|       ||:..:.:.:           ...||.:|......|  |.||:.|
Zfish   570 IIGTH-------LGMGTFTDPVTPEERQCGDGTSFPESPDLSHMTGVYTELGNVYPVKSSQSLQS 627

  Fly   476 -----AALMEDSETKT--------SALERVQELE---------DQLER---------EIDRNSEF 509
                 ||.|..:|:.|        :|..|...|.         .|.|.         .:|.|
Zfish   628 HSSPRAAGMGLAESNTYTQSFTHSTAGNRKSGLSLTWTDSFPGPQFETYQQTVASPDSVDSN--- 689

  Fly   510 LYKYAELE--------SESLTLKTEREQLAMI-----RQKLEEELTVMQRMLQH----------- 550
              .|..|:        |:.|:...:|.:|...     .:..::.|..:...|.|
Zfish   690 --PYVSLDSPPASPLPSDELSPLPQRRKLFTFSRPPRSRDTDKFLDALSEQLGHRVNIVDDFKGG 752

  Fly   551 --NEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSGAASL-----TLPPP 608
              :.:|:..:|      ..|:..|...| .||||.|.|.::.......:||:..:     :.|||
Zfish   753 ENDYEEMSFQD------EQEVNMLPHEL-SSASSEDHSSSDDSTSVSYSSGSDHIPPPPQSPPPP 810

  Fly   609 PPP----------------MPASPTASSAAP---PPPPPPAP----------------------- 631
            |||                :|..|.|....|   ||||||.|
Zfish   811 PPPLQFTDSPSPLPITPEHLPQPPPAFQHHPIIAPPPPPPRPFLANRPSLHKVLPTREELRAQHS 875

  Fly   632 ------PAP------------------------PPPPGFS---------------------PLGS 645
                  |.|                        |.||..|                     |..|
Zfish   876 HPRRSSPQPSSQPILQLHQPKAHPILQSSPHTSPQPPHTSAQHTRLQHPSQSIYQSQQTTVPRTS 940

  Fly   646 PS-----------------GSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPDGA----MTIKR 689
            ||                 |:|:|..|.|| .||:.....|||.|    .|:|..:    |::||
Zfish   941 PSLTKQKSLHSQPSQQSFEGTLSSKVPPPP-PPPLPPPCDPPPLP----KPSPKASDNNHMSVKR 1000

  Fly   690 KVPTKYKLPTLNWIALKPNQVRGTIFNELDDE----KIFKQIDFNEFEERFKIGIGGALRNGSNG 750
                      |.|..::.::  |||:.:|.|:    |:...:.:.:.:..|     |..||..:.
Zfish  1001 ----------LRWEQVENSE--GTIWGQLGDDPDYHKLSDMVKYLDLDLYF-----GTQRNSISL 1048

  Fly   751 TEVDGSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQ 815
            .|   .....:..|:.|.|.:|.|.:..|.:|....|.:...::...:.::..::|...:::.|.
Zfish  1049 PE---PTFLPENLKKKDVVEILSHKKAYNASILIAHLKLAPKELRDILMTMSTERLEPAHIKQLL 1110

  Fly   816 KMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQV 880
            ...|.|.|||.::.|   .:|...|:|.|:|:||:..|....::|..:.:.....:....:....
Zfish  1111 LYAPDDEEVKQFQHY---DQDPAKLSEPDQFVLQMLLVPEYKTRLRSLLFKTTVQEKTEEMRAAY 1172

  Fly   881 QSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSN--KRGPAYGFKLQSLDTLIDTKSTDKRSSLLH 943
            :.|..||..||.|::...:||.|||.|||||:.  |.....|||:..|..|..||:.|.:|:.||
Zfish  1173 ECIYKASLELKNSKRLAKILEFVLAMGNYLNNGQPKTNKTTGFKINFLTELNTTKTVDGKSTFLH 1237

  Fly   944 YIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVR-------KEAELRVKG 1001
            .:..::...|||||.|..:|.....||.|....:.||:.::...:..:|       ..||.|...
Zfish  1238 ILAKSLCQHFPELLGFSRDLITVPLAAKVNQRTITADLSDVHSTIQDIRTACVKIPATAEDRFAA 1302

  Fly  1002 AQTHILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQ-- 1064
                ::..||.|....::.:.|..:.|.:.|.:...|||:.|:......||.:...|...|::
Zfish  1303 ----VMSSFLENCHPAVQSLDSLQQRAMDEFHKVASYFGEDSKVTTTETFFGIFAEFISKFERAL 1363

  Fly  1065 ---HDQENEQRLRLEKAAALA 1082
               ...||.:..|:  |:.||
Zfish  1364 SETQGTENPKSPRI--ASPLA 1382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	71/380 (19%)
		Drf_FH3	374..567	CDD:283917	43/282 (15%)
		FH2	687..1063	CDD:280362	97/388 (25%)
grid2ipb	XP_009304908.1	PDZ_signaling	9..69	CDD:238492
		PDZ_signaling	80..156	CDD:238492	9/45 (20%)
		HN_L-delphilin-R1_like	183..262	CDD:259820	21/98 (21%)
		PDZ_signaling	335..410	CDD:238492	15/77 (19%)
		HN_L-delphilin-R2_like	451..530	CDD:259821	14/88 (16%)
		FH2	995..1360	CDD:280362	98/391 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940