Protein Alignment Frl and Diaph2

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: XP_006528644.1
• Gene: Diaph2 / 54004
• MGIID: 1858500
• Length: 1109
• Species: Mus musculus
• Alignment Length: 1185
• Identity: 283/1185 - (23%)
• Similarity: 472/1185 - (39%)
• Gaps: 304/1185 - (25%)

  Fly    88 FAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKD-PPSHYLSKLRTYLDPKASRSHRLY 151
            |.|::..|:|..:|...||..|...|.:|:.......:|. ..|..|..|:       :..|...
Mouse   113 FEKMMEDMNLNEEKKAPLRKKDFSIKREMVVQYISATSKSIVGSKVLGGLK-------NSKHEFT 170

  Fly   152 LF--YFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRH 214
            |.  .::.:.|..:.:......|..|.:||.::.:.||..|   ..:||..|:|.|
Mouse   171 LSSQEYVHELRSGISDEKLLNCLESLRVSLTSHPVSWVNNF---GYEGLGVLLDVL--------- 223

  Fly   215 EQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHT 279
                        |:|                                          ||.:||
Mouse   224 ------------EKL------------------------------------------LDKKQQ-- 232

  Fly   280 MSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVIQHREAI 344
                                   .:|.|.|.       :..|.||:|.||||:|...::....::
Mouse   233 -----------------------ENIDKKNQ-------YKVIQCLKAFMNNKFGLQRILGDERSL 267

  Fly   345 NCIALSLIHKSLRTKALVLELLAAICLVKGGHEII----LGSFDNFKDVCQEKRRFQTLMEYFMN 405
            ..:|.::..|.......::::|:|||:|  |.|.|    ||......:: ..:.||..::|...|
Mouse   268 LLLARAIDPKQQNMMTEIVKILSAICIV--GEENILDKLLGGITAAAEL-NNRERFSPIVEGLEN 329

  Fly   406 FEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQISAYLD 470
            .||.::  .||||||:|.:|.|..|:::|:||:.||...||...|..::..|:|.|.:|:..:.:
Mouse   330 NEALHL--QVACMQFINALVTSPYDLDFRIHLRNEFLRCGLKAMLPTLKEIENEGLDIQLRVFEE 392

  Fly   471 N-----------VFDVAALMED---------SETKTSALER------------------------ 491
            |           :.|:.|.|:|         :..|.:|.|.
Mouse   393 NKEDDLSELSHRLNDIRAEMDDINEVYHLLYNMLKDTAAEPYLLSILQHFLLIRNDYYIRPQYYK 457

  Fly   492 -VQELEDQLEREID-RNSEFLYKY----------------AELESESLTLKTEREQLAM-IRQKL 537
             ::|...|:..... .:.:|.|:.                |::|        |.||.|| ..:|.
Mouse   458 IIEECVSQIVLHCSGMDPDFKYRQRIDFDFTHLLDACVNKAKVE--------ENEQKAMEFSKKF 514

  Fly   538 EEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSGAAS 602
            :||.|..|..    :.||:|||..:.....|:|.|......||..|
Mouse   515 DEEFTARQEA----QAELQKRDEKIKELETEIQQLRGQGVPSAIPG------------------- 556

  Fly   603 LTLPPPPPPMPASPTASSAAPPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSF 667
               ||||||:|      .|.|.|||||.||.|||.||..|  .|...|......||..||.||..
Mouse   557 ---PPPPPPLP------GAGPCPPPPPPPPPPPPLPGVVP--PPPPPLPGMPGIPPPPPPPLSGV 610

  Fly   668 QPPPPPVAGFMPAPDGAMTI----KRKVPTKYKLP--TLNWIALKPNQV-RGTIFNELDDEK--- 722
            .|||||..|..|...|.:.:    |:|...|..:|  .:||..::|.:: ...::.:|.:||
Mouse   611 PPPPPPPGGVFPLLSGPIELPYGMKQKKLYKPDIPMKRINWSKIEPKELSENCVWLKLKEEKYEN 675

  Fly   723 --IFKQIDFNEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRFKRPDNVSLLEHTRLRNIAISRR 785
              :|.::... |..:.|         |...||.....:|....|:...:.:|:....:|::|...
Mouse   676 ADLFAKLALT-FPSQMK---------GQRNTEAAEENRSGPPKKKVKELRILDTKTAQNLSIFLG 730

  Fly   786 KLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQL 850
            ...||.:::...|..::.:.||...::.|.|.:|....::...:...|..|   |.|.::|.:.:
Mouse   731 SYRMPYEEIKNIILEVNEEMLSEALIQNLVKYLPDQNALRELAQLKSEYDD---LCEPEQFGVVM 792

  Fly   851 SRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKR 915
            |.|:.:..:|..:.:...|.:.|:.|.|.:.::..|...||:|..||.:||::|..|||:||..|
Mouse   793 STVKMLRPRLTSILFKLTFEEHVNNIKPSIIAVTLACEELKKSESFKRLLELILLVGNYMNSGSR 857

  Fly   916 -GPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVA 979
             ..:.|||:..|..:.||||.|::|:|||::......|:.::|.|..||...:.|..|:.:.:.:
Mouse   858 NAQSLGFKINFLCKIKDTKSADQKSTLLHFLAEICDEKYRDILKFPDELEHVESAGKVSAQILKS 922

  Fly   980 DVQELEKGMDLVRKEAELRVKG---AQTH------ILRDFLNNSEDKLKKIKSDLRHAQEAFKEC 1035
            ::..:|:.:    ...|..:|.   |::|      .:..|..|:.::..|:.:...:..:.::..
Mouse   923 NLVAMEQSI----LHLEKNIKNFPPAESHHDKFVEKMMSFTQNAREQYDKLSTMHSNMLKLYESL 983

  Fly  1036 VEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLE---KAAALAASKKENDQVLMRNKV 1097
            .|||.......:...||..:..|...|.:..:||.:|..:|   :.|.||..|.|.:: |.|.|
Mouse   984 GEYFIFDPNTVNMEEFFGDLNTFRTLFLEALKENHKRKEMEEKSRRAKLAKEKAEQEK-LERQK- 1046

  Fly  1098 NQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKSEPYRRADAVR 1162
              ||:||..          ||:              :.||  .|.::::|..|:|      .|..
Mouse  1047 --KKKQLID----------INK--------------EGDE--TGVMDNLLEALQS------GAAF 1077

  Fly  1163 RSQRRRI----DNNR 1173
            |.:|:||    ||.|
Mouse  1078 RDRRKRIPRNPDNRR 1092

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	52/285 (18%)
		Drf_FH3	374..567	CDD:461885	62/259 (24%)
		FH2	687..1063	CDD:396655	90/397 (23%)
Diaph2	XP_006528644.1	Drf_GBD	102..294	CDD:461886	52/285 (18%)
		Drf_FH3	302..490	CDD:461885	42/190 (22%)
		FH2	636..1010	CDD:396655	89/390 (23%)