Protein Alignment Frl and Fmnl2

DIOPT Version :9

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: XP_038962712.1
• Gene: Fmnl2 / 499797
• RGDID: 1560248
• Length: 1098
• Species: Rattus norvegicus
• Alignment Length: 1157
• Identity: 508/1157 - (43%)
• Similarity: 720/1157 - (62%)
• Gaps: 151/1157 - (13%)

  Fly    77 PMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHYLSKLRTYLD 141
            |||...||:.|||.||.:|:||||||:|||.||:||||::|||||..|.|:||..|:.||:.|||
  Rat    24 PMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLD 88

  Fly   142 PKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLS 206
            |..:|.          :.|:.|.|  ||||||:||||||||||.||:|||::.|:|||.||:|||
  Rat    89 PAVTRK----------KFRRRVQE--STQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLS 141

  Fly   207 FRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGT 271
            |....:..:  .:.|....|..::.:...         |.|:..      |..||:....:.|..
  Rat   142 FAQYAVTFD--FESVESTVESTVDKSKPW---------SRSIED------LHRGNNLPSPVGNSV 189

  Fly   272 LDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNM 336
            ..|.:...:.|        :.|.|....:.||.::|      .||:||.|||||||||.:|||||
  Rat   190 SRSGRHSALRY--------NTLPSRRTLKNSRLVSK------KDDVHVCIMCLRAIMNYQYGFNM 240

  Fly   337 VIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDVCQEKRRFQTLME 401
            |:.|..|:|.|||||.:|:.||||||||||||:|||:|||||||.:|||||:||.||:||:.|||
  Rat   241 VMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLME 305

  Fly   402 YFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQIS 466
            :|.| |..|||||||.|||:|||||||||||:|||||||||.||||:||::::.|||::|:|||.
  Rat   306 HFRN-EDNNIDFMVASMQFINIVVHSVEDMNFRVHLQYEFTKLGLDEYLDKLKHTESDKLQVQIQ 369

  Fly   467 AYLDNVFDVAALMEDSETKTSALERVQELEDQL----EREIDRNSEFLYKYAELESESLTLKTER 527
            |||||||||.||:||:|||.:|||||:|||:.:    |:..|..:|.:.|..|||.:.:....|.
  Rat   370 AYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMSKIVELEKQLMQRNKEL 434

  Fly   528 EQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLA---- 588
            :.:..|.:....::..:::|::..|:.::::.| |..|..||:  .:...:....|||.:|
  Rat   435 DVVREIYKDANTQVHTLRKMVKEKEEAIQRQST-LEKKIHELE--KQGTIKIQKKGDGDIAILPV 496

  Fly   589 ------------NGGLMAGSTSGAASL--TLPPPPPPMPASPTASSA---------APPPPPPPA 630
                        .||...|...||||.  ::|||||..|:|.|..:|         :|||||||.
  Rat   497 VASGTLPMGSDLAGGNYVGPVPGAASSGPSVPPPPPLPPSSDTPEAAQNGPASPPMSPPPPPPPP 561

  Fly   631 PPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPP--PPVAGFMPAP---------DG- 683
            ||.|||||  .||..|:   |.|.|:||..||      |||  ||:.| ..:|         ||
  Rat   562 PPPPPPPP--PPLPGPA---AETVPAPPLPPP------PPPSAPPLPG-TSSPTVVFNSGLADGP 614

  Fly   684 ----AMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGAL 744
                ::.||:.:.||:::|..||:||||||:.||:|||:|||:|.:.::.:||||.||
  Rat   615 IKLFSVKIKKPIKTKFRMPVFNWVALKPNQINGTVFNEIDDERILEDLNVDEFEEIFK------- 672

  Fly   745 RNGSNGTEVDGSLQSSKR---FKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKL 806
             ..:.|..:|  |.|||:   .|....|:|||..|.:|:||:.||.|...|::..|||..|||.|
  Rat   673 -TKAQGPAID--LSSSKQKITQKGSSKVTLLEANRAKNLAITLRKAGKSADEICKAIHVFDLKTL 734

  Fly   807 SLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVD 871
            .::.||.|.:.:||:.|||..:.|..|||..:.|::||:||:|.|::||:..|:.||.::|||.:
  Rat   735 PVDFVECLMRFLPTENEVKVLRLYERERKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFTE 799

  Fly   872 SVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKSTD 936
            |:.:::||:.:|..||.|:|.|:|.|.:|||:||.|||:||:|||..|||||||||.|:||||||
  Rat   800 SIQMLTPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTD 864

  Fly   937 KRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKG 1001
            ::.:|||||...::.|:.::..|.:||:..:|||:|:||||:.||:||::||||.::|..:.
  Rat   865 RKQTLLHYISNVVKEKYQQVTLFYNELHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMH--- 926

  Fly  1002 AQTHILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHD 1066
            ....:|::|:.::|.||||::.|.:.||:||.:.|:|||::.:....:.||.:.|||.:|:||.:
  Rat   927 DHNTLLKEFILHNEGKLKKLQDDAKIAQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKQAE 991

  Fly  1067 QENEQRLRLEKAAALAASKKENDQVLMRNKVNQK---KQQ---LPSNGALSLQEAVINELKSKAH 1125
            :|||.|             |:.:|.||...:.|:   :||   .||:.:...|:.:|.||
  Rat   992 EENELR-------------KKQEQALMEKLLEQEALMEQQDPKSPSHKSKRQQQELIAEL----- 1038

  Fly  1126 SVREKKLLQQDEVY---NGALEDILLGLKSEPYRRADAVRRSQRRRIDNNRL 1174
              |.:::.....||   :||:|||:..|:::|||||||||||.|||.|:..|
  Rat  1039 --RRRQVKDNRHVYEGKDGAIEDIITDLRNQPYRRADAVRRSVRRRFDDQNL 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	132/293 (45%)
		Drf_FH3	374..567	CDD:283917	105/196 (54%)
		FH2	687..1063	CDD:280362	169/378 (45%)
Fmnl2	XP_038962712.1	Drf_GBD	23..275	CDD:399398	132/293 (45%)
		Drf_FH3	278..475	CDD:368862	105/198 (53%)
		FH2	622..973	CDD:396655	163/363 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	343	1.000	Domainoid score	I1033
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H70871
Inparanoid	1	1.050	812	1.000	Inparanoid score	I454
OMA	1	1.010	-	-		QHG54599
OrthoDB	1	1.010	-	-		D149905at33208
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		otm45724
orthoMCL	1	0.900	-	-		OOG6_103315
Panther	1	1.100	-	-	O	PTHR45857
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X513
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.980