Protein Alignment Frl and fmnl1

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_001007523.1
• Gene: fmnl1 / 493573
• XenbaseID: XB-GENE-1003193
• Length: 1167
• Species: Xenopus tropicalis
• Alignment Length: 1272
• Identity: 479/1272 - (37%)
• Similarity: 682/1272 - (53%)
• Gaps: 262/1272 - (20%)

  Fly    39 NGSISSGTLQKQDLR--YDIGCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDK 101
            |.:.|....|.:|.|  ...|...|.|....|     |:.|.|.:.||::||..||.:|:|||||
 Frog     3 NAAGSLDMFQARDTRGQSTSGTPPQKQKEGTP-----SKLPRPNSVELEQRFNVVLNAMNLPPDK 62

  Fly   102 AKLLRNYDDEKKWDMICDQEMVQAKDPPSHYLSKLRTYLDPKA-SRSHRLYLFYFLCQKRKMVGE 165
            .::||.||.:|||:::||||..|.|:||:.|:.|||:|||... ||..          ||::
 Frog    63 IQVLRQYDQDKKWELVCDQERFQVKNPPAAYIQKLRSYLDTGGISRKF----------KRRV--- 114

  Fly   166 STSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLN 230
            ..||||||:||||||||||.||:|||.....||||||:|||:          .|| .|..:
 Frog   115 QESTQVLRELEISLRTNHIGWVEEFLSPEVGGLDALVEYLSY----------AQG-SCPID---- 164

  Fly   231 LTNGGDGG------------EIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYG 283
             |...|.|            |.:..:|||.||                  ..|....:..|..|.
 Frog   165 -TECSDNGTPEKSKSLQRSLEDINKSSSSPSP------------------TNTPSRSRNLTARYN 210

  Fly   284 FLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVIQHREAINCIA 348
                     |.|.|..|.::|   .||   .||:||.|||||||||.:.||:||:.|...:|.|.
 Frog   211 ---------LHSRSTMRNTKH---ANM---KDDVHVCIMCLRAIMNYQSGFSMVMSHSSCVNKIT 260

  Fly   349 LSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDVCQEKRRFQTLMEYFMNFEAFNIDF 413
            |||.:|:.||||||||||||:|||:||||:||.:|:.|.::|.|..||:.|||||.. |..||||
 Frog   261 LSLSNKNPRTKALVLELLAAVCLVRGGHELILSAFNYFMEMCGEGARFEKLMEYFRT-EDSNIDF 324

  Fly   414 MVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQISAYLDNVFDVAAL 478
            |||||||:|||||||::||:||.||||||.||||:|||.::.||||.|:|||.|||||:|||.:|
 Frog   325 MVACMQFINIVVHSVKNMNFRVFLQYEFTLLGLDEYLEILKNTESERLQVQIQAYLDNIFDVNSL 389

  Fly   479 MEDSETKTSALERVQELEDQLEREIDR----NSEFLYKYAELESESLTLKTEREQLAMIRQKLEE 539
            :||::||...||.|::|::.|.|..::    .:|::.:.||||.:   |...|.:::..::||..
 Frog   390 LEDTDTKNEMLEHVEDLQEHLTRVTEKLQLTENEYVRRVAELEKQ---LDQCRREMSSAKEKLVV 451

  Fly   540 EL-TVMQRMLQHNEQELKKRDTL-------LHTKNMELQTLSRSLPRSAS--------------- 581
            :. .|.|.::|..  ||.||..|       ..|:.:...|.:..||.:||
 Frog   452 QAPQVTQNIVQRT--ELVKRSVLWVEPAGDTCTEEISDNTFTSDLPSAASTPPLSPSAIRITLIS 514

  Fly   582 ----SGDGSLANG---------------------------------------GLMAG-------- 595
                |.|...:.|                                       .|.|.
 Frog   515 PSVTSTDALSSRGNSPRSTTPPALLPSLPESSEIFSIPAPSPVPSSEDSSDTALKASKVNPVPSP 579

  Fly   596 -------STSGAASLTL-------PPPPPPMPA-------SPTASSA-APPPPP-------PPAP 631
                   .||.|.||:.       ||||||:|:       .|...|| .|||||       ||.|
 Frog   580 PSIIDQTQTSNAQSLSRTHDESPPPPPPPPLPSIAEIPPPPPLPMSADVPPPPPLPELSGIPPPP 644

  Fly   632 P-------APPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAP--DGAMTI 687
            |       ||||||.   :|:|.      .|.||..||  |.|.|.|||..|..||.  :..::|
 Frog   645 PLPMGEQGAPPPPPS---MGAPG------VPPPPPPPP--SGFGPAPPPPPGGQPAATLNTGVSI 698

  Fly   688 KRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTE 752
            |:.:.||.::..|||:||||.|:.||:|..|:|||:.:::|.::|||.||             |:
 Frog   699 KKPIQTKLRMQVLNWVALKPTQINGTVFTHLNDEKVLQELDMSDFEENFK-------------TK 750

  Fly   753 VDGSLQSSKRFK------RPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENV 811
            ..|..|::...|      :|:.|||:|..|.:|:||:.||.|:..:.:.:||...|::..:::.:
 Frog   751 AQGPSQTTFSMKVKAAQNQPNKVSLIETNRAKNLAITLRKGGLSPEAITSAIQKYDMQAFNMDFL 815

  Fly   812 ELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLI 876
            |||.:.:|||.|.:....|..::|....||.||:||:.|..:.|::.::..|.:|.||.|....:
 Frog   816 ELLARFLPTDWERQQISRYCRDQKPLDDLTAEDRFMVHLCSIPRLAERVNTMTFMANFPDMASRL 880

  Fly   877 SPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKSTDKRSSL 941
            .||:.::..||.|:|.|.|.|.:||:|||||||:||:|||.||||:|||||.|::|||||::.:|
 Frog   881 KPQLDALIAASMSIKSSDKLKGILELVLAFGNYMNSSKRGAAYGFRLQSLDVLLETKSTDRKQTL 945

  Fly   942 LHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHI 1006
            |||::..|..|:..|.||..:|...||||:|:|::|:|||:.|:.||:.|:||.   .|.....|
 Frog   946 LHYMIRVICEKYSHLSNFYCDLNFMDKAATVSLDSVLADVKSLQAGMEQVQKEF---TKQDDCLI 1007

  Fly  1007 LRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQ 1071
            |:||:.::.|.||::.:|.:.||||:...|.|||::::....:.||.:.|||.:|:||.:|:.|
 Frog  1008 LKDFIKSNMDSLKQLSADAKTAQEAYDAAVGYFGENAKTTPPSTFFPIFVRFIKAYKQAEQDLE- 1071

  Fly  1072 RLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINELKSKAHSVRE--KKL-L 1133
                        :.|:.:..:...|.....:|.|       |..|:..|:.:.:.:.|  ||| .
 Frog  1072 ------------TWKKQESAVQEAKPETAGKQAP-------QSPVVKSLRPQVNLMAELNKKLQT 1117

  Fly  1134 QQDEVY--NGALEDILLGLKSEPYRRADAVRRSQRRR 1168
            ::..||  |.|:|||:..|:::||||.|..|||.:::
 Frog  1118 KEPRVYEQNWAIEDIITDLRNQPYRRTDVGRRSGKKQ 1154

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	128/306 (42%)
		Drf_FH3	374..567	CDD:461885	98/204 (48%)
		FH2	687..1063	CDD:396655	153/381 (40%)
fmnl1	NP_001007523.1	Drf_GBD	37..283	CDD:461886	128/307 (42%)
		Drf_FH3	286..>423	CDD:461885	80/137 (58%)
		FH2	698..1064	CDD:396655	153/381 (40%)