Protein Alignment Frl and Inf2

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: XP_038969328.1
• Gene: Inf2 / 362790
• RGDID: 1308350
• Length: 1300
• Species: Rattus norvegicus
• Alignment Length: 1206
• Identity: 262/1206 - (21%)
• Similarity: 451/1206 - (37%)
• Gaps: 330/1206 - (27%)

  Fly   111 EKKWDMICDQEMVQAKDPPSHYLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDL 175
            ::||..:.::...|..||....|..    .:|:        |...|.|...:|..|       .|
  Rat    33 QRKWAALKEKLGPQDSDPTEANLES----AEPE--------LCIRLLQMPSVVNYS-------GL 78

  Fly   176 EISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEI 240
            ...|.::...|:.:||:.:  |||.|::.|:                     ||
  Rat    79 RKRLESSDGSWMVQFLEQS--GLDLLLEALA---------------------RL----------- 109

  Fly   241 VMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHI 305
                                  :|.|:|.                   |||||
  Rat   110 ----------------------SGRGVAR-------------------IADAL------------ 121

  Fly   306 AKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAIC 370
              |.:        ..|.|:||:||::.|...::.::..:..::.:|...::..|..|.|||||:|
  Rat   122 --LQL--------TCISCVRAVMNSQQGIEYILSNQGYVRQLSQALDTSNVMVKKQVFELLAALC 176

  Fly   371 LVK-GGHEIILGSFDNFKDVCQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYR 434
            :.. .||.:.|.:.|::|.||.::.||..:|....:.:  |:.::|..:..:|.::...||:..|
  Rat   177 IYSPEGHALTLDALDHYKMVCSQQYRFSVIMNELSDSD--NVPYVVTLLSVINALILGPEDLRTR 239

  Fly   435 VHLQYEFTALGLDKYLERIRLTESEELKVQISAY----------LDNVFDVAALMEDSETKTSAL 489
            ..|:.||..|.|...|.|:|..|..:|.:|:.|:          |..|.|...:....|..||..
  Rat   240 AQLRSEFIGLQLLDILTRLRDLEDADLLIQLEAFEEAKAEDEEELQRVSDGINMNSHQEVFTSLF 304

  Fly   490 ERVQ------ELEDQLE-----REIDRNSEFLYKYAE----------LESESLTLKTEREQLAMI 533
            .:|.      :|...|:     ....|:.:.|::..|          .::|:.||:...|:|..|
  Rat   305 HKVSCSPASAQLLSVLQGLMHLEPAARSGQLLWEALENLVNRAVLLASDAEACTLEEVVERLLSI 369

  Fly   534 RQK-----LEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLM 593
            :.:     |::....:|..|..| |....::|...|..:|.:   :.:..|.....||:.:..:.
  Rat   370 KGRPRPSPLDKAHKSVQTNLGQN-QGSSSQNTATPTAKVEGR---QPVVASPCQHVGSIQSSSMD 430

  Fly   594 AGSTSGAASL----------TLPPPPPPMPASPTASSAAPPPPPPPAPPAP------PPPPGFSP 642
            |.....|:.|          .|||||||:|.|...|..|||||||..||.|      ||||...|
  Rat   431 AAPQLAASPLPTPPLSSSTPVLPPPPPPLPGSGATSPPAPPPPPPLPPPLPGSGTMSPPPPPPPP 495

  Fly   643 LGSPSGSLASTAPSPPHAPPMLSSFQ--------------------PPPPPVAGFMPAPD----- 682
            |..|...|.:.:|.||..||.|...:                    |||||:.|..|.|.
  Rat   496 LPPPLPGLGAVSPPPPPPPPPLPGSRAVSPPAPPPSLPHSHPLPPPPPPPPLPGMCPVPPPPPLP 560

  Fly   683 -----------------------------------GAMTI---KRKVPTKYKLPTLNW------I 703
                                               |:..:   :|..|...::..|||      :
  Rat   561 TAGQVPPPPPLPGFSVPSVVGGVEEIIVAQVDHSLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNV 625

  Fly   704 ALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRFKRPDN 768
            |.:.|.:..|:.:....|   .:.||:..|:.|...:         ....:.|...::  |.|..
  Rat   626 ARERNSMWATLSSPCTAE---VEPDFSSIEQLFSFPM---------AKPKEPSAAPAR--KEPKE 676

  Fly   769 VSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIE 833
            |:.|:..:..|:.|..::.....::|...|.:.|..|..:|.::.|.|::|...|:::.:.:
  Rat   677 VTFLDSKKSLNLNIFLKQFKCSNEEVTGMIQAGDTSKFDVEVLKQLLKLLPEKHEIENLRAF--- 738

  Fly   834 RKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKA 898
            .:|:..|...|:|.:.|..:.....::..|.........:.::.|:.|.:..|..||..|::...
  Rat   739 TEDRAKLASADQFYILLLDIPCYQLRVECMMLCEGTAIVLDMVRPKAQLVLTACESLLTSQRLPV 803

  Fly   899 VLEIVLAFGNYLN-SNKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESE 962
            ..:::|..||:|| .:..|.|.|||:.:|..|.:|||...|.:|||:::..:....|:||....:
  Rat   804 FCQLILKIGNFLNYGSHTGDADGFKISTLLKLTETKSQQSRVTLLHHVLEEVEKSHPDLLQLSRD 868

  Fly   963 LYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHILRDFLNNSEDKL----KKIKS 1023
            |....:||.:.||              ::..||...:|                ||    :|:.|
  Rat   869 LESPSQAAGIHLE--------------IIHSEASANLK----------------KLLEAERKVSS 903

  Fly  1024 DLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLEK----------- 1077
            .:...|:.:.|.::...::||..|..  |..|.:.......:..|:.|:|.||.
  Rat   904 SIPEVQKQYAERLQASIEASRALDKV--FDAIEQKKLELADYLCEDPQKLSLEDTFSTMKTFRDL 966

  Fly  1078 -AAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDE-VYN 1140
             ..||..:|...:|:.   |..::||||       .:|............||:....|::. |.:
  Rat   967 FTRALKENKDRKEQMA---KAEKRKQQL-------AEEEARRPRDEDGKPVRKGPGKQEEVCVID 1021

  Fly  1141 GALEDILLGLKSEPYRRADAVRRSQRRRIDNNRLSR 1176
            ..|.||         |:...:|::.|.|.|.....|
  Rat  1022 ALLADI---------RKGFQLRKTARGRGDTEASGR 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	48/259 (19%)
		Drf_FH3	374..567	CDD:461885	53/228 (23%)
		FH2	687..1063	CDD:396655	82/389 (21%)
Inf2	XP_038969328.1	Drf_GBD	24..177	CDD:461886	48/259 (19%)
		Drf_FH3	181..366	CDD:461885	44/186 (24%)
		FH2	603..967	CDD:418645	87/412 (21%)
		WH2_INF2	1013..1042	CDD:409204	9/37 (24%)
		PRK07764	<1030..1217	CDD:236090	5/19 (26%)
		actin-binding sequence	1033..1036	CDD:409204	1/2 (50%)