Protein Alignment Frl and dia

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Alignment Length: 1294
• Identity: 294/1294 - (22%)
• Similarity: 481/1294 - (37%)
• Gaps: 389/1294 - (30%)

  Fly    33 RNGHQHNGSISSGTLQ------KQDLRYDIGCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAKV 91
            |......|:||||||.      ..|.....|.....|:::|.|:.           |||.:|.::
  Fly    28 RPSKSKGGTISSGTLAHGGRPVSADNYVVPGVEDFEQYIQQLSVA-----------ELDAKFLEI 81

  Fly    92 LASMDLPPDKAKLLRNYDDEKKWDMI---------CDQEMVQAKDPPSHYLSKLRTYLDPKASRS 147
            :..|::|.||.:.|.....|::..||         .::......:.|..|:.    ||......:
  Fly    82 IEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFEKPIDYVE----YLQNGEHST 142

  Fly   148 HRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMM 212
            |::|                  |.:..|.::|.:|.|.|:|||
  Fly   143 HKVY------------------QCVESLRVALTSNPISWIKEF---------------------- 167

  Fly   213 RHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLD---S 274
                                                   |..|:             ||::   :
  Fly   168 ---------------------------------------GVAGI-------------GTIEKLLA 180

  Fly   275 RQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVI- 338
            |.::..||                       .|:...|        |.||:|||||.:|.|:|:
  Fly   181 RSKNNASY-----------------------EKIEFEA--------IRCLKAIMNNTWGLNVVLN 214

  Fly   339 --QHREAINCIALSLIHKSLRTKALVLELLAAICLV--KGGHEIILGSF-----DNFKDVCQEKR 394
              || ..:..:|.||..:..:|....|:|||:.|:|  :.|:|.:|.:.     .:||    ...
  Fly   215 PDQH-SVVLLLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFK----ASE 274

  Fly   395 RFQTLMEYFMNFEAFNIDFMVAC--MQFMNIVVHSVEDMNYRVHLQYEFTALG----LDKYLERI 453
            ||:.:::.....:..:....:||  :.|:|.:.::..|:|:|:||:.|...:|    ||::.:.:
  Fly   275 RFRPIVDALFASDQQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIV 339

  Fly   454 RLTESEELKVQISAY--------------LDNV----------FDVAA-LMEDSETKTSALERVQ 493
            ..:.:|.|:.....:              .|||          |||.. |:.|:.::...|..:|
  Fly   340 EASNNENLQQHFKIFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQ 404

  Fly   494 EL----ED--------QLEREIDRNSEFLYKYAELESE--------SLTLKTEREQLAMIRQKLE 538
            .|    :|        ||..|......|...|.:...|        ||.|....|:......|..
  Fly   405 HLLYIRDDFYFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRS 469

  Fly   539 EELTVMQRMLQHNEQE-------LKKRDTLLHTKNM------ELQTLSRSLPRSASSGDGSLANG 590
            ||.......|:..:||       |:::..|:....:      :|..::..:|.....|.|:
  Fly   470 EEYEKKIEQLESAKQEAEAKAAHLEEKVKLMEANGVAAPSPNKLPKVNIPMPPPPPGGGGA---- 530

  Fly   591 GLMAGSTSGAASLTLPPPPPPMPASPTASSAAPPPPPPP------APPAPPPPPGFSPLGSPSGS 649
                          .||||||||.  .|....|||||||      .||.||||||   :|.|
  Fly   531 --------------PPPPPPPMPG--RAGGGPPPPPPPPMPGRAGGPPPPPPPPG---MGGP--- 573

  Fly   650 LASTAPSPPHAPPMLSSFQPPPPP--VAGFMPAPDGAMTIKRKVPTKYKLPTLNWIALKPNQVRG 712
                 |.||....|.....|||||  :...:|.....:..|:|...|..:...||.|:.|.::..
  Fly   574 -----PPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWKAIVPAKMSD 633

  Fly   713 TIFNELDDEKIFKQIDF-NEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRFKRPDNVSLLEHTR 776
            ..|.....|....|.|| .|...:|                      |||..|:....::.:.|.
  Fly   634 KAFWVKCQEDKLAQDDFLAELAVKF----------------------SSKPVKKEQKDAVDKPTT 676

  Fly   777 LRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVE--------------LLQKMV---PTDAEV 824
            |....:..|.|.......:|.:....||.||.|.::              :||:::   |....:
  Fly   677 LTKKNVDLRVLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHL 741

  Fly   825 KSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTS 889
            |..:|  |:.|.:.|...| :|...:..::|:|.:|..:|:...:.|.|..|.|.:.:...|...
  Fly   742 KRLQE--IKAKGEPLPPIE-QFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEE 803

  Fly   890 LKQSRKFKAVLEIVLAFGNYLNS-NKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKF 953
            ::.|:||..:||::|..|||:|| :|...|:||::..|..|.:||..|.:.:||||:...:..||
  Fly   804 IRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKF 868

  Fly   954 PELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHILRDFLNN----- 1013
            |:.|||..:|...:||:.|              .||.::| |..::..|..::..|..||
  Fly   869 PDALNFYDDLSHVNKASRV--------------NMDAIQK-AMRQMNSAVKNLETDLQNNKVPQC 918

  Fly  1014 SEDKLKKI----------------KSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAF 1062
            .:||..::                |..|: .::.:|:..||:...........|||.|..|..||
  Fly   919 DDDKFSEVMGKFAEECRQQVDVLGKMQLQ-MEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAF 982

  Fly  1063 KQHDQEN-------EQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINEL 1120
            :....:|       |::.||::|...:|.:::..|        |:|:.:....|...||.|::.|
  Fly   983 QAAHNDNVRVREELEKKRRLQEAREQSAREQQERQ--------QRKKAVVDMDAPQTQEGVMDSL 1039

  Fly  1121 -----KSKAHSVREKKLLQQDEVYNGALEDILLGLKSEPYRRADAVRRSQRRRIDNNRL 1174
                 ...|...|.::..:|...  ||            .|||...|...|.|:.|.:|
  Fly  1040 LEALQTGSAFGQRNRQARRQRPA--GA------------ERRAQLSRSRSRTRVTNGQL 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	57/308 (19%)
		Drf_FH3	374..567	CDD:461885	52/255 (20%)
		FH2	687..1063	CDD:396655	102/415 (25%)
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	59/320 (18%)
		Drf_FH3	253..453	CDD:461885	41/203 (20%)
		FH2	608..983	CDD:396655	102/415 (25%)