DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Frl and capu

DIOPT Version :9

Sequence 1:	NP_729954.2	Gene:	Frl / 39561	FlyBaseID:	FBgn0267795	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	NP_001137784.1	Gene:	capu / 33611	FlyBaseID:	FBgn0000256	Length:	1361	Species:	Drosophila melanogaster

Alignment Length:	1363	Identity:	284/1363 - (20%)
Similarity:	450/1363 - (33%)	Gaps:	422/1363 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 QLQHPHSHAHHHSMRNGHQHNGSISSGTLQKQDLRYDIGCSSQYQHVRQPSLRSRSQQPMPTTDE 83
            |.||.|.|.|.|:....|.|                       |.:.|:....|.|......||.
  Fly   151 QRQHHHHHHHIHNAHESHHH-----------------------YPYDRRSLCTSCSSNDSLFTDP 192

  Fly    84 LDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHYL-SKLRTYLDPKASRS 147
            :|                                   |::.:|    ||| :..:.:.:|||.|.
  Fly   193 VD-----------------------------------ELIISK----HYLNTAAKEHNNPKAKRD 218

  Fly   148 HRLYLF---------------YFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKE-----FLD 192
            ..|...               ....|||....:.....:.|...:|: .|.::.|:|     .|.
  Fly   219 RPLSEISVTSVDTLSPNTAKAVLELQKRCRADKLACLSLTRVTYLSI-ANDLQEVEEPDRASILH 282

  Fly   193 DT------NQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPG 251
            ||      |...::..|.....||:   .::|..||          ..|.|..:..|.....:.|
  Fly   283 DTDLLVAPNSPAESSPDEELMALQL---GKKLAQVL----------GSGAGSPLTPGTMEPCAAG 334

  Fly   252 GGGGLLSHGNSTGHGLANG--------------TLDSRQQHTMSY-------------GFLRPT- 288
                       :|..||||              .|.||....::.             |...|.
  Fly   335 -----------SGSPLANGELFNVSKAKKVELQNLSSRFTAAVTQTPPGVTSSTPNESGVTGPAG 388

  Fly   289 -IADALDSPSLKRRSRHIAKLNM----------GAATDDIH----------------------VS 320
             :.....||||:.:|..|.....          .||::::.                      :|
  Fly   389 PLGATTSSPSLETQSTVIISFKSSQTPVQSQTNSAASENVEDDTAPLPLPPPPPGFGTPTTPLLS 453

  Fly   321 IMCLRAIMNNKYGFNMVIQHREAIN--------C-------IALSLIHKSLRTKALVLELL--AA 368
            ...|:.:.      :..::...|.|        |       :..:....||....|..|:.  ||
  Fly   454 SNVLKKVA------SFTVEKSSAGNNSSNPPNLCPTSDETTLLATPCSSSLTVATLPPEIAVGAA 512

  Fly   369 ICLVKGGHEIILGSF---DNFKDVCQEKRRFQTLMEYFM--------------NFEAFNIDFMVA 416
            ...|.||.....||.   :.......||...|.|:::.:              |.|.||    ..
  Fly   513 AGGVAGGAGSRRGSSYVPEKLSFAAYEKFEGQMLIKWLISTMQSNPKSSSGDANQELFN----TL 573

  Fly   417 CMQFMNIVVH----------------SVEDMNYRVHLQYEFTAL-----GLDKYL--------ER 452
            .:||.|.:.:                |..:|....|.:...|:|     .|||..        ..
  Fly   574 ALQFCNNLKYVGVLKQISNEHLDCGFSPYEMYQWTHTEQPTTSLPLTPGKLDKVAAWPFSSTPSG 638

  Fly   453 IRLTESEEL---------------KVQISAYLDNVFDVAALMEDSETKTSALERVQELEDQLERE 502
            ||..||..|               ....:|..||...:..:::......:.|..|..:.::|...
  Fly   639 IRALESASLASLGAGGVAGSLATIATASTASSDNQKTLQQILKKRLLNCTTLAEVHAVVNELLSS 703

  Fly   503 ID----RNSEFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLH 563
            :|    |.|:......||.:.|                   |.||.:......|..:|.
  Fly   704 VDEPPRRPSKRCVNLTELLNAS-------------------EATVYEYNKTGAEGCVKS------ 743

  Fly   564 TKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSGAASLTLPPPPPPMPASPTASSAAPPPPPP 628
            ..:.|.||.|.....:...|..|.......:....|.....:.||||| |..|..:..|||||||
  Fly   744 FTDAETQTESEDCEGTCKCGQSSTKVSDNESAKEDGEKPHAVAPPPPP-PPPPLHAFVAPPPPPP 807

  Fly   629 PAPPAPPP------PPGFSPLGSPSGSLASTAPSPPHAPPML--SSFQPPPPPVAGF-------- 677
            |.||.|||      ||  .|...|.||  .:||.||...|:.  ....|||||::..
  Fly   808 PPPPPPPPLANYGAPP--PPPPPPPGS--GSAPPPPPPAPIEGGGGIPPPPPPMSASPSKTTISP 868

  Fly   678 MPAPDGA--------MTIKRKV--PTKYKLPTLNWIAL----KPNQVRGTIFNELD--------- 719
            .|.||.|        .|:::..  |.|...| |.|..:    .|.....::.|..|
  Fly   869 APLPDPAEGNWFHRTNTMRKSAVNPPKPMRP-LYWTRIVTSAPPAPRPPSVANSTDSTENSGSSP 932

  Fly   720 DE------------------KIFKQID------FNEFEERFKIGIGGALRNGSNGTEVDGSLQSS 760
            ||                  :|:.:|:      .:||.|.|           |.......|....
  Fly   933 DEPPAANGADAPPTAPPATKEIWTEIEETPLDNIDEFTELF-----------SRQAIAPVSKPKE 986

  Fly   761 KRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVK 825
            .:.||..::.:|:..|.||:.|..|.|.:|..::..||:.:|...:|||.::.:..:..|:.|::
  Fly   987 LKVKRAKSIKVLDPERSRNVGIIWRSLHVPSSEIEHAIYHIDTSVVSLEALQHMSNIQATEDELQ 1051

  Fly   826 SYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSL 890
            ..||   .......|...::|:|.:|.:...|.:::.:.:...|.:||.|:..::::::..|..|
  Fly  1052 RIKE---AAGGDIPLDHPEQFLLDISLISMASERISCIVFQAEFEESVTLLFRKLETVSQLSQQL 1113

  Fly   891 KQSRKFKAVLEIVLAFGNYLN--SNKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVAT----- 948
            .:|...|.|..|:|..|||:|  :.:||.|.||.|..|..|.|.||.:..::|||:||.|
  Fly  1114 IESEDLKLVFSIILTLGNYMNGGNRQRGQADGFNLDILGKLKDVKSKESHTTLLHFIVRTYIAQR 1178

  Fly   949 ---------IRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQ- 1003
                     ||...||..:.|       :||.:..|.|...:.:|.|.. |..|....:|..|.
  Fly  1179 RKEGVHPLEIRLPIPEPADVE-------RAAQMDFEEVQQQIFDLNKKF-LGCKRTTAKVLAASR 1235

  Fly  1004 -------THILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSR-------NADAAAFFAL 1054
                   ...:.:|:..::..:.|:...|...::.|.|.:.::..|.:       ......||..
  Fly  1236 PEIMEPFKSKMEEFVEGADKSMAKLHQSLDECRDLFLETMRFYHFSPKACTLTLAQCTPDQFFEY 1300

  Fly  1055 IVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVI 1117
            ...||..||...::....|..|     ...|.:..|:..|..|:.|.::   :|.:||:|.::
  Fly  1301 WTNFTNDFKDIWKKEITSLLNE-----LMKKSKQAQIESRRNVSTKVEK---SGRISLKERML 1355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	64/398 (16%)
		Drf_FH3	374..567	CDD:283917	45/257 (18%)
		FH2	687..1063	CDD:280362	100/445 (22%)
capu	NP_001137784.1	FH2	888..1315	CDD:214697	102/449 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463909
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm9222
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840