DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Frl and form3

DIOPT Version :9

Sequence 1:	NP_729954.2	Gene:	Frl / 39561	FlyBaseID:	FBgn0267795	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	NP_001097527.1	Gene:	form3 / 3346238	FlyBaseID:	FBgn0053556	Length:	1717	Species:	Drosophila melanogaster

Alignment Length:	972	Identity:	238/972 - (24%)
Similarity:	401/972 - (41%)	Gaps:	180/972 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 MNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVK-GGHEIILGSFDNFKDVCQ 391
            |:::.|.:.::::|:.|..:..:|..::...|..|.|||:|:|... .|:...:.:.:.:|::.:
  Fly     1 MDSRIGLDYIVENRDYIAKLGAALDTQNATVKKQVFELLSALCAYSPDGYARAIETLEFYKNLKK 65

  Fly   392 EKRRFQTLM-EYFMNFEAFN--IDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERI 453
            ::.||:.:: |..::..|.:  :|:..|.:.|:|.|:.|...:..|:.::.||..|.:...|..:
  Fly    66 QRYRFKIVINELELSSAAAHPPLDYQAALLAFINCVIISAATLQERIRIRNEFIGLKVLPLLNNL 130

  Fly   454 RLTES---------------------------------------EELKVQ--------ISAY--- 468
            ||.|:                                       ..|.:|        :|.|
  Fly   131 RLLEAGNVESSASPSPPPSLSSESASSATSPVSGSASTSVTPSPSPLHLQRRLTFCGSLSRYSCA 195

  Fly   469 ----LDNVFDVAALMEDSETKTSALERVQELED----QLEREIDRNSEFLYKYAELESESLTLKT 525
                :.|:..||..:.|...:.......||.::    |....|:.||.....||.|
  Fly   196 ALQLVQNLKKVAQSVGDIIVQLDVFVEQQECDEAQSLQAPDGINLNSHLDVFYAIL--------- 251

  Fly   526 EREQLAMIRQKLEEELTVMQRMLQHNEQE------------LKKRDTLL--HTKNMELQTLSRSL 576
              .|:|...|:: ..|.::|.:|:.:.:|            |..|.|||  |..::.|.....|.
  Fly   252 --RQVADTPQEV-PFLNILQHLLRIDPKEPLSDIIWDTTERLVHRATLLESHEDSVRLLRTPSSQ 313

  Fly   577 PRSASSGDGSLANGGLMAGSTS-GAASLTLPPPPPPMPASPTASSAAPPPPPPP---APPAPPPP 637
            ..:..|..||.|:......|.. |.::.|.|||||| |.:|    |||||||||   |.|.||||
  Fly   314 KFACQSCRGSDASSPTRKPSQPVGVSAKTTPPPPPP-PMAP----AAPPPPPPPINGAAPPPPPP 373

  Fly   638 PGFSPLGSPSGSLASTAPSPPHAPPMLSSFQP-PPPPVAG-------FMPAPDGAMTIKRKVPT- 693
            |..:     .|:|    |.||..|.|..:.:| .|.|:|.       .:|..|        .|.
  Fly   374 PMIN-----GGAL----PPPPPPPSMQMASRPRTPDPLAAEAVATAILLPQQD--------TPAP 421

  Fly   694 KYKLPTLNWIALKPNQVRG-----TIFNELDDEKIFKQIDFNEFEERF-----------KIGIGG 742
            |.|:.|:||..:..|:|.|     :|......:...:.||:||.|..|           |:|..|
  Fly   422 KAKMKTINWGKIPHNKVLGKQNIWSIVASNHQDSPMQDIDWNEMEGLFCLQTASAQGSPKLGRDG 486

  Fly   743 A-LRNGSNGTEVDGSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKL 806
            : ...||||.:.    ...|..|....::||:..|..|:.|..::.....||:|..|.....:::
  Fly   487 SQAAAGSNGCDT----LDRKSKKESTEITLLDGKRSLNVNIFLKQFRTSNDDIIQLIRQGAHEEI 547

  Fly   807 SLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVD 871
            ..|.:..|.|::|...|:...|.:   ..|:..|...:||:|||..|.....::..|.....|..
  Fly   548 GAERLRGLLKIMPEVDELDMLKGF---NGDKARLGNAEKFLLQLLEVPNYKLRIESMLLKEEFAA 609

  Fly   872 SVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNS-NKRGPAYGFKLQSLDTLIDTKST 935
            :|..:.|.:.|:..|...|..::..:.||.:|:..||:||| ...|.|.|.||.||..|.|.::.
  Fly   610 NVAYLEPCINSMLYAGDDLLNNKTLQEVLYMVVVAGNFLNSGGYAGNAAGVKLSSLQKLTDIRAN 674

  Fly   936 DKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAE---- 996
            ....:|:|::......:.||||.|..:|...:.|:....|.:..::..|:..:..:.::.|
  Fly   675 KPGMNLIHFVALQAEKRNPELLQFTGQLSNLESASKTTSEQINNEINTLDGRIRRIARQIEQPAT 739

  Fly   997 -LRVKGAQTHILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAF-----FALI 1055
             :.:|    ..:.|||..:|.:|..:::.::..:....:..|:|.|     |||.|     |.:.
  Fly   740 DVDIK----EQMADFLQAAESELSVLQAGMKQVESMRLKMSEFFCD-----DAATFRLEECFKIF 795

  Fly  1056 VRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINEL 1120
            ..|...|||..:|||:|.:.|:.|.|...::|........::.|....:..:....|.:|:.:..
  Fly   796 HNFCDKFKQAVKENERRQQQEQQATLRRKQREEQLARRARQIGQAGTPVSDSEHSFLGDAIFDPR 860

  Fly  1121 KSKAHSVREKKLLQQDEVYNGALEDILLGLKSEPYRRADAVRRSQRRRIDNNRLSRTLEEMD 1182
            .|.|.|.|.   |...|:.||.:.      ..:.....|.......||    |.||.|.|.|
  Fly   861 ASPALSRRH---LGSGEISNGFIR------LEQDGASPDITPNGSLRR----RRSRVLAEED 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	11/42 (26%)
		Drf_FH3	374..567	CDD:283917	50/267 (19%)
		FH2	687..1063	CDD:280362	99/404 (25%)
form3	NP_001097527.1	Drf_GBD	<1..43	CDD:283920	11/41 (27%)
		Drf_FH3	48..309	CDD:283917	51/272 (19%)
		FH2	415..803	CDD:280362	100/411 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45463913
Domainoid	1	1.000	79	1.000	Domainoid score	I2351
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.870