Protein Alignment Frl and Daam1

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_001420889.1
• Gene: Daam1 / 314212
• RGDID: 1305119
• Length: 1078
• Species: Rattus norvegicus
• Alignment Length: 1249
• Identity: 307/1249 - (24%)
• Similarity: 526/1249 - (42%)
• Gaps: 345/1249 - (27%)

  Fly    52 LRYDIGCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDM 116
            ||.|...:.|   ..:|:|      |||..:|||..|::::..:||.....:.:.....||||.:
  Rat    30 LRNDSNFALQ---TMEPAL------PMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQI 85

  Fly   117 ICDQEMVQAKDP-----PSHYLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLE 176
            .|.::..|.::.     |..|:.:|.:    .|:|...|.|     :|.:   |...::.:..|:
  Rat    86 YCSKKKDQEENKGATSWPEFYIDQLNS----MAARKSLLAL-----EKEE---EEERSKTIESLK 138

  Fly   177 ISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIV 241
            .:|||..:.:|..|:|     ||.|...|:| |:.|.:|
  Rat   139 TALRTKPMRFVTRFID-----LDGLSCILNF-LKTMDYE-------------------------- 171

  Fly   242 MGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIA 306
                                         |.:||
  Rat   172 -----------------------------TSESR------------------------------- 176

  Fly   307 KLNMGAATDDIHVSIM-CLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAIC 370
                      ||.|:: |::|:|||..|...|:.|.|:||.||.||..::::||..|||:|.|:|
  Rat   177 ----------IHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVC 231

  Fly   371 LVKGGHEIILGSFDNFKDVCQEKRRFQTL---MEYFMNFEAFNIDFMVACMQFMNIVVH---SVE 429
            ||.|||:.:|.:..:::....|:.|||||   ::.........:....|.|.|:|.|:.   .||
  Rat   232 LVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVE 296

  Fly   430 DMNYRVHLQYEFTALG---------------LDKYLE---------------------------- 451
            .:::|:||:|||..||               ||::|:
  Rat   297 SLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSAT 361

  Fly   452 ------RIRLTESEEL--------------------KVQISAYLDNVFDVAALMED--SETKTSA 488
                  |.|||.||..                    .||....||.:.....:..|  .:..::.
  Rat   362 QMFELTRRRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTP 426

  Fly   489 LE---------------RVQELEDQLEREIDRNSEFLYKYAELESESLTLKTEREQ----LAMIR 534
            ||               .|::.::|.|:....::|...|..:.|.|......|:|:    |..::
  Rat   427 LENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMK 491

  Fly   535 QKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSG 599
            :|||:|.|      :|.:.:.:..|.......:..:.:..|:|...|.|    |.||..  ..||
  Rat   492 EKLEKETT------EHKQVKQQVADLTAQLHELNRRAVCASVPGGPSPG----APGGPF--PPSG 544

  Fly   600 AASLTLPPPPPPMPASPTASSAAPPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPML 664
            ..|| |||||||:     .|..|.||||||.||..||||
  Rat   545 LGSL-LPPPPPPL-----LSGGALPPPPPPLPPGGPPPP-------------------------- 577

  Fly   665 SSFQPPPPPVAGFMPAPDG--AMTIKRK---VPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIF 724
                |.|||:.|.:|.|..  ::|:|:|   .||. .|.:.||..|..|::.||::.|:||.|:|
  Rat   578 ----PGPPPLGGILPPPGAPVSLTLKKKNIPQPTN-ALKSFNWSKLPENKLEGTVWTEIDDTKVF 637

  Fly   725 KQIDFNEFEERFKIGIGGA--------LRNGSNGTE---VDGSLQSSKRFKRPDNVSLLEHTRLR 778
            |.:|..:.|..|     .|        :.|.|...|   :|.:|.|..:.|   .:|:::..|.:
  Rat   638 KILDLEDLERTF-----SAYQRQQEFFVNNNSKQKEADAIDDALSSKLKVK---ELSVIDGRRAQ 694

  Fly   779 NIAISRRKLGMPIDDVIAAIHSLDLKK-LSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTE 842
            |..|...:|.:..|::..||.::|.:: |..:.:|.|.|.||..:::...:|:   :.:...:.:
  Rat   695 NCNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEH---KHELDRMAK 756

  Fly   843 EDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFG 907
            .|:|:.::||:.....:|..:.:...|.:.|..:.|:|::|..:|..:.:|...|.:||:|||||
  Rat   757 ADRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSSSEEVLRSSALKQLLEVVLAFG 821

  Fly   908 NYLNSNKRGPAYGFKLQSLDTLIDTKST-DKRSSLLHYIVATIRAKFPELLNFESELYGTDKAAS 971
            ||:|..:||.|||||:.||:.:.||||: ||..:||||::..:..|:|::||...||....:||.
  Rat   822 NYMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPKVLNLSEELRDIPQAAK 886

  Fly   972 VALENVVADVQELEKGMDLVRKEAELRVKGAQ--------THILRDFLNNSEDKLKKIKSDLRHA 1028
            |.:..:..::..|..|:..|  |.||..:.:|        ..::..|:..:......::..|..|
  Rat   887 VNMTELDKEISTLRSGLKAV--ETELEYQKSQPPQPGDKFVSVVSQFITLASFSFSDVEDLLAEA 949

  Fly  1029 QEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLM 1093
            :|.|.:.|::||:.:.......||.:..:|.:                   |:..:|:||:.:..
  Rat   950 KELFTKAVKHFGEEAGKIQPDEFFGIFDQFLQ-------------------AVTEAKQENENMRK 995

  Fly  1094 RNKVNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKS-EPYRR 1157
            |.:..:::.:|         ||.:.|.:.:...:|:.|...::   :|..:|::..|:| |.:.:
  Rat   996 RKEEEERRARL---------EAQLKEQRERERKMRKAKESSEE---SGEFDDLVSALRSGEVFDK 1048

  Fly  1158 ADAVRRSQRRRIDN 1171
            ..:..:..|:||.|
  Rat  1049 DLSKLKRNRKRISN 1062

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	67/299 (22%)
		Drf_FH3	374..567	CDD:461885	58/288 (20%)
		FH2	687..1063	CDD:396655	113/399 (28%)
Daam1	NP_001420889.1	Drf_GBD	45..232	CDD:461886	68/306 (22%)
		Drf_FH3	235..439	CDD:461885	41/203 (20%)
		PRK12704	444..>513	CDD:237177	17/74 (23%)
		FH2	600..983	CDD:396655	112/415 (27%)