DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Frl and Fmnl3

DIOPT Version :9

Sequence 1:	NP_729954.2	Gene:	Frl / 39561	FlyBaseID:	FBgn0267795	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	XP_017450814.1	Gene:	Fmnl3 / 300225	RGDID:	1583854	Length:	1087	Species:	Rattus norvegicus

Alignment Length:	1123	Identity:	481/1123 - (42%)
Similarity:	678/1123 - (60%)	Gaps:	149/1123 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 PSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHY 132
            |.|....:.|||...||:.|||.||:||:||||||:|||.||:|||||:|||||..|.|:||..|
  Rat    18 PLLLPPGKTPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTY 82

  Fly   133 LSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQG 197
            :.||:::|||..:|.          :.|:.|.|  ||:|||:||||||||||.||:|||:|.|:|
  Rat    83 IQKLQSFLDPNVTRK----------KFRRRVQE--STKVLRELEISLRTNHIGWVREFLNDENKG 135

  Fly   198 LDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGG-EIVMGNSSSVSPGGGGGLLSHGN 261
            ||.|||||||....:..:  .:|          |.:|.||. :.:...|.|:..      |...|
  Rat   136 LDVLVDYLSFAQCSVMFD--FEG----------LESGDDGAFDKLRSWSRSIED------LQPPN 182

  Fly   262 STGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLK--RRSRHIAKLNMGAATDDIHVSIMCL 324
            :......|....|.:|..:.|..|          |..:  :.||.:::      .||:||.|:||
  Rat   183 ALSAPFTNSLARSARQSVLRYSTL----------PGRRALKNSRLVSQ------KDDVHVCILCL 231

  Fly   325 RAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDV 389
            |||||.:||||:|:.|..|:|.|||||.:|:.||||||||||||:|||:|||||||.:|||||:|
  Rat   232 RAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEV 296

  Fly   390 CQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIR 454
            |:|..||:.|||||.| |..||||:||||||:|||||||||||:|||||||||.|||:::|::.|
  Rat   297 CKELHRFEKLMEYFRN-EDSNIDFLVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR 360

  Fly   455 LTESEELKVQISAYLDNVFDVAALMEDSETKTSALERVQELEDQL----EREIDRNSEFLYKYAE 515
            .||||:|:|||.|||||||||..|:||:|||..|||:|:|||:.:    |:.:|..:|.:.:.||
  Rat   361 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAE 425

  Fly   516 LESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSA 580
            ||.:.|..:.|.|.:....:....::..::|:::..|:..::|        ..|:..:|||  .:
  Rat   426 LEKQLLQREKELESIKETYENTSNQVHTLRRLIKEKEEAFQRR--------CHLEPSARSL--ES 480

  Fly   581 SSGDGSLANGG---LMAGSTSGAASLTLPPPPPPMPASPTASSAAPPPPPPPAPPAPPPPPGFSP 642
            ..|..:||..|   |..|||.....|..|.|    ||..|.     |.|||||||.|||||
  Rat   481 MGGSEALARVGPTELTEGSTPSDLDLLAPAP----PAEETL-----PLPPPPAPPLPPPPP---- 532

  Fly   643 LGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPD-----GAMTIKRKVPTKYKLPTLNW 702
                        |.|...        ||.||:.|..|:..     .|:.||:.:.||::||..||
  Rat   533 ------------PLPDKC--------PPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNW 577

  Fly   703 IALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRF-KRP 766
            .||||||:.||:|:|||||||.:.:|.::|||.||        ..:.|..:|.....:|.. |..
  Rat   578 TALKPNQINGTVFSELDDEKILEDLDLDKFEELFK--------TKAQGPALDLICSKNKTAQKAA 634

  Fly   767 DNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYI 831
            ..|:|||..|.:|:||:.||.|...:::..|||:.||:.|.::.||.|.:.:||:||||..::|.
  Rat   635 SKVTLLEANRAKNLAITLRKAGRTAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYE 699

  Fly   832 IERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKF 896
            .||:..:.|..||:|||..|:|||::.::|.|.::|||.|::.:::||:.:|..||.|:|.|:|.
  Rat   700 RERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKL 764

  Fly   897 KAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFES 961
            |.:|||:||.|||:||:|||..|||||||||.|:||||||::.:|||:|..|::.|:|||.||..
  Rat   765 KQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPELANFWQ 829

  Fly   962 ELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHILRDFLNNSEDKLKKIKSDLR 1026
            ||:..:|||:|:||||:.||:||.:||:|:|:|..:.    ...:||:||:.:|.||.|::.|.:
  Rat   830 ELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIH----DNSVLRNFLSTNEGKLDKLQRDAK 890

  Fly  1027 HAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQV 1091
            .|:||:...|.|||:|.:....:.||.:.|||.|::|:.:||||.|             |:.::|
  Rat   891 TAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEAR-------------KKQEEV 942

  Fly  1092 LMRNKVNQKKQQL----PSNGALSLQEAVINELKSKAHSVREKKLLQQDEVY---NGALEDILLG 1149
            :...::.|:.::|    ||......|:.:|.||       |.::..:...||   :||:|||:.|
  Rat   943 MREKQLAQEAKKLDAKTPSQRNKWQQQELIAEL-------RRRQAKEHRPVYEGKDGAIEDIITG 1000

  Fly  1150 LKSEPYRRADAVRRSQRR 1167
            ..    .....|..||.|
  Rat  1001 FN----HHQPMVTHSQAR 1014

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	134/296 (45%)
		Drf_FH3	374..567	CDD:283917	102/196 (52%)
		FH2	687..1063	CDD:280362	171/376 (45%)
Fmnl3	XP_017450814.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350423
Domainoid	1	1.000	343	1.000	Domainoid score	I1033
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	812	1.000	Inparanoid score	I454
OMA	1	1.010	-	-		QHG54599
OrthoDB	1	1.010	-	-		D149905at33208
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		otm45724
orthoMCL	1	0.900	-	-		OOG6_103315
Panther	1	1.100	-	-	O	PTHR45857
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X513
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.910