Protein Alignment Frl and Fmnl3

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_001386695.1
• Gene: Fmnl3 / 300225
• RGDID: 1583854
• Length: 1087
• Species: Rattus norvegicus
• Alignment Length: 1123
• Identity: 481/1123 - (42%)
• Similarity: 678/1123 - (60%)
• Gaps: 149/1123 - (13%)

  Fly    68 PSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHY 132
            |.|....:.|||...||:.|||.||:||:||||||:|||.||:|||||:|||||..|.|:||..|
  Rat    18 PLLLPPGKTPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTY 82

  Fly   133 LSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQG 197
            :.||:::|||..:|.          :.|:.|.|  ||:|||:||||||||||.||:|||:|.|:|
  Rat    83 IQKLQSFLDPNVTRK----------KFRRRVQE--STKVLRELEISLRTNHIGWVREFLNDENKG 135

  Fly   198 LDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGG-EIVMGNSSSVSPGGGGGLLSHGN 261
            ||.|||||||....:..:  .:|          |.:|.||. :.:...|.|:..      |...|
  Rat   136 LDVLVDYLSFAQCSVMFD--FEG----------LESGDDGAFDKLRSWSRSIED------LQPPN 182

  Fly   262 STGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLK--RRSRHIAKLNMGAATDDIHVSIMCL 324
            :......|....|.:|..:.|..|          |..:  :.||.:::      .||:||.|:||
  Rat   183 ALSAPFTNSLARSARQSVLRYSTL----------PGRRALKNSRLVSQ------KDDVHVCILCL 231

  Fly   325 RAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDV 389
            |||||.:||||:|:.|..|:|.|||||.:|:.||||||||||||:|||:|||||||.:|||||:|
  Rat   232 RAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEV 296

  Fly   390 CQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIR 454
            |:|..||:.|||||.| |..||||:||||||:|||||||||||:|||||||||.|||:::|::.|
  Rat   297 CKELHRFEKLMEYFRN-EDSNIDFLVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR 360

  Fly   455 LTESEELKVQISAYLDNVFDVAALMEDSETKTSALERVQELEDQL----EREIDRNSEFLYKYAE 515
            .||||:|:|||.|||||||||..|:||:|||..|||:|:|||:.:    |:.:|..:|.:.:.||
  Rat   361 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAE 425

  Fly   516 LESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSA 580
            ||.:.|..:.|.|.:....:....::..::|:::..|:..::|        ..|:..:|||  .:
  Rat   426 LEKQLLQREKELESIKETYENTSNQVHTLRRLIKEKEEAFQRR--------CHLEPSARSL--ES 480

  Fly   581 SSGDGSLANGG---LMAGSTSGAASLTLPPPPPPMPASPTASSAAPPPPPPPAPPAPPPPPGFSP 642
            ..|..:||..|   |..|||.....|..|.|    ||..|.     |.|||||||.|||||
  Rat   481 MGGSEALARVGPTELTEGSTPSDLDLLAPAP----PAEETL-----PLPPPPAPPLPPPPP---- 532

  Fly   643 LGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPD-----GAMTIKRKVPTKYKLPTLNW 702
                        |.|...        ||.||:.|..|:..     .|:.||:.:.||::||..||
  Rat   533 ------------PLPDKC--------PPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFNW 577

  Fly   703 IALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRF-KRP 766
            .||||||:.||:|:|||||||.:.:|.::|||.||        ..:.|..:|.....:|.. |..
  Rat   578 TALKPNQINGTVFSELDDEKILEDLDLDKFEELFK--------TKAQGPALDLICSKNKTAQKAA 634

  Fly   767 DNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYI 831
            ..|:|||..|.:|:||:.||.|...:::..|||:.||:.|.::.||.|.:.:||:||||..::|.
  Rat   635 SKVTLLEANRAKNLAITLRKAGRTAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQYE 699

  Fly   832 IERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKF 896
            .||:..:.|..||:|||..|:|||::.::|.|.::|||.|::.:::||:.:|..||.|:|.|:|.
  Rat   700 RERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQKL 764

  Fly   897 KAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFES 961
            |.:|||:||.|||:||:|||..|||||||||.|:||||||::.:|||:|..|::.|:|||.||..
  Rat   765 KQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPELANFWQ 829

  Fly   962 ELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHILRDFLNNSEDKLKKIKSDLR 1026
            ||:..:|||:|:||||:.||:||.:||:|:|:|..:.    ...:||:||:.:|.||.|::.|.:
  Rat   830 ELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIH----DNSVLRNFLSTNEGKLDKLQRDAK 890

  Fly  1027 HAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQV 1091
            .|:||:...|.|||:|.:....:.||.:.|||.|::|:.:||||.|             |:.::|
  Rat   891 TAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEAR-------------KKQEEV 942

  Fly  1092 LMRNKVNQKKQQL----PSNGALSLQEAVINELKSKAHSVREKKLLQQDEVY---NGALEDILLG 1149
            :...::.|:.::|    ||......|:.:|.||       |.::..:...||   :||:|||:.|
  Rat   943 MREKQLAQEAKKLDAKTPSQRNKWQQQELIAEL-------RRRQAKEHRPVYEGKDGAIEDIITG 1000

  Fly  1150 LKSEPYRRADAVRRSQRR 1167
            ..    .....|..||.|
  Rat  1001 FN----HHQPMVTHSQAR 1014

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	134/296 (45%)
		Drf_FH3	374..567	CDD:461885	102/196 (52%)
		FH2	687..1063	CDD:396655	171/376 (45%)
Fmnl3	NP_001386695.1	Drf_GBD	27..278	CDD:461886	134/296 (45%)
		Drf_FH3	281..472	CDD:461885	102/199 (51%)
		FH2	562..927	CDD:396655	171/376 (45%)