Protein Alignment Frl and Fmnl1

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_001426911.1
• Gene: Fmnl1 / 287746
• RGDID: 1311042
• Length: 1101
• Species: Rattus norvegicus
• Alignment Length: 1163
• Identity: 483/1163 - (41%)
• Similarity: 688/1163 - (59%)
• Gaps: 155/1163 - (13%)

  Fly    66 RQPSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPS 130
            :||::   .:||||...||:.||.:||..|:|||||.:||..||:||||::|||||..|.|:||:
  Rat    20 KQPAV---PKQPMPAAGELEERFTRVLNCMNLPPDKVQLLSQYDNEKKWELICDQERFQVKNPPA 81

  Fly   131 HYLSKLRTYLDP-KASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDT 194
            .|:.||::|||. ..||.........|..||::   ..||||||:||.|||||||.||:|||::.
  Rat    82 AYIQKLKSYLDTGGVSRKVATDWMSNLGFKRRV---QESTQVLRELETSLRTNHIGWVQEFLNEE 143

  Fly   195 NQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSH 259
            |:|||.|::||:|             ..|:....:..|..                      ::.
  Rat   144 NRGLDVLLEYLAF-------------AQCSVAYDMESTEN----------------------VAS 173

  Fly   260 GNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLK--------RRSRHIAKLNMGAATDD 316
            |......|.....|..:....|....|.|| ....||.|.        |.||.:::      .||
  Rat   174 GTEKNKPLEQSVEDLSKAPPSSVPKSRLTI-KCPPSPRLTPAHSRKALRNSRIVSQ------KDD 231

  Fly   317 IHVSIMCLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILG 381
            :||.|||||||||.:.||::|:.|...:|.|||||.:|:.||||||||||||:|||:|||:|||.
  Rat   232 VHVCIMCLRAIMNYQSGFSLVMNHPACVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHDIILA 296

  Fly   382 SFDNFKDVCQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGL 446
            :|||||:||.|:.||:.|||||.| |..|||||||||||:||||||||:||:||.||||||.|||
  Rat   297 AFDNFKEVCGEQHRFEKLMEYFRN-EDSNIDFMVACMQFINIVVHSVENMNFRVFLQYEFTHLGL 360

  Fly   447 DKYLERIRLTESEELKVQISAYLDNVFDVAALMEDSETKTSALERVQELEDQL----EREIDRNS 507
            |.||||:|||||::|:|||.|||||||||..|:|::|||.:.||.::||::|:    ||..|..:
  Rat   361 DLYLERLRLTESDKLQVQIQAYLDNVFDVGTLLEETETKNAVLEHMEELQEQVATLTERLRDTEN 425

  Fly   508 EFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQT- 571
            :.:.|.||||.:   |...|::|..:|::..|. |.|....:..|.|.....|::....:||:.
  Rat   426 DSMAKIAELEKQ---LSQARKELETLRERFSES-TPMVTSRRIPEPEKVPAPTVVRPSALELKVE 486

  Fly   572 ------LSR------------SLPRSAS--SGDGSLA-----NGGLMAGSTSGAASLTLPPPPPP 611
                  |.|            .||.:|:  |||.:.|     :....|.|...|||.|.||||||
  Rat   487 ELEEKGLIRILRGPGDVVSIEILPGAAATPSGDDAPAPRVSTDSPSTAESVPEAASPTPPPPPPP 551

  Fly   612 MP----------ASPTASSAAPPPP----PPPAPPAP---PPPPGFSPLGSPSGSLASTAPSPPH 659
            .|          |.|:|...|||.|    ||||||.|   ||||...|||       :..|.||.
  Rat   552 PPPLPNLQSQQEALPSAPPLAPPLPGCAAPPPAPPLPGDLPPPPPPPPLG-------TDGPVPPP 609

  Fly   660 APPMLSSFQPP--PPPVAGFM-PAPDGAMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDE 721
            .||      ||  ||.:.|.. |.....:..|:.:.||:::|.|||:||||:|:.||:|.||:||
  Rat   610 PPP------PPGGPPDILGGQDPEIGPGVKAKKPIQTKFRMPLLNWVALKPSQITGTVFTELNDE 668

  Fly   722 KIFKQIDFNEFEERFKIGIGGALRNGSNGTEVD-GSLQSSKRFKRPDNVSLLEHTRLRNIAISRR 785
            |:.:::|.|:|||:||        ..|.|..:| .:|:.....|.|...:|:|..|.:|:||:.|
  Rat   669 KVLQELDMNDFEEQFK--------TKSQGPSLDISALKGKTAHKAPTKATLIEANRAKNLAITLR 725

  Fly   786 KLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQL 850
            |..:..|.:..||.:.||:.|||:.:|||.:.:|||.|......:..|::..:.|:|||:|||:.
  Rat   726 KGNLGADRICEAIETYDLQTLSLDFLELLTRFLPTDYERSLIARFEKEQRPMEELSEEDRFMLRF 790

  Fly   851 SRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKR 915
            ||::|:..::..:.::|||.|:..|:.||:.:|..||.|:|.|.|.:.:||||||||||:||:||
  Rat   791 SRIQRLPERMNTLTFLGNFPDTAQLLMPQLNAIIAASISIKSSDKLRQILEIVLAFGNYMNSSKR 855

  Fly   916 GPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVAD 980
            |.||||:|||||.|::.||||::.:||||:|..|..|:|:|..|.|:|:..|||.||:|::|:.|
  Rat   856 GAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSDLHFLDKAGSVSLDSVLGD 920

  Fly   981 VQELEKGMDLVRKEAELRVKGAQTHILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRN 1045
            |:.|::|::|.::|.   |:.....:|::||..:...:.|:.:|.:.||||::..|||||::.:.
  Rat   921 VRSLQRGLELTQREF---VRQDDCLVLKEFLRANSPTMDKLLADSKTAQEAYESVVEYFGENPKT 982

  Fly  1046 ADAAAFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGAL 1110
            ...:.||:|..|||:|:|:.:||.||   .:|.||...|.:| :....::....::||:.
  Rat   983 TSPSMFFSLFSRFTKAYKKAEQEVEQ---WKKEAAADTSGRE-EPPAPKSPPKARRQQMD----- 1038

  Fly  1111 SLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKSEPYRRADAVRRSQRRR 1168
                 :|:|||.|  .::|..:.:.|.  :||:|||:..|:::||.|||..|||.|||
  Rat  1039 -----LISELKRK--QLKEPLIYESDR--DGAIEDIITDLRNQPYIRADTGRRSARRR 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	122/302 (40%)
		Drf_FH3	374..567	CDD:461885	106/196 (54%)
		FH2	687..1063	CDD:396655	157/376 (42%)
Fmnl1	NP_001426911.1	None