Protein Alignment Frl and cdc12

DIOPT Version :9

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_592869.1
• Gene: cdc12 / 2541603
• PomBaseID: SPAC1F5.04c
• Length: 1841
• Species: Schizosaccharomyces pombe
• Alignment Length: 1204
• Identity: 247/1204 - (20%)
• Similarity: 460/1204 - (38%)
• Gaps: 328/1204 - (27%)

  Fly   107 NYDDEKK------W-----DMICDQEMVQAKDPPSHYLSKLRTYLDPKASRSHRLYLFYFLCQKR 160
            |.:.||:      |     |:|.::|:  |:.|||   |..|.  ...:|.|:..:|.|  |
pombe   430 NAEYEKEVPLFFGWIKSFKDIILEKEL--ARTPPS---SPARN--SASSSPSNIAFLEY--C--- 482

  Fly   161 KMVGESTSTQVLRDLEISLRTNHIEWVKEFL---DDTNQGLDALVDYL-SFR-------LQMMRH 214
                  |||              :|::.:.:   ::..||.|  :|.| |.|       :|::|:
pombe   483 ------TST--------------MEFINQLIVACEELEQGFD--LDILDSLRESGIHEVIQLLRN 525

  Fly   215 --EQRLQ---GVLCASEERLNLT-NGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLD 273
              :|:|:   .:..:.|||..:: ...:..:..|.|.||:        ||..|..........|:
pombe   526 FPDQQLEKQLNIYESEEERRTISQTTHEDVDSFMSNESSI--------LSSFNEFASNEVGRLLE 582

  Fly   274 SRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKY------ 332
            |             ||.:.|.:...:::...:.|:          .:.:..|.::|:|.
pombe   583 S-------------TIQNILLAKGTEKQKVKLIKV----------FNSLLQRILLNSKVSNESFE 624

  Fly   333 -----GFNMVIQH----REAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSF----D 384
                 ..||:.:.    ..|.|.:..:...:::..| :|:|..|....|..|.|.::...    :
pombe   625 DSLQASLNMLTERFYSDDTARNALKEAKASRAMAEK-MVIERDAMAAQVNLGAEDLIAKLNKEVE 688

  Fly   385 NFKDV-CQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDK 448
            :.||| ..:||..:||..        .||.:...        |..:.....|.|:..:..:..|.
pombe   689 DQKDVILSQKRTNETLKT--------EIDALQKS--------HVTQIQRSEVELRELYLLINSDS 737

  Fly   449 Y------LERI---RLTESEELKVQISAYL---------DNVFDVAALMEDSETKTSALERVQEL 495
            :      .|||   .|.:.:..|.:|:|..         |.:.|:...|....::.|.:..:.::
pombe   738 FQGSTNSKERIIEYLLDKLDLRKKEIAAESTLWSNDGIDDKLRDLREQMSRQSSQPSTVSTILQI 802

  Fly   496 ED-QLEREIDRNSEFLYKY-AELESESLTLKTEREQLAMIRQKLEE--ELTVMQRMLQHNE--QE 554
            .| :..|...|:   |::| ....|||||  :|:::.....:.:::  .|.:..:.::.|.  ::
pombe   803 PDKKFHRPFPRH---LHRYVGRSASESLT--SEKDESIKSMKGIDDFANLEIPGKGIESNVVIKD 862

  Fly   555 LKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSGAASLT--LPPPPPPMPASPT 617
            :..:...:::...:.:|:         |.:..:.|..:...:||....:|  .||||||:|...:
pombe   863 ISNQTHEINSVENKAETV---------SNNSKITNFDIPNDATSLPTIITHPTPPPPPPLPVKTS 918

  Fly   618 ASSAAPPPP-------------PPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQP 669
            .::.:.|..             .|..||.|||||   ||.|.:|....:
pombe   919 LNTFSHPDSVNIVANDTSVAGVMPAFPPPPPPPP---PLVSAAGGKFVS---------------- 964

  Fly   670 PPPPVAGFMPAPDGAMT--IKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDE--KIFKQID-- 728
              |.|:..:...|...|  :.|: ||: :|..::|..|. :.:..|.:....||  ||.:.:.
pombe   965 --PAVSNNISKDDLHKTTGLTRR-PTR-RLKQMHWEKLN-SGLEFTFWTGPSDEANKILETLHTS 1024

  Fly   729 --FNEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPI 791
              .:|.:|.|      |::        :......|...|.|.:| .|..:|..|...:.....|.
pombe  1025 GVLDELDESF------AMK--------EAKTLVKKTCARTDYMS-SELQKLFGIHFHKLSHKNPN 1074

  Fly   792 DDVIAAIHSLD-----LKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLS 851
            :.:...:|..|     ::.||.:.| |.|..:..|.|     .|.|:..:...|...:|...:||
pombe  1075 EIIRMILHCDDSMNECVEFLSSDKV-LNQPKLKADLE-----PYRIDWANGGDLVNSEKDASELS 1133

  Fly   852 RVERISSKLAI---------MNYM--GNFVDS--VHLISPQVQSIAGASTSLKQSRKFKAVLEIV 903
            |.:.:..:|.:         ||.:  .|.:::  .:|:. |.:.|..|:..|:.|:.||.:|.::
pombe  1134 RWDYLYVRLIVDLGGYWNQRMNALKVKNIIETNYENLVR-QTKLIGRAALELRDSKVFKGLLYLI 1197

  Fly   904 LAFGNYLNSNKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDK 968
            |..|||:|...| .|.||.:.||..|...|:.:...||||.:..|||..||:..||..||....:
pombe  1198 LYLGNYMNDYVR-QAKGFAIGSLQRLPLIKNANNTKSLLHILDITIRKHFPQFDNFSPELSTVTE 1261

  Fly   969 AASVALENVVADVQELEKGMDLVRKEAELRVKGAQT------------HILRDFLNNSEDKLKKI 1021
            ||.:.:|.:..:..||.:|...::.:.:   .||.:            .::..:|.....|:..:
pombe  1262 AAKLNIEAIEQECSELIRGCQNLQIDCD---SGALSDPTVFHPDDKILSVILPWLMEGTKKMDFL 1323

  Fly  1022 KSDLRHAQEAFKECVEYFGDSSRNADAAAFF-----ALIVRFTRA----FKQHDQENEQRLRLEK 1077
            |..||.........:.|||:...:.::...|     :.|:.:::|    .|..::|..|..||
pombe  1324 KEHLRTMNTTLNNAMRYFGEQPNDPNSKNLFFKRVDSFIIDYSKARSDNLKSEEEEASQHRRL-- 1386

  Fly  1078 AAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGA 1142
                             |.||..|:.                       |.|:.:.:.:::.|.|
pombe  1387 -----------------NLVNNHKEH-----------------------VLERAMSENNKMDNEA 1411

  Fly  1143 LE---DILLGLKSEPY---RRADAVRRSQRRRID 1170
            ::   |.|..:|.|.:   |...|:...:...|:
pombe  1412 MDGFLDKLRNVKLESHHKPRNRSAITMGKEHLIE 1445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	60/306 (20%)
		Drf_FH3	374..567	CDD:283917	39/221 (18%)
		FH2	687..1063	CDD:280362	97/420 (23%)
cdc12	NP_592869.1	Drf_GBD	234..408	CDD:283920
		Drf_FH3	441..638	CDD:283917	51/261 (20%)
		FH2	981..1427	CDD:214697	114/516 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	79	1.000	Domainoid score	I2351
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54599
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.950