DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Frl and Fhod1

DIOPT Version :9

Sequence 1:	NP_729954.2	Gene:	Frl / 39561	FlyBaseID:	FBgn0267795	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	XP_036009863.1	Gene:	Fhod1 / 234686	MGIID:	2679008	Length:	1223	Species:	Mus musculus

Alignment Length:	697	Identity:	166/697 - (23%)
Similarity:	278/697 - (39%)	Gaps:	146/697 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   554 ELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSGAASLTLPPPPPPMPASPTA 618
            |.:.:|||    |:|.....::.|..:|           ::.|.||.     ||||||.|  |..
Mouse   581 EDEDQDTL----NVESVEAGKASPFLSS-----------LSPSLSGG-----PPPPPPPP--PPI 623

  Fly   619 SSAAPPPPPPPAPP-----APPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFM 678
            :.:.|||||||.||     .||||                   ||..||::.|..||||..|.|.
Mouse   624 TGSCPPPPPPPLPPPATGSCPPPP-------------------PPPPPPIIGSCPPPPPLAAPFT 669

  Fly   679 -PAPDGAMTIKRKVPTKYKLPTLNWIALK----PNQVRG------TIFNELDDEKIFKQIDFNEF 732
             .|.||.     :.|||.|...|.|..||    |...|.      |::..|:.    ..:|....
Mouse   670 HSALDGP-----RHPTKRKTVKLFWRELKLTGGPGCSRSRFGPCPTLWASLEP----VSVDTARL 725

  Fly   733 EERFKIGIGGALRNGSNGTEVDGSLQSSKRFK-RPDNVSLLEHTRLRNIAISRRKLGMPIDDVIA 796
            |..|:          |...:|   |.:.|..: |.....:|:..|...|.|....| .|:..:.|
Mouse   726 EHLFE----------SRAKDV---LPTKKAGEGRRTMTVVLDPKRSNAINIGLTTL-PPVHVIKA 776

  Fly   797 AIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLA 861
            |:.:.|...:|.:.:|.|..|:||:.|.:..:|..:...|..|...|: |::.|:.:..::::|.
Mouse   777 ALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDVPLGPAEN-FLMTLASIGGLAARLQ 840

  Fly   862 IMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQSL 926
            :..:..::......|:..:..:......|..:..|:.:|..:||.||:||.::   :.||:|..|
Mouse   841 LWAFKLDYESMEREIAEPLFDLKVGMEQLVHNATFRCILATLLAVGNFLNGSQ---SSGFELSYL 902

  Fly   927 DTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELE----KG 987
            :.:.:.|.|.:|.|||:::.:.:....|:..:..||:....:.|.|..|.:..::.:||    ..
Mouse   903 EKVSEVKDTVRRQSLLYHLCSLVLQTRPDSSDLYSEIPALTRCAKVDFEQLTENLGQLECRSQAA 967

  Fly   988 MDLVRKEAELRVKGAQTHILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFG---DSSRNADAA 1049
            .|.:|..|:..:..|....|..||.....::..::...|.....|...:.|.|   .::|:....
Mouse   968 EDSLRSLAKHELSPALRARLTHFLAQCTRRVAMLRVVHRRVCNRFHAFLLYLGYTPQAARDVRIM 1032

  Fly  1050 AF------FALIVRFTRAFKQHDQE--------NEQRLRL----EKAAALAASKKENDQVLMRNK 1096
            .|      |||..|..|......|:        |:.|.|:    ||.:.:|.....|..|.:  .
Mouse  1033 QFCHTLREFALEYRTCRERVLQQQQKRATYRERNKTRGRMITETEKFSGVAGEAPNNLSVPV--A 1095

  Fly  1097 VNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQ--------------------------- 1134
            |.....|..::...|::..:.:..:...||.|.:.::|
Mouse  1096 VGSGPGQGDTDNHASMKSLLTSRPEDATHSRRSRGMVQSSSPVSHTAVGPSAASPEETAASGLPT 1160

  Fly  1135 --QDEVYNGALEDILLGLKSEPYRRADAVRRSQRRRIDNNRLSRTLE 1179
              .||:.:..::.:   .||.|  ||.|.|..:|.|.:...|.|||:
Mouse  1161 DTSDEIMDLLVQSV---TKSGP--RALAARERKRSRGNRKSLRRTLK 1202

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920
		Drf_FH3	374..567	CDD:283917	4/12 (33%)
		FH2	687..1063	CDD:280362	89/399 (22%)
Fhod1	XP_036009863.1	Formin_GBD_N	17..115	CDD:408182
Fhod1	XP_036009863.1	FH2	674..1046	CDD:396655	89/398 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167846928
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840