Protein Alignment Frl and FNBP4

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_001428029.1
• Gene: FNBP4 / 23360
• HGNCID: 19752
• Length: 1092
• Species: Homo sapiens
• Alignment Length: 1084
• Identity: 184/1084 - (16%)
• Similarity: 287/1084 - (26%)
• Gaps: 519/1084 - (47%)

  Fly    39 NGSISSGT--LQKQDLRYDIGCS------------------SQYQHVRQPSLRSRSQQPMPTTDE 83
            :.|.|:||  .|....:||..||                  ||.|.:..|....:.....|||
Human   189 SSSTSNGTDSTQTSGWQYDTQCSLAGGWSAVMRSRLTATSASQVQPILLPQSPEQLGLQAPTT-- 251

  Fly    84 LDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHYLSKLRTYLDPKASRSH 148
            ...:|...|..|           .:.|..|..:    |::.:.|||              ||.|
Human   252 TPSKFFVFLVEM-----------GFHDVGKAGL----ELLTSGDPP--------------ASAS- 286

  Fly   149 RLYLFYFLCQKRKMVG-ESTSTQVLRDLEI------SLRTNHIEWVKEFLDDTNQGLDALVDYLS 206
                         .|| |....|.:.|...      :.:||.:.|             .|..||:
Human   287 -------------QVGIEMGDWQEVWDENTGCYYYWNTQTNEVTW-------------ELPQYLA 325

  Fly   207 FRLQMMRHEQ--RLQGVLCA--------SEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGN 261
            .::|.::|.|  .:.|...:        |:|:....:....|.::...........|...||:..
Human   326 TQVQGLQHYQPSSVPGAETSFVVNTDIYSKEKTISVSSSKSGPVIAKREVKKEVNEGIQALSNSE 390

  Fly   262 STGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRA 326
            ....|:|             ...|.|.:.:.:.....:.|.:.|.|
Human   391 EEKKGVA-------------ASLLAPLLPEGIKEEEERWRRKVICK------------------- 423

  Fly   327 IMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDVCQ 391
                          .|.::.:.        .|...|.|   |..:|| ..||:|   ||.:|..|
Human   424 --------------EEPVSEVK--------ETSTTVEE---ATTIVK-PQEIML---DNIEDPSQ 459

  Fly   392 ------------EKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTAL 444
                        |:...|..:|..:..|....:     ::.:.....||...:.|..:....:..
Human   460 EDLCSVVQSGESEEEEEQDTLELELVLERKKAE-----LRALEEGDGSVSGSSPRSDISQPASQD 519

  Fly   445 GLDKYLER-------IRLTESEEL---------------KVQISAYLDNVFDVAALMEDSETKTS 487
            |:.:.:.:       :|.|..|..               :..|.|......|     |:|:.:..
Human   520 GMRRLMSKRGKWKMFVRATSPESTSRSSSKTGRDTPENGETAIGAENSEKID-----ENSDKEME 579

  Fly   488 ALERVQELEDQLEREIDRNSEFLYKYAELESESLTLKTEREQLAMIRQK--------LEEELTV- 543
            ..|..::::.|...:::...:..::..||.:   ||.::.|.|.:.||.        |:.|..:
Human   580 VEESPEKIKVQTTPKVEEEQDLKFQIGELAN---TLTSKFEFLGINRQSISNFHVLLLQTETRIA 641

  Fly   544 -----------MQRMLQHNEQELKK---------------RDTLLHTK----------------- 565
                       ::|.||...::||:               ||   |.:
Human   642 DWREGALNGNYLKRKLQDAAEQLKQYEINATPKGWSCHWDRD---HRRYFYVNEQSGESQWEFPD 703

  Fly   566 ----------------NMELQTLSRSLPRSASSGDGS-LANGGLMAGSTSGAAS----------- 602
                            .:..|||.......::|.:.| .:.|.|...|.||..|
Human   704 GEEEEEESQAQENRDETLAKQTLKDKTGTDSNSTESSETSTGSLCKESFSGQVSSSSLMPLTPFW 768

  Fly   603 ---------------LTLPPPPPPMPASPTASSAAPPPPPPPAPPA----------------PPP 636
                           |.:||||||.|.|       |||||||.|||                .||
Human   769 TLLQSNVPVLQPPLPLEMPPPPPPPPES-------PPPPPPPPPPAEDGEIQEVEMEDEGSEEPP 826

  Fly   637 PPGFS------------------------------------------------------------ 641
            .||..
Human   827 APGTEEDTPLKPSAQTTVVTSQSSVDSTISSSSSTKGIKRKATEISTAVVQRSATIGSSPVLYSQ 891

  Fly   642 ------------------------PLGSPSG---------SLAS--------------------- 652
                                    |:..|:.         ||.|
Human   892 SAIATGHQAAGIGNQATGIGHQTIPVSLPAAGMGHQARGMSLQSNYLGLAAAPAIMSYAECSVPI 956

  Fly   653 --TAPS------------------PPHAPPMLSSFQPPPPPVAGFMPAP--------DGAMTIKR 689
              ||||                  ||..||     .|||||.|..||.|        |.|...|.
Human   957 GVTAPSLQPVQARGAVPTATIIEPPPPPPP-----PPPPPPPAPKMPPPEKTKKGRKDKAKKSKT 1016

  Fly   690 KVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVD 754
            |:|:..|    .|.:::         .|||:|                        :.|:.:|.|
Human  1017 KMPSLVK----KWQSIQ---------RELDEE------------------------DNSSSSEED 1044

  Fly   755 GSLQSSKRFKRPDNVSLLEHTRLRN-----------IAISRRKL 787
            ....:.||.:......|:.....||           ..:.|||:
Human  1045 RESTAQKRIEEWKQQQLVSGMAERNANFEALPEDWRARLKRRKM 1088

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	48/310 (15%)
		Drf_FH3	374..567	CDD:461885	43/294 (15%)
		FH2	687..1063	CDD:396655	20/112 (18%)
FNBP4	NP_001428029.1	None