DRSC/TRiP Functional Genomics Resources

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Protein Alignment Frl and DAAM1

DIOPT Version :9

Sequence 1:NP_729954.2 Gene:Frl / 39561 FlyBaseID:FBgn0267795 Length:1183 Species:Drosophila melanogaster
Sequence 2:NP_055807.1 Gene:DAAM1 / 23002 HGNCID:18142 Length:1078 Species:Homo sapiens


Alignment Length:1254 Identity:307/1254 - (24%)
Similarity:521/1254 - (41%) Gaps:339/1254 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 LRYDIGCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDM 116
            ||.|...:.|   ..:|:|      |||..:|||..|::::..:||.....:.:.....||||.:
Human    30 LRNDSNFALQ---TMEPAL------PMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQI 85

  Fly   117 ICDQEMVQAKDP-----PSHYLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLE 176
            .|.::..|.::.     |..|:.:|.:    .|:|...|.|     :|.:   |...::.:..|:
Human    86 YCSKKKDQEENKGATSWPEFYIDQLNS----MAARKSLLAL-----EKEE---EEERSKTIESLK 138

  Fly   177 ISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIV 241
            .:|||..:.:|..|:|     ||.|...|:| |:.|.:|                          
Human   139 TALRTKPMRFVTRFID-----LDGLSCILNF-LKTMDYE-------------------------- 171

  Fly   242 MGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIA 306
                                         |.:||                               
Human   172 -----------------------------TSESR------------------------------- 176

  Fly   307 KLNMGAATDDIHVSIM-CLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAIC 370
                      ||.|:: |::|:|||..|...|:.|.|:||.||.||..::::||..|||:|.|:|
Human   177 ----------IHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVC 231

  Fly   371 LVKGGHEIILGSFDNFKDVCQEKRRFQTL---MEYFMNFEAFNIDFMVACMQFMNIVVH---SVE 429
            ||.|||:.:|.:..:::....|:.|||||   ::.........:....|.|.|:|.|:.   .||
Human   232 LVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVE 296

  Fly   430 DMNYRVHLQYEFTALG---------------LDKYLE---------------------------- 451
            .:::|:||:|||..||               ||::|:                            
Human   297 SLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSAT 361

  Fly   452 ------RIRLTESEEL--------------------KVQISAYLDNVFDVAALMED--SETKTSA 488
                  |.|||.||..                    .||....||.:.....:..|  .:..::.
Human   362 QMFELTRKRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTP 426

  Fly   489 LE---------------RVQELEDQLEREIDRNSEFLYKYAELESESLTLKTEREQ----LAMIR 534
            ||               .|::.::|.|:....::|...|..:.|.|......|:|:    |..::
Human   427 LENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMK 491

  Fly   535 QKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSG 599
            :|||:|.|      :|.:.:.:..|.......:..:.:..|:|...|.|    |.||....|..|
Human   492 EKLEKETT------EHKQVKQQVADLTAQLHELSRRAVCASIPGGPSPG----APGGPFPSSVPG 546

  Fly   600 AASLTLPPPPPPMPASPTASSAAPPPPPPPAPP-APPPPPGFSPLGSPSGSLASTAPSPPHAPPM 663
              ||..||||||:|....      ||||||.|| .||||||                     ||.
Human   547 --SLLPPPPPPPLPGGML------PPPPPPLPPGGPPPPPG---------------------PPP 582

  Fly   664 LSSFQPPPPPVAGFMPAPDGAMTIKRKVPTKYK-LPTLNWIALKPNQVRGTIFNELDDEKIFKQI 727
            |.:..|||       .||.|....|:.:|.... |.:.||..|..|::.||::.|:||.|:||.:
Human   583 LGAIMPPP-------GAPMGLALKKKSIPQPTNALKSFNWSKLPENKLEGTVWTEIDDTKVFKIL 640

  Fly   728 DFNEFEERFKIGIGGALRN------GSNGTE-----VDGSLQSSKRFKRPDNVSLLEHTRLRNIA 781
            |..:.|..|     .|.:.      .||..:     :|.:|.|..:.|   .:|:::..|.:|..
Human   641 DLEDLERTF-----SAYQRQQDFFVNSNSKQKEADAIDDTLSSKLKVK---ELSVIDGRRAQNCN 697

  Fly   782 ISRRKLGMPIDDVIAAIHSLDLKK-LSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDK 845
            |...:|.:..|::..||.::|.:: |..:.:|.|.|.||..:::...:|:   :.:...:.:.|:
Human   698 ILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEH---KHELDRMAKADR 759

  Fly   846 FMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYL 910
            |:.::||:.....:|..:.:...|.:.|..:.|:|::|...|..:.:|...|.:||:|||||||:
Human   760 FLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSGALKQLLEVVLAFGNYM 824

  Fly   911 NSNKRGPAYGFKLQSLDTLIDTKST-DKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVAL 974
            |..:||.|||||:.||:.:.||||: ||..:||||::..:..|:|.:||...||....:||.|.:
Human   825 NKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPSVLNLNEELRDIPQAAKVNM 889

  Fly   975 ENVVADVQELEKGMDLVRKEAELRVKGAQ--------THILRDFLNNSEDKLKKIKSDLRHAQEA 1031
            ..:..::..|..|:..|  |.||..:.:|        ..::..|:..:......::..|..|::.
Human   890 TELDKEISTLRSGLKAV--ETELEYQKSQPPQPGDKFVSVVSQFITVASFSFSDVEDLLAEAKDL 952

  Fly  1032 FKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMRNK 1096
            |.:.|::||:.:.......||.:..:|.:|..:..||||.                     ||.|
Human   953 FTKAVKHFGEEAGKIQPDEFFGIFDQFLQAVSEAKQENEN---------------------MRKK 996

  Fly  1097 VNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKS-EPYRRADA 1160
            ..:::::       :..||.:.|.:.:...:|:.|   ::...:|..:|::..|:| |.:.:..:
Human   997 KEEEERR-------ARMEAQLKEQRERERKMRKAK---ENSEESGEFDDLVSALRSGEVFDKDLS 1051

  Fly  1161 VRRSQRRRIDNNRLSRTLE 1179
            ..:..|:||.|.....:.|
Human  1052 KLKRNRKRITNQMTDSSRE 1070

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FrlNP_729954.2 Drf_GBD 77..371 CDD:283920 67/299 (22%)
Drf_FH3 374..567 CDD:283917 58/288 (20%)
FH2 687..1063 CDD:280362 110/397 (28%)
DAAM1NP_055807.1 Drf_GBD 45..232 CDD:368864 68/306 (22%)
Drf_FH3 235..439 CDD:368862 41/203 (20%)
PRK12704 444..>513 CDD:237177 17/74 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 456..480 4/23 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 524..585 35/93 (38%)
FH2 600..984 CDD:366959 110/396 (28%)
Actin-binding 693..702 2/8 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 987..1034 13/77 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1055..1078 5/16 (31%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG54599
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000085
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3069
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.950

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