Protein Alignment Frl and Fmnl3

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_035841.1
• Gene: Fmnl3 / 22379
• MGIID: 109569
• Length: 1028
• Species: Mus musculus
• Alignment Length: 1122
• Identity: 481/1122 - (42%)
• Similarity: 679/1122 - (60%)
• Gaps: 148/1122 - (13%)

  Fly    68 PSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHY 132
            |.|....:.|||...||:.|||.||:||:||||||:|||.||:|||||:|||||..|.|:||..|
Mouse    18 PLLLPPGKTPMPEPCELEERFALVLSSMNLPPDKARLLRQYDNEKKWDLICDQERFQVKNPPHTY 82

  Fly   133 LSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQG 197
            :.||:::|||..:|.          :.|:.|.|  ||:|||:||||||||||.||:|||:|.|:|
Mouse    83 IQKLQSFLDPNVTRK----------KFRRRVQE--STKVLRELEISLRTNHIGWVREFLNDENKG 135

  Fly   198 LDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGG-EIVMGNSSSVSPGGGGGLLSHGN 261
            ||.|||||||....:..:  .:|          |.:|.||. :.:...|.|:..      |...|
Mouse   136 LDVLVDYLSFAQCSVMFD--FEG----------LESGDDGAFDKLRSWSRSIED------LQPPN 182

  Fly   262 STGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLK--RRSRHIAKLNMGAATDDIHVSIMCL 324
            :......|....|.:|..:.|..|          |..:  :.||.:::      .||:||.|:||
Mouse   183 ALSAPFTNSLARSARQSVLRYSTL----------PGRRALKNSRLVSQ------KDDVHVCILCL 231

  Fly   325 RAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDV 389
            |||||.:||||:|:.|..|:|.|||||.:|:.||||||||||||:|||:|||||||.:|||||:|
Mouse   232 RAIMNYQYGFNLVMSHPHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILAAFDNFKEV 296

  Fly   390 CQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIR 454
            |:|..||:.|||||.| |..|||||||||||:|||||||||||:|||||||||.|||:::|::.|
Mouse   297 CKELHRFEKLMEYFRN-EDSNIDFMVACMQFINIVVHSVEDMNFRVHLQYEFTKLGLEEFLQKSR 360

  Fly   455 LTESEELKVQISAYLDNVFDVAALMEDSETKTSALERVQELEDQL----EREIDRNSEFLYKYAE 515
            .||||:|:|||.|||||||||..|:||:|||..|||:|:|||:.:    |:.:|..:|.:.:.||
Mouse   361 HTESEKLQVQIQAYLDNVFDVGGLLEDAETKNVALEKVEELEEHVSHLTEKLLDLENENMMRVAE 425

  Fly   516 LESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSA 580
            ||.:.|..:.|.|.:....:....::..::|:::..|:..::|        ..|:..:|.|   .
Mouse   426 LEKQLLQREKELESIKETYENTSNQVHTLRRLIKEKEEAFQRR--------CHLEPSARGL---E 479

  Fly   581 SSGDGSLANGGLMAGSTSGAASLTLPPPPPPM----PASPTASSAAPPPPPPPAPPAPPPPPGFS 641
            |.|..:||.        .|...||...||..:    ||.||..:.  |.|||||||.|||||
Mouse   480 SMGGEALAR--------VGPTELTEGIPPSDLDLLAPAPPTEETL--PLPPPPAPPLPPPPP--- 531

  Fly   642 PLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPD-----GAMTIKRKVPTKYKLPTLN 701
                         |.|...        ||.||:.|..|:..     .|:.||:.:.||::||..|
Mouse   532 -------------PLPDKC--------PPAPPLPGAAPSVVLTVGLSAIRIKKPIKTKFRLPVFN 575

  Fly   702 WIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRF-KR 765
            |.||||||:.||:|:|||||||.:.:|.:.|||.||        ..:.|..:|.....:|.. |.
Mouse   576 WTALKPNQINGTVFSELDDEKILEDLDLDRFEELFK--------TKAQGPALDLICSKNKTAQKA 632

  Fly   766 PDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEY 830
            ...|:|||..|.:|:||:.||.|...:::..|||:.||:.|.::.||.|.:.:||:||||..::|
Mouse   633 ASKVTLLEANRAKNLAITLRKAGRSAEEICRAIHTFDLQTLPVDFVECLMRFLPTEAEVKLLRQY 697

  Fly   831 IIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRK 895
            ..||:..:.|..||:|||..|:|||::.::|.|.::|||.|::.:::||:.:|..||.|:|.|:|
Mouse   698 ERERQPLEELAAEDRFMLLFSKVERLTQRMAGMAFLGNFQDNLQMLTPQLNAIIAASASVKSSQK 762

  Fly   896 FKAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFE 960
            .|.:|||:||.|||:||:|||..|||||||||.|:||||||::.:|||:|..|::.|:|||.||.
Mouse   763 LKQMLEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKMTLLHFIALTVKEKYPELANFW 827

  Fly   961 SELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHILRDFLNNSEDKLKKIKSDL 1025
            .||:..:|||:|:||||:.||:||.:||:|:|:|..:.    ...:||:||:.:|.||.|::.|.
Mouse   828 QELHFVEKAAAVSLENVLLDVKELGRGMELIRRECSIH----DNSVLRNFLSTNEGKLDKLQRDA 888

  Fly  1026 RHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQ 1090
            :.|:||:...|.|||:|.:....:.||.:.|||.|::|:.:||||.|             |:.::
Mouse   889 KTAEEAYNAVVRYFGESPKTTPPSVFFPVFVRFIRSYKEAEQENEAR-------------KKQEE 940

  Fly  1091 VLMRNKVNQKKQQL----PSNGALSLQEAVINELKSKAHSVREKKLLQQDEVY---NGALEDILL 1148
            |:...::.|:.::|    ||......|:.:|.||       |.::..:...||   :|.:|||:.
Mouse   941 VMREKQLAQEAKKLDAKTPSQRNKWQQQELIAEL-------RRRQAKEHRPVYEGKDGTIEDIIT 998

  Fly  1149 GLKSEPYRRADAVRRSQ 1165
            .|||.|:....|.|.|:
Mouse   999 VLKSVPFTARTAKRGSR 1015

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	134/296 (45%)
		Drf_FH3	374..567	CDD:461885	103/196 (53%)
		FH2	687..1063	CDD:396655	171/376 (45%)
Fmnl3	NP_035841.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28		2/9 (22%)
		Drf_GBD	27..278	CDD:461886	134/296 (45%)
		Drf_FH3	281..472	CDD:461885	103/199 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	493..541		25/73 (34%)
		FH2	561..926	CDD:396655	171/376 (45%)