DRSC/TRiP Functional Genomics Resources

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Protein Alignment Frl and Daam1

DIOPT Version :10

Sequence 1:NP_729954.2 Gene:Frl / 39561 FlyBaseID:FBgn0267795 Length:1183 Species:Drosophila melanogaster
Sequence 2:NP_080378.2 Gene:Daam1 / 208846 MGIID:1914596 Length:1077 Species:Mus musculus


Alignment Length:1248 Identity:309/1248 - (24%)
Similarity:528/1248 - (42%) Gaps:344/1248 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    52 LRYDIGCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDM 116
            ||.|...:.|   ..:|:|      |||..:|||..|::::..:||.....:.:.....||||.:
Mouse    30 LRNDSNFALQ---TMEPAL------PMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQI 85

  Fly   117 ICDQEMVQAKDP-----PSHYLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLE 176
            .|.::..|.::.     |..|:.:|.:    .|:|...|.|     :|.:   |...::.:..|:
Mouse    86 YCSKKKDQEENKGATSWPEFYIDQLNS----MAARKSLLAL-----EKEE---EEERSKTIESLK 138

  Fly   177 ISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIV 241
            .:|||..:.:|..|:|     ||.|...|:| |:.|.:|                          
Mouse   139 TALRTKPMRFVTRFID-----LDGLSCILNF-LKTMDYE-------------------------- 171

  Fly   242 MGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIA 306
                                         |.:||                               
Mouse   172 -----------------------------TSESR------------------------------- 176

  Fly   307 KLNMGAATDDIHVSIM-CLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAIC 370
                      ||.|:: |::|:|||..|...|:.|.|:||.||.||..::::||..|||:|.|:|
Mouse   177 ----------IHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVC 231

  Fly   371 LVKGGHEIILGSFDNFKDVCQEKRRFQTL---MEYFMNFEAFNIDFMVACMQFMNIVVH---SVE 429
            ||.|||:.:|.:..:::....|:.|||||   ::.........:....|.|.|:|.|:.   .||
Mouse   232 LVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVE 296

  Fly   430 DMNYRVHLQYEFTALG---------------LDKYLE---------------------------- 451
            .:::|:||:|||..||               ||::|:                            
Mouse   297 SLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSAT 361

  Fly   452 ------RIRLTESEEL--------------------KVQISAYLDNVFDVAALMED--SETKTSA 488
                  |.|||.||..                    .||....||.:.....:..|  .:..::.
Mouse   362 QMFELTRRRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTP 426

  Fly   489 LE---------------RVQELEDQLEREIDRNSEFLYKYAELESESLTLKTEREQ----LAMIR 534
            ||               .|::.::|.|:....::|...|..:.|.|......|:|:    |..::
Mouse   427 LENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMK 491

  Fly   535 QKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSG 599
            :|||:|.|      :|.:.:.:..|.......:..:.:..::|...|.|    |.||..  .:||
Mouse   492 EKLEKETT------EHKQVKQQVADLTAQLHELNRRAVCAAVPGGPSPG----APGGPF--PSSG 544

  Fly   600 AASLTLPPPPPPMPASPTASSAAPPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPML 664
            ..|| |||||||:     .|..|.||||||.||..||||                          
Mouse   545 LGSL-LPPPPPPL-----LSGGALPPPPPPLPPGGPPPP-------------------------- 577

  Fly   665 SSFQPPPPPVAGFMPAPDG--AMTIKRK---VPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIF 724
                |.|||:.|.:|.|..  ::|:|:|   .||. .|.:.||..|..|::.||::.|:||.|:|
Mouse   578 ----PGPPPLGGVLPPPGAPVSLTLKKKNIPQPTN-ALKSFNWSKLPENKLDGTVWTEIDDTKVF 637

  Fly   725 KQIDFNEFEERFKIGIGGALR-------NGSNGTE---VDGSLQSSKRFKRPDNVSLLEHTRLRN 779
            |.:|..:.|..|     .|.:       |.|...|   :|.:|.|..:.|   .:|:::..|.:|
Mouse   638 KILDLEDLERTF-----SAYQRQQEFFVNNSKQKEADAIDDTLSSKLKVK---ELSVIDGRRAQN 694

  Fly   780 IAISRRKLGMPIDDVIAAIHSLDLKK-LSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEE 843
            ..|...:|.:..|::..||.::|.:: |..:.:|.|.|.||..:::...:|:   :.:...:.:.
Mouse   695 CNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEH---KHELDRMAKA 756

  Fly   844 DKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGN 908
            |:|:.::||:.....:|..:.:...|.:.|..:.|:|::|...|..:.:||..|.:||:||||||
Mouse   757 DRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSRALKQLLEVVLAFGN 821

  Fly   909 YLNSNKRGPAYGFKLQSLDTLIDTKST-DKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASV 972
            |:|..:||.|||||:.||:.:.||||: ||..:||||::..:..|:|::||...||....:||.|
Mouse   822 YMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPKVLNLSEELRDIPQAAKV 886

  Fly   973 ALENVVADVQELEKGMDLVRKEAELRVKGAQ--------THILRDFLNNSEDKLKKIKSDLRHAQ 1029
            .:..:..::..|..|:..|  |.||..:.:|        ..::..|:..:......::..|..|:
Mouse   887 NMTELDKEISTLRSGLKAV--ETELEYQKSQPPQPGDKFVSVVSQFITLASFSFSDVEDLLAEAK 949

  Fly  1030 EAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMR 1094
            |.|.:.|::||:.:.......||.:..:|.:                   |:|.:|:||:.:..|
Mouse   950 ELFTKAVKHFGEEAGKIQPDEFFGIFDQFLQ-------------------AVAEAKQENENMRKR 995

  Fly  1095 NKVNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKS-EPYRRA 1158
            .:..:::.:|         ||.:.|.:.:...||:.|...::   :|..:|::..|:| |.:.:.
Mouse   996 KEEEERRARL---------EAQLKEQRERERKVRKAKESSEE---SGEFDDLVSALRSGEVFDKD 1048

  Fly  1159 DAVRRSQRRRIDN 1171
            .:..:..|:||.|
Mouse  1049 LSKLKRNRKRISN 1061

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FrlNP_729954.2 Drf_GBD 77..371 CDD:461886 67/299 (22%)
Drf_FH3 374..567 CDD:461885 58/288 (20%)
FH2 687..1063 CDD:396655 114/398 (29%)
Daam1NP_080378.2 Drf_GBD 45..232 CDD:461886 68/306 (22%)
Drf_FH3 235..439 CDD:461885 41/203 (20%)
PRK12704 444..>513 CDD:237177 17/74 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 457..478 4/20 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 526..596 38/111 (34%)
FH2 600..982 CDD:396655 113/414 (27%)
Actin-binding. /evidence=ECO:0000250 693..702 2/8 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1007..1033 6/28 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1056..1077 4/6 (67%)

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