Protein Alignment Frl and Daam1

DIOPT Version :9

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_080378.2
• Gene: Daam1 / 208846
• MGIID: 1914596
• Length: 1077
• Species: Mus musculus
• Alignment Length: 1248
• Identity: 309/1248 - (24%)
• Similarity: 528/1248 - (42%)
• Gaps: 344/1248 - (27%)

  Fly    52 LRYDIGCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDM 116
            ||.|...:.|   ..:|:|      |||..:|||..|::::..:||.....:.:.....||||.:
Mouse    30 LRNDSNFALQ---TMEPAL------PMPPVEELDVMFSELVDELDLTDKHREAMFALPAEKKWQI 85

  Fly   117 ICDQEMVQAKDP-----PSHYLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLE 176
            .|.::..|.::.     |..|:.:|.:    .|:|...|.|     :|.:   |...::.:..|:
Mouse    86 YCSKKKDQEENKGATSWPEFYIDQLNS----MAARKSLLAL-----EKEE---EEERSKTIESLK 138

  Fly   177 ISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIV 241
            .:|||..:.:|..|:|     ||.|...|:| |:.|.:|
Mouse   139 TALRTKPMRFVTRFID-----LDGLSCILNF-LKTMDYE-------------------------- 171

  Fly   242 MGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIA 306
                                         |.:||
Mouse   172 -----------------------------TSESR------------------------------- 176

  Fly   307 KLNMGAATDDIHVSIM-CLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAIC 370
                      ||.|:: |::|:|||..|...|:.|.|:||.||.||..::::||..|||:|.|:|
Mouse   177 ----------IHTSLIGCIKALMNNSQGRAHVLAHSESINVIAQSLSTENIKTKVAVLEILGAVC 231

  Fly   371 LVKGGHEIILGSFDNFKDVCQEKRRFQTL---MEYFMNFEAFNIDFMVACMQFMNIVVH---SVE 429
            ||.|||:.:|.:..:::....|:.|||||   ::.........:....|.|.|:|.|:.   .||
Mouse   232 LVPGGHKKVLQAMLHYQKYASERTRFQTLINDLDKSTGRYRDEVSLKTAIMSFINAVLSQGAGVE 296

  Fly   430 DMNYRVHLQYEFTALG---------------LDKYLE---------------------------- 451
            .:::|:||:|||..||               ||::|:
Mouse   297 SLDFRLHLRYEFLMLGIQPVIDKLREHENSTLDRHLDFFEMLRNEDELEFAKRFELVHIDTKSAT 361

  Fly   452 ------RIRLTESEEL--------------------KVQISAYLDNVFDVAALMED--SETKTSA 488
                  |.|||.||..                    .||....||.:.....:..|  .:..::.
Mouse   362 QMFELTRRRLTHSEAYPHFMSILHHCLQMPYKRSGNTVQYWLLLDRIIQQIVIQNDKGQDPDSTP 426

  Fly   489 LE---------------RVQELEDQLEREIDRNSEFLYKYAELESESLTLKTEREQ----LAMIR 534
            ||               .|::.::|.|:....::|...|..:.|.|......|:|:    |..::
Mouse   427 LENFNIKNVVRMLVNENEVKQWKEQAEKMRKEHNELQQKLEKKERECDAKTQEKEEMMQTLNKMK 491

  Fly   535 QKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSG 599
            :|||:|.|      :|.:.:.:..|.......:..:.:..::|...|.|    |.||..  .:||
Mouse   492 EKLEKETT------EHKQVKQQVADLTAQLHELNRRAVCAAVPGGPSPG----APGGPF--PSSG 544

  Fly   600 AASLTLPPPPPPMPASPTASSAAPPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPML 664
            ..|| |||||||:     .|..|.||||||.||..||||
Mouse   545 LGSL-LPPPPPPL-----LSGGALPPPPPPLPPGGPPPP-------------------------- 577

  Fly   665 SSFQPPPPPVAGFMPAPDG--AMTIKRK---VPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIF 724
                |.|||:.|.:|.|..  ::|:|:|   .||. .|.:.||..|..|::.||::.|:||.|:|
Mouse   578 ----PGPPPLGGVLPPPGAPVSLTLKKKNIPQPTN-ALKSFNWSKLPENKLDGTVWTEIDDTKVF 637

  Fly   725 KQIDFNEFEERFKIGIGGALR-------NGSNGTE---VDGSLQSSKRFKRPDNVSLLEHTRLRN 779
            |.:|..:.|..|     .|.:       |.|...|   :|.:|.|..:.|   .:|:::..|.:|
Mouse   638 KILDLEDLERTF-----SAYQRQQEFFVNNSKQKEADAIDDTLSSKLKVK---ELSVIDGRRAQN 694

  Fly   780 IAISRRKLGMPIDDVIAAIHSLDLKK-LSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEE 843
            ..|...:|.:..|::..||.::|.:: |..:.:|.|.|.||..:::...:|:   :.:...:.:.
Mouse   695 CNILLSRLKLSNDEIKRAILTMDEQEDLPKDMLEQLLKFVPEKSDIDLLEEH---KHELDRMAKA 756

  Fly   844 DKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGN 908
            |:|:.::||:.....:|..:.:...|.:.|..:.|:|::|...|..:.:||..|.:||:||||||
Mouse   757 DRFLFEMSRINHYQQRLQSLYFKKKFAERVAEVKPKVEAIRSGSEEVFRSRALKQLLEVVLAFGN 821

  Fly   909 YLNSNKRGPAYGFKLQSLDTLIDTKST-DKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASV 972
            |:|..:||.|||||:.||:.:.||||: ||..:||||::..:..|:|::||...||....:||.|
Mouse   822 YMNKGQRGNAYGFKISSLNKIADTKSSIDKNITLLHYLITIVENKYPKVLNLSEELRDIPQAAKV 886

  Fly   973 ALENVVADVQELEKGMDLVRKEAELRVKGAQ--------THILRDFLNNSEDKLKKIKSDLRHAQ 1029
            .:..:..::..|..|:..|  |.||..:.:|        ..::..|:..:......::..|..|:
Mouse   887 NMTELDKEISTLRSGLKAV--ETELEYQKSQPPQPGDKFVSVVSQFITLASFSFSDVEDLLAEAK 949

  Fly  1030 EAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMR 1094
            |.|.:.|::||:.:.......||.:..:|.:                   |:|.:|:||:.:..|
Mouse   950 ELFTKAVKHFGEEAGKIQPDEFFGIFDQFLQ-------------------AVAEAKQENENMRKR 995

  Fly  1095 NKVNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKS-EPYRRA 1158
            .:..:::.:|         ||.:.|.:.:...||:.|...::   :|..:|::..|:| |.:.:.
Mouse   996 KEEEERRARL---------EAQLKEQRERERKVRKAKESSEE---SGEFDDLVSALRSGEVFDKD 1048

  Fly  1159 DAVRRSQRRRIDN 1171
            .:..:..|:||.|
Mouse  1049 LSKLKRNRKRISN 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	67/299 (22%)
		Drf_FH3	374..567	CDD:283917	58/288 (20%)
		FH2	687..1063	CDD:280362	114/398 (29%)
Daam1	NP_080378.2	Drf_GBD	45..232	CDD:399398	68/306 (22%)
		Drf_FH3	235..439	CDD:368862	41/203 (20%)
		PRK12704	444..>513	CDD:237177	17/74 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	457..478		4/20 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	526..596		38/111 (34%)
		FH2	600..982	CDD:396655	113/414 (27%)
		Actin-binding. /evidence=ECO:0000250	693..702		2/8 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1007..1033		6/28 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1056..1077		4/6 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54599
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950