Protein Alignment Frl and daam-1

DIOPT Version :9

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_503132.3
• Gene: daam-1 / 186392
• WormBaseID: WBGene00018976
• Length: 987
• Species: Caenorhabditis elegans
• Alignment Length: 1156
• Identity: 266/1156 - (23%)
• Similarity: 465/1156 - (40%)
• Gaps: 280/1156 - (24%)

  Fly    63 QHVRQPSLRSRSQQPMPTTD-ELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAK 126
            |||....:.:    |.|... ::|:.|..::..:.|..:|.:.:.||..|||..::..|..:|.:
 Worm    27 QHVHDDVIFA----PAPLDPAKIDKDFECLVKELGLNEEKQQEMHNYSMEKKMSLLVSQHCLQTE 87

  Fly   127 DPPSHYLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFL 191
            | .||::..|:..                   ::..|.:|.:.:.|::|.|||||.:..:::.|:
 Worm    88 D-ASHFIGFLKNL-------------------QQSFVIDSNTIRQLQELVISLRTQNYSYLESFI 132

  Fly   192 DDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGL 256
              ::.||..|.:.|:
 Worm   133 --SSSGLKLLTELLN-------------------------------------------------- 145

  Fly   257 LSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSI 321
                            ...||:|             |:.|:|                    ..:
 Worm   146 ----------------QCHQQYT-------------LEQPAL--------------------FFL 161

  Fly   322 MCLRAIMNNKYGFNMVI---QHREAINCIALSLIHKSLRTKALVLELLAAICLVKG-GHEIILGS 382
            ..|||::|:..|...|:   ||  .:..||.::..:..:.|.:.:|:|:.:|.:.. ||..:|.:
 Worm   162 YALRALLNSPNGRVAVLNDEQH--VLVSIARAVDFRDFKCKIVAIEILSGLCFIPDEGHIQVLRA 224

  Fly   383 FDNFKDVCQEKRRFQTLMEYFMNFEAFNID---FMVACMQFMNIVVHSVEDMN---YRVHLQYEF 441
            ......:..|:.|||||:.......:.:.|   ...|....:|.::.:....|   ||.||:.|.
 Worm   225 ITEVSTLLGERTRFQTLVSDLHRTYSTDRDTDRVRTAIFGLINALLRTGAAENCAIYRQHLRSEL 289

  Fly   442 TALGLDKYLERIRLTESEELKVQISAY----LDNVFDVAALMEDSETKTSA-------LERVQEL 495
            ..||:...||:.|...|:.|:..|..:    .::...:|.....|:...|:       .|.|..:
 Worm   290 LMLGMSTTLEQCREGASQRLEDHIDLFEMMRKEDEISLAGSCTSSDISMSSETSSPIDFESVVGM 354

  Fly   496 EDQLEREIDRNSEF---------------------LYKYAELESESLTLKTEREQLAMIRQKLEE 539
            .:.|..:::.:...                     |::..:|..:.|||:|....:..:...|:.
 Worm   355 AEALHIKLNHSQALPHFHSLLQHLFMVPSDDQHVPLWRLFDLILQHLTLQTTVNGMTDVNSPLQN 419

  Fly   540 EL---TVMQRMLQH-------NEQELKKRD-TLLHTKNMELQTLSRSLPRSASSGDGSLANGGLM 593
            .:   .::.|:..|       .|.|..|.| .|..|:.|||:.      |.|...||. |...:.
 Worm   420 HVDMSEILARLQNHCDYERIAKELEKAKEDMDLERTRIMELEN------RLADFSDGR-AGSRIS 477

  Fly   594 AGSTSGAASLTLPPPPPPMPASPTASSAAPPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPP 658
            ..|||.::|     |..|.|        :||..||..||||||||      .|.|.|.|
 Worm   478 LASTSASSS-----PSDPCP--------SPPLLPPVCPPAPPPPP------PPIGGLTS------ 517

  Fly   659 HAPPMLSSFQPPPPPVAGFMPAPDGAMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKI 723
                       ||......:|.|.|.|            .||||..|..::.|||:::.:|||||
 Worm   518 -----------PPKDALKNVPEPPGNM------------KTLNWQRLTLDKTRGTVWDGIDDEKI 559

  Fly   724 FKQIDFNEFEERFKIGIGGALRNGSNGTEVDGSLQSSKRFKRPD--NVSLLEHTRLRNIAISRRK 786
            :||:|..|        :.|.....|:..:.|.........:||.  |:::::..|.:|..|...|
 Worm   560 YKQLDLTE--------LSGCFAASSSHKDEDTDTLYGTINRRPQQANITVIDPRRYQNCTIMLSK 616

  Fly   787 LGMPIDDVIAAIHSLDLK-KLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQL 850
            |.:...::..|:.|:|.| ||..:.:|.:.|.:||..|:....|.:.:.....:|...|::|.::
 Worm   617 LKLSHKEIKQAMMSMDEKCKLPKDMIEQMLKFMPTKEELTQINESVQKHGSPTVLALADRYMYEI 681

  Fly   851 SRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKR 915
            |.:.|...:|..:|.:.:|.|.|..:.|.:|.:..|::|.:|:::|:.:|.|:||.|||||..||
 Worm   682 SSIPRFEQRLRCLNIIRSFHDRVEALVPFIQVVLKATSSCQQNKRFRQILTIILAIGNYLNFGKR 746

  Fly   916 -GPAYGFKLQSLDTLIDTKSTDKRS-SLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVV 978
             |.||||::.|::.|.|.|:..:.. :|||::|..|..|:|:|..|:.:.....:||..:.....
 Worm   747 NGNAYGFEMASINKLADVKNALRNDRNLLHFLVNFIEKKYPDLTKFKKDFATVTEAARFSQSETA 811

  Fly   979 ADVQELEKGMDLVRKEAELRVKGAQTH--------------ILRDFLNNSEDKLKKIKSDLRHAQ 1029
            |:::.||:.:.:||||..|.....:..              :.:.|:..:..:...:....|..:
 Worm   812 AEIRNLEEALLIVRKELNLLESTTKVELPEHIPPENDRFALVAKAFIEKATAEYHNLDKMFREMK 876

  Fly  1030 EAFKECVEYF--GDSSRNADAAAFFALIVRFTRAFKQHDQ------ENEQRLRLEKAAALAASKK 1086
            ..|.:|.:||  ..|........||::|.:|...|.::.|      |.|::::.:..|....:||
 Worm   877 NKFSDCAKYFCYSPSGGVPVPEEFFSVINKFLNTFNEYHQQLWAEVEEEEKIKRQTIARSFLAKK 941

  Fly  1087 ENDQVLMRNKVNQKK---QQLPSNGALSLQEAVINELKSKAHSVREKKLLQ 1134
            ..    .|.|.|.|:   :||.|  ||...:....||.....|.|.||.::
 Worm   942 ST----TRRKENHKERDFEQLIS--ALQSGDIFKEELSRLRTSFRPKKTVK 986

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	50/297 (17%)
		Drf_FH3	374..567	CDD:283917	47/242 (19%)
		FH2	687..1063	CDD:280362	106/396 (27%)
daam-1	NP_503132.3	Drf_GBD	39..212	CDD:368864	49/295 (17%)
		Drf_FH3	216..408	CDD:368862	38/191 (20%)
		FH2	524..973	CDD:214697	127/474 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54599
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3069
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.950