Protein Alignment Frl and cyk-1

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_741211.3
• Gene: cyk-1 / 175983
• WormBaseID: WBGene00000872
• Length: 1437
• Species: Caenorhabditis elegans
• Alignment Length: 1412
• Identity: 287/1412 - (20%)
• Similarity: 504/1412 - (35%)
• Gaps: 440/1412 - (31%)

  Fly    27 AHHHSM----------RNGHQHNGSISSG------------TLQKQDL---------RYDIGCSS 60
            |..|||          |:....:|:..||            ..|:|.|         ..|.|..:
 Worm   112 AERHSMLAGAADFASRRSPFHLSGANGSGRWTDLFSSSRFKRKQRQKLNNVPSSSYSNNDYGTYA 176

  Fly    61 QYQHVRQPSLRSRSQQP----MPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQE 121
            ..|.:...|:.|.|...    ..|.||:...|.|::....| |:..|::.|
 Worm   177 GTQSIGGFSIASNSSGESFALSGTEDEIREEFRKIMLDKGL-PEADKIISN-------------- 226

  Fly   122 MVQAKDPPSHYLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGESTSTQ-----------VLRDL 175
                            |.||                 :.||:.|::..|           |:|.|
 Worm   227 ----------------TPLD-----------------QMKMMIENSRKQDNQAKGRSPEWVVRVL 258

  Fly   176 EISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNL--TNGGDGG 238
            ...|:|.:|...|:             |.::.|:|::.     |||...::..:.:  .:|..|.
 Worm   259 GEILKTKNIPECKQ-------------DIVTVRVQLVG-----QGVSFLNKFAVEVHDESGRTGA 305

  Fly   239 EIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKR-RS 302
            :::.                                                 .|.|..||| ||
 Worm   306 DLIC-------------------------------------------------CLYSLVLKRLRS 321

  Fly   303 RHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVIQHREAINCIALSLI----------HKSLR 357
            ..:.........|.:...:.|:|.::|...|..:|::....:..:.:..:          |::..
 Worm   322 SEVGSKYELDLIDFLQEIVRCVRTLINTHVGLVLVLRRNSPVYSLLIQTLCVLNRREQNDHEAAE 386

  Fly   358 TKALVLELL-AAICLVKGGHEII------LGSFDNFKDV-----CQEKR------RFQTLMEYFM 404
            .:|:.:::: ....|:...|:.:      .|....|.::     .:.||      ||:.|:..
 Worm   387 IRAIRVDVVRTCYTLIFVQHDTLSTPIEMTGQQKMFMELSLIAKAESKRLNEPVSRFRPLISC-- 449

  Fly   405 NFEAFNIDFM--------VACMQFMNIVVHSVEDMNY--------------RVHLQYEFTALGLD 447
                  |||:        :..:..:|::::.| |.|.              |:.|:.|.....|.
 Worm   450 ------IDFLESRDPKQGMYVLLMINMMINGV-DRNISDDQMWTEETMWQARMRLRSEAAKDKLH 507

  Fly   448 KYLERIRLTESEELKVQI--------------------------SAY--LDNVFDVAA------- 477
            ||:|  :.|.||.:..||                          ..|  ||..|::.|
 Worm   508 KYIE--KFTTSETVNSQIRDVAQNMLTEHNADLETLMGKLENVKGEYDTLDGCFELLAANSEATG 570

  Fly   478 ----------LM----EDSETKTSALERVQ-ELEDQL--EREIDRNSEFLYKYAELESESLTLKT 525
                      ||    ||..||.|.::.:: .:.|.|  ...||..:::.:.:....:|.:....
 Worm   571 TETVLLSILQLMTLTNEDMSTKRSYMKLIETAISDILLHRTPIDPQADYKFVFEVPVAEIIDKMQ 635

  Fly   526 EREQLAMIRQ--KLEEELTVMQRM-------LQHNEQELKKRDTLLHTKNMELQTLSRSLPRSAS 581
            :.|....:||  ..::|...||..       .|...:||:|     |..:.::     .||....
 Worm   636 DEEMAKKVRQATSAKQEAVAMQGEYWKTLCDFQKEAEELRK-----HINDPKI-----PLPPPTK 690

  Fly   582 SGDGSLANGGLMAGSTSGAASLTLPP----PPPPMPASPTASSAAPPPPPP-------PAPPAPP 635
            .        .|.|.|||...|..|||    |||| |..|..:...||||||       ..||.||
 Worm   691 M--------NLSAPSTSAGGSSALPPITGGPPPP-PGLPPITGGPPPPPPPGGLPPITGGPPPPP 746

  Fly   636 PPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFM-----PAPDG-----AMTIKRK 690
            ||.|..|:        |..|.||..||......|||||..||.     |.|.|     |..|...
 Worm   747 PPGGLPPI--------SGGPPPPPPPPGGCPPPPPPPPPGGFKGGPPPPPPPGMFAPMAPVIPDY 803

  Fly   691 VPTKYKLPTLN-------WIA--LKPNQVR------GTIFNELDDEKIFKQIDFNEFEERFKIGI 740
            :|.| |:|.::       |.|  :.|..:.      ||...:|..:::|.::       |.|...
 Worm   804 LPPK-KVPKVDGPMRKFPWGAHTINPRDIPRESFWVGTNEEQLTSDRMFDRL-------RTKFAT 860

  Fly   741 GGALRNGSNGTEVDGSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKK 805
            ..|..:|:.|    |.|.|.|:.|....:.  :...|:.:.|.:..:.|...::..||..::.|.
 Worm   861 KPAANSGTLG----GVLNSKKKVKTAQVIH--DDKLLQKLGILQGSIKMSHSELKLAILEVNEKV 919

  Fly   806 LSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFV 870
            |::..:|.|:..:|.:.|:.. |...:.:...:.:.|.::|:.:|.:::.:..:|.::.:...|.
 Worm   920 LTVGFLEQLRSAMPVEKELID-KLRAVNKAQFEEMPEGEQFVTRLLQIQGLPLRLDLVLFKMRFS 983

  Fly   871 DSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLN--SNKRGPAYGFKLQSLDTLIDTK 933
            :.::.:.|.:.|:..|...::.|..|:..|::|||.||::.  :.....||.|.::.|..|:|||
 Worm   984 EVLNELKPAMSSVMEACEEVRASEGFRTFLKLVLATGNFMGGATKNYSSAYAFDMRMLTRLVDTK 1048

  Fly   934 STDKRSSLLHYIVATI------RAKFPELLNF----ESELYGTDKAASVA--LENVVADVQELEK 986
            ..|.|.:|||:::..:      ||:| .|.:|    ||.....|:.....  .||   ::::||.
 Worm  1049 DVDNRHTLLHHLIEEMKRIDPRRARF-ALTDFHHCIESSRVNADEIRKTVQLTEN---NIKKLEN 1109

  Fly   987 GMDLVRKEAELRVKGAQTHILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAF 1051
            .:.:.:.:.|   :......:|.|...:..:...:.|.....:..::..|:|:..:.:......|
 Worm  1110 CLKVYKIQGE---RDLFDEKMRPFHEKAVKEFSTVSSMCGKMKNDWESLVKYYAFNDKKYPMEEF 1171

  Fly  1052 FALI----VRFTRAFKQHDQE-----NEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSN 1107
            ||.|    .:::.|:|:.|.|     .|.....:|...|..|::|...:..|..:|    ::|..
 Worm  1172 FADIRTFSEQYSNAWKELDAEAEAKRKEAEFETQKRKQLQQSQQERKPLQERQAIN----RVPRT 1232

  Fly  1108 GALSL-------QEAVINELK-------------SKAHSVREKKLL----------------QQD 1136
            .|..:       :..|::||:             |..:|...:..|                |:.
 Worm  1233 PAAMIRVSTAADKAGVLDELERATGNADFLQTLMSATNSRTPRSGLPARTRGGGRLGGGLDRQRS 1297

  Fly  1137 EVYN--GALEDILLGLKSEPYRRADAVRRSQRRRIDNNRLSRTLEEM 1181
            ...|  |.|:| |.|..|||.......|   .|.:..|.|.|...|:
 Worm  1298 RHQNALGQLQD-LTGCASEPVLSGQFAR---SRNVPQNDLQRQNMEL 1340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	46/322 (14%)
		Drf_FH3	374..567	CDD:461885	55/292 (19%)
		FH2	687..1063	CDD:396655	86/408 (21%)
cyk-1	NP_741211.3	Drf_GBD	201..387	CDD:461886	44/300 (15%)
		Drf_FH3	422..630	CDD:461885	41/218 (19%)
		FH2	807..1257	CDD:214697	99/475 (21%)