Protein Alignment Frl and frl-1

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_497505.4
• Gene: frl-1 / 175346
• WormBaseID: WBGene00021698
• Length: 1200
• Species: Caenorhabditis elegans
• Alignment Length: 1204
• Identity: 414/1204 - (34%)
• Similarity: 614/1204 - (50%)
• Gaps: 168/1204 - (13%)

  Fly    30 HSMRNGHQHNGSIS----SGTLQKQDLRYDIGCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAK 90
            :|:|..:..:..|.    |..:|.::      ||:.   :..|::    ..|||..::||:.|..
 Worm    57 NSLRRSNSTSSDIRSRRISSVIQSRE------CSTM---IVGPTV----APPMPPQEQLDKMFDD 108

  Fly    91 VLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHYLSKLRTYLDPKASRSHRLYLFYF 155
            ||..||||.||.::||.||::|||.:|.||::.:...||:.||.||..:||.|..:.
 Worm   109 VLKHMDLPVDKLRILRGYDNDKKWKLIVDQQVAKQVTPPAKYLEKLSYFLDKKLLKK-------- 165

  Fly   156 LCQKRKMVG-ESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQ 219
             ..|.|.:| :.|||.|||.:|||||||.::||.|||:..|.||..||||:...|
 Worm   166 -ALKNKEIGVDETSTSVLRHIEISLRTNSVDWVFEFLNTPNLGLRKLVDYMRTLL---------- 219

  Fly   220 GVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSH--GNSTGHGLANGTLDSRQQHTMSY 282
             ..||.                  :..|.|.|...|.|:.  .:|.|....:.:|:....|..||
 Worm   220 -ADCAP------------------SVPSTSSGLPAGFLNSTANSSVGANNNHSSLNESPSHNSSY 265

  Fly   283 GFLRPTIADALDS-----PSLKRRSRHIAK----LNMGAATDDIHVSIMCLRAIMNNKYGFNMVI 338
            .....|.|:..:|     ..||:....|:|    ...|.|.||||:.:||||||||||.||..|.
 Worm   266 EMSTTTTANTSNSFDATANLLKKGPLTISKGKVAKTTGEAVDDIHICMMCLRAIMNNKQGFQQVF 330

  Fly   339 QHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDVCQEKRRFQTLMEYF 403
            ...:||.||..|::|::||||.|||::|::||.|:||.|::..:||.|:...:|.|||.|||::.
 Worm   331 ADTDAIYCIVRSILHQNLRTKTLVLQMLSSICWVQGGQELVSDAFDRFEKDFREPRRFWTLMQFV 395

  Fly   404 MNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQISAY 468
            .:...|:::|:.:.:||....| :|:|:|:|||||||.|.||||||::.:...||:||:.::.:|
 Worm   396 SHPPEFHVEFLSSAVQFFYYFV-NVDDLNFRVHLQYEMTLLGLDKYIDMMAECESDELQERMISY 459

  Fly   469 LDNVFDVAALMEDSETKTSALERVQELEDQLEREIDRNSEFLYKY----AELESESLTLKTEREQ 529
            .:|..||..|::||..||..|:..:.:..||.:..:|..|...|:    |.|:.....|..|||
 Worm   460 QNNGIDVQQLLDDSNQKTELLDENERILSQLSQAKERIQEVEAKWITDKAALDRRLFDLVKERE- 523

  Fly   530 LAMIRQKLEEELTVMQRMLQHNEQ--ELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGL 592
             :|.::.:||:.:..:.|.:.:.|  |.:||   |..|..||:.:.:.:...........|  ..
 Worm   524 -SMEKEYVEEKGSWTKTMNEKDRQAREERKR---LEQKIGELEAIQKQMQAGLQVQQQQQA--AA 582

  Fly   593 MAGSTSGAASLTLPPPP---------------PPMPASPTASSAAPPPP------------PPPA 630
            .|.:.:...|...||||               ||.||.|..||..||||            |.|.
 Worm   583 AAAAAAAQKSPPTPPPPAPGPHKEQRRSTSKDPPRPAPPPVSSIPPPPPIAGLLAANGTNVPIPP 647

  Fly   631 PPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFM-PAPDGAMTIKRKVPTK 694
            ||.||.|...|  |:|        |.||..||||....|||||..|.| ||.:.|.|||:...||
 Worm   648 PPPPPLPQNLS--GAP--------PPPPPPPPMLGGPPPPPPPPGGLMGPASNDAKTIKKIYQTK 702

  Fly   695 YKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKI--------------GIGGALR 745
            .|||.|||.|:||.|.:.|:|.:|:||.|.:::||::.||.||:              .:.|.:.
 Worm   703 NKLPQLNWTAMKPMQAKNTVFEKLNDELIIEKLDFSKLEEMFKLAQPTLGLAEPKSEQSVIGQVS 767

  Fly   746 NGSNGTEVDGSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLEN 810
            .||. |...|:..:.|.       :||:..||:|:||:|||:.|....::||:|.|:|..||.|.
 Worm   768 PGST-TSAAGTSSARKN-------TLLDTKRLQNVAITRRKVAMDAKSIMAAVHQLNLSALSAEK 824

  Fly   811 VELLQKMVPTDAEVKSY--KEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSV 873
            |::|.:::|||.|.|.|  |:........:.|:|:|.|:..|..:||:..|||:|..|..|.:|.
 Worm   825 VDILSRILPTDEERKLYAGKKTTESENSMENLSEDDNFVAALCEIERLEHKLAVMRVMSEFDESA 889

  Fly   874 HLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKS-TDK 937
            .|:.||...:..||...::::.|..|||::||||||:||.|||.||||||.|||:|...|: .|:
 Worm   890 GLLEPQFTHVTAASKCAREAQLFHGVLEVILAFGNYMNSGKRGGAYGFKLSSLDSLAILKAPADR 954

  Fly   938 RSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGA 1002
            ..:|||.|||.|....|.|..|..:|...|||.||..::|..|::||..|..:..||.||  ||.
 Worm   955 SLTLLHMIVAEIEKNLPHLKTFSEQLKFVDKATSVQWDSVQTDMKELAAGFKMAEKEQEL--KGT 1017

  Fly  1003 Q-THILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHD 1066
            . ...|..|..:.:.|:..::...:.|..:||:|.|::|::.::.....||..:..|.
 Worm  1018 DCPEALSTFTASRKQKMADLEQAFQLAASSFKDCCEFYGENEKSTSPTVFFQKLAHFV------- 1075

  Fly  1067 QENEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINELKSKAHSV---- 1127
             :|.|:.|.|..|..|..|:..::...|.:|...|     :.|.|.|:.::.||..|...:
 Worm  1076 -QNYQKCRGENEAKAALEKRRQEEAERRARVASTK-----SSASSEQDQLMMELAEKVGGMGIGK 1134

  Fly  1128 REKKLLQQDEVYNGALEDILLGLK----SEPYRR 1157
            |.:..:....:.:|..|.::.|||    :.|.||
 Worm  1135 RPRGKIDSTRMDHGDFEKLMNGLKHTGGTTPNRR 1168

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	116/305 (38%)
		Drf_FH3	374..567	CDD:461885	70/198 (35%)
		FH2	687..1063	CDD:396655	145/393 (37%)
frl-1	NP_497505.4	Drf_GBD	94..362	CDD:461886	115/305 (38%)
		Drf_FH3	366..561	CDD:461885	70/200 (35%)
		FH2	695..1079	CDD:396655	146/401 (36%)