DRSC/TRiP Functional Genomics Resources

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Protein Alignment Frl and frl-1

DIOPT Version :9

Sequence 1:NP_729954.2 Gene:Frl / 39561 FlyBaseID:FBgn0267795 Length:1183 Species:Drosophila melanogaster
Sequence 2:NP_497505.4 Gene:frl-1 / 175346 WormBaseID:WBGene00021698 Length:1200 Species:Caenorhabditis elegans


Alignment Length:1204 Identity:414/1204 - (34%)
Similarity:614/1204 - (50%) Gaps:168/1204 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 HSMRNGHQHNGSIS----SGTLQKQDLRYDIGCSSQYQHVRQPSLRSRSQQPMPTTDELDRRFAK 90
            :|:|..:..:..|.    |..:|.::      ||:.   :..|::    ..|||..::||:.|..
 Worm    57 NSLRRSNSTSSDIRSRRISSVIQSRE------CSTM---IVGPTV----APPMPPQEQLDKMFDD 108

  Fly    91 VLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHYLSKLRTYLDPKASRSHRLYLFYF 155
            ||..||||.||.::||.||::|||.:|.||::.:...||:.||.||..:||.|..:.        
 Worm   109 VLKHMDLPVDKLRILRGYDNDKKWKLIVDQQVAKQVTPPAKYLEKLSYFLDKKLLKK-------- 165

  Fly   156 LCQKRKMVG-ESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQ 219
             ..|.|.:| :.|||.|||.:|||||||.::||.|||:..|.||..||||:...|          
 Worm   166 -ALKNKEIGVDETSTSVLRHIEISLRTNSVDWVFEFLNTPNLGLRKLVDYMRTLL---------- 219

  Fly   220 GVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSH--GNSTGHGLANGTLDSRQQHTMSY 282
             ..||.                  :..|.|.|...|.|:.  .:|.|....:.:|:....|..||
 Worm   220 -ADCAP------------------SVPSTSSGLPAGFLNSTANSSVGANNNHSSLNESPSHNSSY 265

  Fly   283 GFLRPTIADALDS-----PSLKRRSRHIAK----LNMGAATDDIHVSIMCLRAIMNNKYGFNMVI 338
            .....|.|:..:|     ..||:....|:|    ...|.|.||||:.:||||||||||.||..|.
 Worm   266 EMSTTTTANTSNSFDATANLLKKGPLTISKGKVAKTTGEAVDDIHICMMCLRAIMNNKQGFQQVF 330

  Fly   339 QHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDVCQEKRRFQTLMEYF 403
            ...:||.||..|::|::||||.|||::|::||.|:||.|::..:||.|:...:|.|||.|||::.
 Worm   331 ADTDAIYCIVRSILHQNLRTKTLVLQMLSSICWVQGGQELVSDAFDRFEKDFREPRRFWTLMQFV 395

  Fly   404 MNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQISAY 468
            .:...|:::|:.:.:||....| :|:|:|:|||||||.|.||||||::.:...||:||:.::.:|
 Worm   396 SHPPEFHVEFLSSAVQFFYYFV-NVDDLNFRVHLQYEMTLLGLDKYIDMMAECESDELQERMISY 459

  Fly   469 LDNVFDVAALMEDSETKTSALERVQELEDQLEREIDRNSEFLYKY----AELESESLTLKTEREQ 529
            .:|..||..|::||..||..|:..:.:..||.:..:|..|...|:    |.|:.....|..||| 
 Worm   460 QNNGIDVQQLLDDSNQKTELLDENERILSQLSQAKERIQEVEAKWITDKAALDRRLFDLVKERE- 523

  Fly   530 LAMIRQKLEEELTVMQRMLQHNEQ--ELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGL 592
             :|.::.:||:.:..:.|.:.:.|  |.:||   |..|..||:.:.:.:...........|  ..
 Worm   524 -SMEKEYVEEKGSWTKTMNEKDRQAREERKR---LEQKIGELEAIQKQMQAGLQVQQQQQA--AA 582

  Fly   593 MAGSTSGAASLTLPPPP---------------PPMPASPTASSAAPPPP------------PPPA 630
            .|.:.:...|...||||               ||.||.|..||..||||            |.|.
 Worm   583 AAAAAAAQKSPPTPPPPAPGPHKEQRRSTSKDPPRPAPPPVSSIPPPPPIAGLLAANGTNVPIPP 647

  Fly   631 PPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFM-PAPDGAMTIKRKVPTK 694
            ||.||.|...|  |:|        |.||..||||....|||||..|.| ||.:.|.|||:...||
 Worm   648 PPPPPLPQNLS--GAP--------PPPPPPPPMLGGPPPPPPPPGGLMGPASNDAKTIKKIYQTK 702

  Fly   695 YKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKI--------------GIGGALR 745
            .|||.|||.|:||.|.:.|:|.:|:||.|.:::||::.||.||:              .:.|.:.
 Worm   703 NKLPQLNWTAMKPMQAKNTVFEKLNDELIIEKLDFSKLEEMFKLAQPTLGLAEPKSEQSVIGQVS 767

  Fly   746 NGSNGTEVDGSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLEN 810
            .||. |...|:..:.|.       :||:..||:|:||:|||:.|....::||:|.|:|..||.|.
 Worm   768 PGST-TSAAGTSSARKN-------TLLDTKRLQNVAITRRKVAMDAKSIMAAVHQLNLSALSAEK 824

  Fly   811 VELLQKMVPTDAEVKSY--KEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSV 873
            |::|.:::|||.|.|.|  |:........:.|:|:|.|:..|..:||:..|||:|..|..|.:|.
 Worm   825 VDILSRILPTDEERKLYAGKKTTESENSMENLSEDDNFVAALCEIERLEHKLAVMRVMSEFDESA 889

  Fly   874 HLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKS-TDK 937
            .|:.||...:..||...::::.|..|||::||||||:||.|||.||||||.|||:|...|: .|:
 Worm   890 GLLEPQFTHVTAASKCAREAQLFHGVLEVILAFGNYMNSGKRGGAYGFKLSSLDSLAILKAPADR 954

  Fly   938 RSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGA 1002
            ..:|||.|||.|....|.|..|..:|...|||.||..::|..|::||..|..:..||.||  ||.
 Worm   955 SLTLLHMIVAEIEKNLPHLKTFSEQLKFVDKATSVQWDSVQTDMKELAAGFKMAEKEQEL--KGT 1017

  Fly  1003 Q-THILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHD 1066
            . ...|..|..:.:.|:..::...:.|..:||:|.|::|::.::.....||..:..|.       
 Worm  1018 DCPEALSTFTASRKQKMADLEQAFQLAASSFKDCCEFYGENEKSTSPTVFFQKLAHFV------- 1075

  Fly  1067 QENEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINELKSKAHSV---- 1127
             :|.|:.|.|..|..|..|:..::...|.:|...|     :.|.|.|:.::.||..|...:    
 Worm  1076 -QNYQKCRGENEAKAALEKRRQEEAERRARVASTK-----SSASSEQDQLMMELAEKVGGMGIGK 1134

  Fly  1128 REKKLLQQDEVYNGALEDILLGLK----SEPYRR 1157
            |.:..:....:.:|..|.::.|||    :.|.||
 Worm  1135 RPRGKIDSTRMDHGDFEKLMNGLKHTGGTTPNRR 1168

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FrlNP_729954.2 Drf_GBD 77..371 CDD:283920 116/305 (38%)
Drf_FH3 374..567 CDD:283917 70/198 (35%)
FH2 687..1063 CDD:280362 145/393 (37%)
frl-1NP_497505.4 Drf_GBD 95..362 CDD:399398 115/304 (38%)
Drf_FH3 366..561 CDD:368862 70/200 (35%)
FH2 695..1079 CDD:396655 146/401 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160166946
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG1923
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S3972
OMA 1 1.010 - - QHG54599
OrthoDB 1 1.010 - - D149905at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_103315
Panther 1 1.100 - - O PTHR45857
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3069
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1110.700

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