Protein Alignment Frl and DIAPH2

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_006720.1
• Gene: DIAPH2 / 1730
• HGNCID: 2877
• Length: 1101
• Species: Homo sapiens
• Alignment Length: 1208
• Identity: 284/1208 - (23%)
• Similarity: 488/1208 - (40%)
• Gaps: 313/1208 - (25%)

  Fly    67 QPSLRSRSQQPMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSH 131
            ||....||.. :...:.|| .|.|::..|:|..:|...|||.|...|.:|:     ||
Human    91 QPLYDERSLN-LSEKEVLD-LFEKMMEDMNLNEEKKAPLRNKDFTTKREMV-----VQ------- 141

  Fly   132 YLSKLRTYLDPKASRSHRLYLF--YFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDT 194
            |:|........|.|: |...|.  .::.:.|..:.:......|..|.:||.:|.:.||..|   .
Human   142 YISATAKSGGLKNSK-HECTLSSQEYVHELRSGISDEKLLNCLESLRVSLTSNPVSWVNNF---G 202

  Fly   195 NQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSH 259
            ::||..|:|.|                     |:|
Human   203 HEGLGLLLDEL---------------------EKL------------------------------ 216

  Fly   260 GNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCL 324
                        ||.:||                         .:|.|.|.       :..|.||
Human   217 ------------LDKKQQ-------------------------ENIDKKNQ-------YKLIQCL 237

  Fly   325 RAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDV 389
            :|.||||:|...::....::..:|.::..|.......::::|:|||:|  |.|.||.........
Human   238 KAFMNNKFGLQRILGDERSLLLLARAIDPKQPNMMTEIVKILSAICIV--GEENILDKLLGAITT 300

  Fly   390 CQE---KRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLE 451
            ..|   :.||..::|...|.||  :...||||||:|.:|.|..::::|:||:.||...||...|.
Human   301 AAERNNRERFSPIVEGLENQEA--LQLQVACMQFINALVTSPYELDFRIHLRNEFLRSGLKTMLP 363

  Fly   452 RIRLTESEELKVQISAYLDN-----------VFDVAALMED---------SETKTSALER--VQE 494
            .::..|::||.:|:..:.:|           :.|:.|.|:|         :..|.:|.|.  :..
Human   364 DLKEKENDELDIQLKVFDENKEDDLTELSHRLNDIRAEMDDMNEVYHLLYNMLKDTAAENYFLSI 428

  Fly   495 LEDQLEREIDRNSEFL-------------------------YKYAELESESLT-----------L 523
            |:..|   :.||..::                         :||.:.....||           :
Human   429 LQHFL---LIRNDYYIRPQYYKIIEECVSQIVLHCSGMDPDFKYRQRLDIDLTHLIDSCVNKAKV 490

  Fly   524 KTEREQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLA 588
            :...::.|...:|.:||.|..|..    :.||:|||..:.....|:|.| |:..:..||..|
Human   491 EESEQKAAEFSKKFDEEFTARQEA----QAELQKRDEKIKELEAEIQQL-RTQAQVLSSSSG--- 547

  Fly   589 NGGLMAGSTSGAASLTLPPPP--PPMPASPTASSAAPPPPPPPAPP-------APPPPPGFSPLG 644
                            :|.||  ||:|       ...|||||||||       .|||||....:|
Human   548 ----------------IPGPPAAPPLP-------GVGPPPPPPAPPLPGGAPLPPPPPPLPGMMG 589

  Fly   645 SPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPDGAMTI------KRKVPTKYKLPTLNWI 703
            .|          ||..||:|....|||||:.|..|.|..::.:      |:....:..:..:||.
Human   590 IP----------PPPPPPLLFGGPPPPPPLGGVPPPPGISLNLPYGMKQKKMYKPEVSMKRINWS 644

  Fly   704 ALKPNQVRGTIF------NELDDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTEVDGSLQSSKR 762
            .::|.::....|      ::.::..:|.::..| |..:.|:      :..:...|...:..:.|:
Human   645 KIEPTELSENCFWLRVKEDKFENPDLFAKLALN-FATQIKV------QKNAEALEEKKTGPTKKK 702

  Fly   763 FKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSY 827
            .|   .:.:|:....:|::|......||.:|:...|..::...||...::.|.|.:|   |.|..
Human   703 VK---ELRILDPKTAQNLSIFLGSYRMPYEDIRNVILEVNEDMLSEALIQNLVKHLP---EQKIL 761

  Fly   828 KEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQ 892
            .|....:.:...|.|.::|.:.:|.|:.:..:|:.:.:...|.:.::.|.|.:.::..|...||:
Human   762 NELAELKNEYDDLCEPEQFGVVMSSVKMLQPRLSSILFKLTFEEHINNIKPSIIAVTLACEELKK 826

  Fly   893 SRKFKAVLEIVLAFGNYLNSNKR-GPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPEL 956
            |..|..:||:||..|||:||..| ..:.|||:..|..:.||||.|::::|||:|......|:.::
Human   827 SESFNRLLELVLLVGNYMNSGSRNAQSLGFKINFLCKIRDTKSADQKTTLLHFIADICEEKYRDI 891

  Fly   957 LNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHILRD--------FLNN 1013
            |.|..||...:.|:.|:.:.:.:::..:|:  .:|..|.::: |..|.....|        |...
Human   892 LKFPEELEHVESASKVSAQILKSNLASMEQ--QIVHLERDIK-KFPQAENQHDKFVEKMTSFTKT 953

  Fly  1014 SEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLE-- 1076
            :.::.:|:.:...:..:.::...|||...|:......||..:..|...|.:..:||.:|..:|
Human   954 AREQYEKLSTMHNNMMKLYENLGEYFIFDSKTVSIEEFFGDLNNFRTLFLEAVRENNKRREMEEK 1018

  Fly  1077 -KAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDEVYN 1140
             :.|.||..|.|.:: |.|.|   ||:||..          ||:              :.||  .
Human  1019 TRRAKLAKEKAEQEK-LERQK---KKKQLID----------INK--------------EGDE--T 1053

  Fly  1141 GALEDILLGLKSEPYRRADAVRRSQRRRI----DNNRL 1174
            |.::::|..|:|      .|..|.:|:||    ||.|:
Human  1054 GVMDNLLEALQS------GAAFRDRRKRIPRNPDNRRV 1085

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	58/295 (20%)
		Drf_FH3	374..567	CDD:461885	59/253 (23%)
		FH2	687..1063	CDD:396655	86/396 (22%)
DIAPH2	NP_006720.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..44
		Drf_GBD	101..284	CDD:461886	58/294 (20%)
		Drf_FH3	292..480	CDD:461885	44/192 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	536..594		27/93 (29%)
		FH2	628..1002	CDD:396655	86/389 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1010..1048		15/51 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1070..1101		7/16 (44%)