Protein Alignment Frl and DIAPH1

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_005210.3
• Gene: DIAPH1 / 1729
• HGNCID: 2876
• Length: 1272
• Species: Homo sapiens
• Alignment Length: 1289
• Identity: 289/1289 - (22%)
• Similarity: 509/1289 - (39%)
• Gaps: 369/1289 - (28%)

  Fly    88 FAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHYLSKLRTYLDPK-ASRSHRLY 151
            |.::|..|:|..:|.:.||    ||  |:|..:|||      |.||...:..:..| :|:|..:|
Human    96 FEQMLLDMNLNEEKQQPLR----EK--DIIIKREMV------SQYLYTSKAGMSQKESSKSAMMY 148

  Fly   152 LFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQ 216
                :.:.|..:.:......|..|.:||..|.:.||:.|   ..:||.:|:|.|. ||    |::
Human   149 ----IQELRSGLRDMPLLSCLESLRVSLNNNPVSWVQTF---GAEGLASLLDILK-RL----HDE 201

  Fly   217 RLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMS 281
            :        ||                                        ..|:.|||.:|.:
Human   202 K--------EE----------------------------------------TAGSYDSRNKHEI- 217

  Fly   282 YGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVIQHREAINC 346
                                                   |.||:|.||||:|...:::..|.|..
Human   218 ---------------------------------------IRCLKAFMNNKFGIKTMLETEEGILL 243

  Fly   347 IALSLIHKSLRTKALVLELLAAICLV---KGGHEIILGSFDNFKDVCQEKRRFQTLMEYFMNFEA 408
            :..::............:||:|:|::   :..:|.:|.:.....:: .|..|||.|::...:  .
Human   244 LVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEM-DEVERFQPLLDGLKS--G 305

  Fly   409 FNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQISAY----- 468
            ..|...|.|:|.:|.::...|::::|||::.|...|||.:.|:.:|..|:|:::||::.:
Human   306 TTIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQDLREIENEDMRVQLNVFDEQGE 370

  Fly   469 ---------LDN----------VFDVAA-LMEDSETKTSALERVQ---------ELEDQLEREID 504
                     ||:          ||.:.. .::||:.:...|..:|         |...|..:.|:
Human   371 EDSYDLKGRLDDIRMEMDDFNEVFQILLNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIE 435

  Fly   505 R------------NSEFLYKYAELESESL------TLKTEREQ--LAMIRQKLEEELTV------ 543
            .            :.:|..::.::|.|.|      ..|.|:.:  .|.:.:||:.|||.
Human   436 ECISQIVLHKNGADPDFKCRHLQIEIEGLIDQMIDKTKVEKSEAKAAELEKKLDSELTARHELQV 500

  Fly   544 -MQRMLQHNEQELK----KRDTLLHTKNMELQTLSRSLPRSASSGDGSLA------NGGLMAGST 597
             |::|....||:|:    ::|. ||::..::.|..:.|....|...|.:|      .......::
Human   501 EMKKMESDFEQKLQDLQGEKDA-LHSEKQQIATEKQDLEAEVSQLTGEVAKLTKELEDAKKEMAS 564

  Fly   598 SGAASLTLP---------PPPPPMPA----------SPTASSAAPPPPPPPAPPAP--------- 634
            ..||::|:|         ||.||:|.          :|..|:..|||||||.||.|
Human   565 LSAAAITVPPSVPSRAPVPPAPPLPGDSGTIIPPPPAPGDSTTPPPPPPPPPPPPPLPGGVCISS 629

  Fly   635 ----------------------PPPPGF-------SPLGSPSGS-------LASTAPSPPHAPPM 663
                                  ||||..       ||...|.|:       |..:|..||..||:
Human   630 PPSLPGGTAISPPPPLSGDATIPPPPPLPEGVGIPSPSSLPGGTAIPPPPPLPGSARIPPPPPPL 694

  Fly   664 LSS---------------FQPPPPPV---------------AGFMPAPDG--------------- 683
            ..|               ..|||||:               .|..|.|.|
Human   695 PGSAGIPPPPPPLPGEAGMPPPPPPLPGGPGIPPPPPFPGGPGIPPPPPGMGMPPPPPFGFGVPA 759

  Fly   684 ------AMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFE--ERF-KIG 739
                  .:|.|:....:.:|...||..|        :..:|..:..:.::..:.||  |.| |:.
Human   760 APVLPFGLTPKKLYKPEVQLRRPNWSKL--------VAEDLSQDCFWTKVKEDRFENNELFAKLT 816

  Fly   740 IGGALRNGSNGTEVD---GSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMP---IDDVIAAI 798
            :..:.:..::..:.|   |..:.|.:.|:...:.:|:....:|::|......||   |.:||..:
Human   817 LTFSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEV 881

  Fly   799 HSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIM 863
            :...|.:..::|   |.|.:|...::|...|...|..|   |.|.::|.:.:..|.|:..:|..:
Human   882 NEAVLTESMIQN---LIKQMPEPEQLKMLSELKDEYDD---LAESEQFGVVMGTVPRLRPRLNAI 940

  Fly   864 NYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGP-AYGFKLQSLD 927
            .:...|.:.|..|.|::.|:..|...|::|..|..:|||.|..|||:|:..|.. |:||.:..|.
Human   941 LFKLQFSEQVENIKPEIVSVTAACEELRKSESFSNLLEITLLVGNYMNAGSRNAGAFGFNISFLC 1005

  Fly   928 TLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVR 992
            .|.||||||::.:|||::.......:|::|.|..||...:||:.|:.||:..::.:::|.:..|.
Human  1006 KLRDTKSTDQKMTLLHFLAELCENDYPDVLKFPDELAHVEKASRVSAENLQKNLDQMKKQISDVE 1070

  Fly   993 KE-----AELRVKGAQTHILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFF 1052
            ::     |....|......:..|:.:::::..|::....:.:..:||..|||....:......||
Human  1071 RDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGEYFLFDPKKLSVEEFF 1135

  Fly  1053 ALIVRFTRAFKQHDQENEQRLRLE---KAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQE 1114
            ..:..|...|.|..:||::|...|   :.|.||..|.|.:    |.:..||::||....|
Human  1136 MDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKE----RLEKQQKREQLIDMNA----- 1191

  Fly  1115 AVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKS-EPYRRADAVRRSQRR 1167
                               :.||  .|.::.:|..|:| ..:||....|::.|:
Human  1192 -------------------EGDE--TGVMDSLLEALQSGAAFRRKRGPRQANRK 1224

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	59/283 (21%)
		Drf_FH3	374..567	CDD:461885	57/257 (22%)
		FH2	687..1063	CDD:396655	94/390 (24%)
DIAPH1	NP_005210.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..84
		Drf_GBD	84..268	CDD:461886	59/283 (21%)
		Drf_FH3	274..464	CDD:461885	40/192 (21%)
		SMC_prok_B	<429..>570	CDD:274008	29/141 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	573..755		42/181 (23%)
		Drf_FH1	590..>704	CDD:461881	27/113 (24%)
		FH2	769..1145	CDD:396655	94/389 (24%)