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Protein Alignment Frl and Grid2ip

DIOPT Version :10

Sequence 1:	NP_729954.2	Gene:	Frl / 39561	FlyBaseID:	FBgn0267795	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	NP_001152793.1	Gene:	Grid2ip / 170935	MGIID:	2176213	Length:	1203	Species:	Mus musculus

Alignment Length:	620	Identity:	148/620 - (23%)
Similarity:	246/620 - (39%)	Gaps:	130/620 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   482 SETKTSALERVQELEDQLEREIDRNSEFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQR 546
            |..|..|..|.....| .:|.:|..||.|.....:..:.||.:.:.|:::.
Mouse   655 SRRKLFAFSRPVRSRD-TDRFLDALSEQLGPRLSIVDDFLTPENDYEEMSF-------------- 704

  Fly   547 MLQHNEQELKKRDTLLHTKNMELQTLSRSLPRSASSGDGSLANGGLMAGSTSG----AASLTLPP 607
               |::|.             ...|..||   |||....|...|..:..|:..    ...|:.||
Mouse   705 ---HDDQG-------------SFVTNERS---SASECVSSSEEGSSLTYSSISDHIPPPPLSPPP 750

  Fly   608 PPP-----PMPASPTASSAAPPP--------------PPPPAPPAPPPPPGFSPLGSPSGSLAST 653
            |||     |.|:|.|:.....||              ||||.||.|||
Mouse   751 PPPLPFHDPKPSSRTSDGPRGPPQSLTKPLTQINHPVPPPPPPPLPPP----------------- 798

  Fly   654 APSPPHAPPMLSSFQPPPPPVAGFMPAPDGAMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNEL 718
               .|.||||||.       ..|...:....|::||          |.|..::.::  |||:.:|
Mouse   799 ---VPCAPPMLSR-------GVGHRRSETSHMSVKR----------LRWEQVENSE--GTIWGQL 841

  Fly   719 ----DDEKIFKQIDFNEFEERFKIGIGGALRNGSNGTE-----VDGSLQSSKRFKRPDNVSLLEH 774
                |.:|:...:.:.:.|..|             ||:     |.|    .:.|::.:.|.:|.|
Mouse   842 GEDSDYDKLSDMVKYLDLELHF-------------GTQKPPKPVPG----PEPFRKKEVVEILSH 889

  Fly   775 TRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQL 839
            .:..|.:|....|.:...::...:.|::.::|...::..|....|...|.:.|:.:   |:....
Mouse   890 KKAYNTSILLAHLKLTPGELRQVLMSMEPRRLEPAHLAQLLLFAPDADEEQRYQAF---REAPGR 951

  Fly   840 LTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVL 904
            |:|.|:|:||:..|....::|..:::.....:....|...::.:..||..||.|||...:||.||
Mouse   952 LSEPDQFVLQMLSVPEYKTRLRSLHFQATLQEKTEEIRGSLECLRQASLELKNSRKLAKILEFVL 1016

  Fly   905 AFGNYLNSN--KRGPAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTD 967
            |.|||||..  |.....|||:..|..|..||:.|.:|:.||.:..::...|||||.|..:|....
Mouse  1017 AMGNYLNDGQPKTNKTTGFKINFLTELNSTKTVDGKSTFLHILAKSLSQHFPELLGFAQDLPTVP 1081

  Fly   968 KAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTH---ILRDFLNNSEDKLKKIKSDLRHAQ 1029
            .||.|....:..|:.:|...:..::...:.....::..   ::..||..::..|:.:....|.|.
Mouse  1082 LAAKVNQRALTGDLADLHDTVSEIQVACQSMAPSSEDRFAVVMASFLETAQPALRALDGLQREAM 1146

  Fly  1030 EAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQ 1064
            |...:.:.:||:.|:...:.|||.:...|...|::
Mouse  1147 EELGKALAFFGEDSKATTSEAFFGIFSEFMSKFER 1181

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 592.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.