Protein Alignment Frl and FAM47B

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_689844.2
• Gene: FAM47B / 170062
• HGNCID: 26659
• Length: 645
• Species: Homo sapiens
• Alignment Length: 667
• Identity: 139/667 - (20%)
• Similarity: 216/667 - (32%)
• Gaps: 222/667 - (33%)

  Fly   493 QELEDQLEREIDRNSEFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQ----RMLQHNEQ 553
            |..||.|   :.|..|||.....|.......|:.:::| :.:..|..||:.:|    ..::..|.
Human    63 QSPEDTL---VCRRDEFLLPKISLRGPQADRKSRKKKL-LKKAALFSELSPVQPARKAFVEEVEA 123

  Fly   554 ELKKRDTLLHTKNME--------LQTLSRSLPR------------SASSGDGSLANGGLMAGSTS 598
            :|..:..|....|:.        ||.|.:..|.            ...:.:....:|....|.
Human   124 QLMTKHPLAMYPNLGKDMPPDLLLQVLKQLDPERKLEDAWARCEAREKTTEVPTESGKYPCGE-- 186

  Fly   599 GAASLTLPPPP--------PPMPASPTASSAAPPPP----------PP--------PAPP----- 632
                 :.|.||        |.:|.:| .||..|.||          ||        |.||
Human   187 -----SCPRPPETPVSRLRPQLPKTP-VSSRRPEPPKTRVSSLRPEPPKTRVSSLHPEPPETRAS 245

  Fly   633 ---APPPPPGFSPL--GSPSGSLASTAPSPP-----HAPPMLSSFQPPPPPVAGFMP-APDGAMT 686
               ..||..|.|.|  ..|...::|..|.||     |..|     :||...|:...| .|:..::
Human   246 HLRVDPPETGVSHLCPEPPKTLVSSVHPEPPDTGASHLCP-----EPPETRVSHLHPEPPETGVS 305

  Fly   687 IKRKVPTKYKLPTL---------NWIALK-PNQVRGTIF----NELDDEKIFKQIDFNEFEERFK 737
            ..|..|:|.::.:|         :.:.|: ||..|.:.|    .:||.||              |
Human   306 HLRPEPSKTQVSSLCPEPPEAGVSHLCLEPPNTHRVSSFLLQVLKLDSEK--------------K 356

  Fly   738 IGIGGALRNGSNGTEVD----GSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAI 798
            :....|...|...|..:    |.....:...||.. |.:.|.|| .:.|:||            :
Human   357 LEDARARCEGQEMTTEELTKPGKYHFWESCPRPFE-SRMPHLRL-VLPITRR------------M 407

  Fly   799 HSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIM 863
            .||.||......|..|.. .||.......||...|.....:....|    .|.| ...|.||...
Human   408 ASLCLKPPKTRRVSSLCP-EPTKTGASHLKELFQEDTPSTMECVSD----SLQR-RHTSRKLRDF 466

  Fly   864 NYMGNF------VDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIV--LAFGNYLN--------- 911
            .:.|:.      :.|:...:|:.:       :..|.:|.|...|..  |.:|..|:
Human   467 KWAGDLGVNEESISSLFDFTPECR-------TTDQDQKIKKANECASRLMYGMELDDMDEVEFLR 524

  Fly   912 ---------------SNKRG----------PAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRA 951
                           |.:||          |..|.||:|.:.|||.|...::..
Human   525 IKYWDRRRRAAPHSYSAQRGRIRYGPWYFEPKLGKKLRSDEPLIDPKPVLEKPD----------- 578

  Fly   952 KFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHILRDFLNNSED 1016
             .|::|:   .|||     .:|.::.:     |.||..:.....:|..|...|:
Human   579 -EPDILD---GLYG-----PIAFKDFI-----LSKGYRMPGVIEKLFAKKGWTY----------- 618

  Fly  1017 KLKKIKSDLRHAQEAFK 1033
              ..:|:.::.|.:.:|
Human   619 --DSVKTPIQRAVQVYK 633

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886
		Drf_FH3	374..567	CDD:461885	18/77 (23%)
		FH2	687..1063	CDD:396655	81/407 (20%)
FAM47B	NP_689844.2	FAM47	1..257	CDD:405345	44/205 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23
		PTZ00449	<167..377	CDD:185628	52/236 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..321		39/165 (24%)