DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Frl and FAM47B

DIOPT Version :9

Sequence 1:	NP_729954.2	Gene:	Frl / 39561	FlyBaseID:	FBgn0267795	Length:	1183	Species:	Drosophila melanogaster
Sequence 2:	NP_689844.2	Gene:	FAM47B / 170062	HGNCID:	26659	Length:	645	Species:	Homo sapiens

Alignment Length:	667	Identity:	139/667 - (20%)
Similarity:	216/667 - (32%)	Gaps:	222/667 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   493 QELEDQLEREIDRNSEFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQ----RMLQHNEQ 553
            |..||.|   :.|..|||.....|.......|:.:::| :.:..|..||:.:|    ..::..|.
Human    63 QSPEDTL---VCRRDEFLLPKISLRGPQADRKSRKKKL-LKKAALFSELSPVQPARKAFVEEVEA 123

  Fly   554 ELKKRDTLLHTKNME--------LQTLSRSLPR------------SASSGDGSLANGGLMAGSTS 598
            :|..:..|....|:.        ||.|.:..|.            ...:.:....:|....|.
Human   124 QLMTKHPLAMYPNLGKDMPPDLLLQVLKQLDPERKLEDAWARCEAREKTTEVPTESGKYPCGE-- 186

  Fly   599 GAASLTLPPPP--------PPMPASPTASSAAPPPP----------PP--------PAPP----- 632
                 :.|.||        |.:|.:| .||..|.||          ||        |.||
Human   187 -----SCPRPPETPVSRLRPQLPKTP-VSSRRPEPPKTRVSSLRPEPPKTRVSSLHPEPPETRAS 245

  Fly   633 ---APPPPPGFSPL--GSPSGSLASTAPSPP-----HAPPMLSSFQPPPPPVAGFMP-APDGAMT 686
               ..||..|.|.|  ..|...::|..|.||     |..|     :||...|:...| .|:..::
Human   246 HLRVDPPETGVSHLCPEPPKTLVSSVHPEPPDTGASHLCP-----EPPETRVSHLHPEPPETGVS 305

  Fly   687 IKRKVPTKYKLPTL---------NWIALK-PNQVRGTIF----NELDDEKIFKQIDFNEFEERFK 737
            ..|..|:|.::.:|         :.:.|: ||..|.:.|    .:||.||              |
Human   306 HLRPEPSKTQVSSLCPEPPEAGVSHLCLEPPNTHRVSSFLLQVLKLDSEK--------------K 356

  Fly   738 IGIGGALRNGSNGTEVD----GSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDVIAAI 798
            :....|...|...|..:    |.....:...||.. |.:.|.|| .:.|:||            :
Human   357 LEDARARCEGQEMTTEELTKPGKYHFWESCPRPFE-SRMPHLRL-VLPITRR------------M 407

  Fly   799 HSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIM 863
            .||.||......|..|.. .||.......||...|.....:....|    .|.| ...|.||...
Human   408 ASLCLKPPKTRRVSSLCP-EPTKTGASHLKELFQEDTPSTMECVSD----SLQR-RHTSRKLRDF 466

  Fly   864 NYMGNF------VDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIV--LAFGNYLN--------- 911
            .:.|:.      :.|:...:|:.:       :..|.:|.|...|..  |.:|..|:
Human   467 KWAGDLGVNEESISSLFDFTPECR-------TTDQDQKIKKANECASRLMYGMELDDMDEVEFLR 524

  Fly   912 ---------------SNKRG----------PAYGFKLQSLDTLIDTKSTDKRSSLLHYIVATIRA 951
                           |.:||          |..|.||:|.:.|||.|...::..
Human   525 IKYWDRRRRAAPHSYSAQRGRIRYGPWYFEPKLGKKLRSDEPLIDPKPVLEKPD----------- 578

  Fly   952 KFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHILRDFLNNSED 1016
             .|::|:   .|||     .:|.::.:     |.||..:.....:|..|...|:
Human   579 -EPDILD---GLYG-----PIAFKDFI-----LSKGYRMPGVIEKLFAKKGWTY----------- 618

  Fly  1017 KLKKIKSDLRHAQEAFK 1033
              ..:|:.::.|.:.:|
Human   619 --DSVKTPIQRAVQVYK 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920
		Drf_FH3	374..567	CDD:283917	18/77 (23%)
		FH2	687..1063	CDD:280362	81/407 (20%)
FAM47B	NP_689844.2	FAM47	1..258	CDD:291315	44/206 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..321		39/165 (24%)
		Drf_FH1	189..328	CDD:283903	37/144 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165156506
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930