DRSC/TRiP Functional Genomics Resources

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Protein Alignment Frl and Diaph1

DIOPT Version :9

Sequence 1:NP_729954.2 Gene:Frl / 39561 FlyBaseID:FBgn0267795 Length:1183 Species:Drosophila melanogaster
Sequence 2:NP_001292909.1 Gene:Diaph1 / 13367 MGIID:1194490 Length:1264 Species:Mus musculus


Alignment Length:1302 Identity:296/1302 - (22%)
Similarity:499/1302 - (38%) Gaps:403/1302 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 FAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHYLSKLRTYLDPK-ASRSHRLY 151
            |.::|..|:|..:|.:.||    ||  |::..:|||      |.||...:..::.| :|||..:|
Mouse    96 FEQMLVDMNLNEEKQQPLR----EK--DIVIKREMV------SQYLHTSKAGMNQKESSRSAMMY 148

  Fly   152 LFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQ 216
                :.:.|..:.:......|..|.:||..|.:.||:.|   ..:||.:|:|.|. ||    |::
Mouse   149 ----IQELRSGLRDMHLLSCLESLRVSLNNNPVSWVQTF---GAEGLASLLDILK-RL----HDE 201

  Fly   217 RLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMS 281
            :        ||                                        .:|..|||.||.: 
Mouse   202 K--------EE----------------------------------------TSGNYDSRNQHEI- 217

  Fly   282 YGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVIQHREAINC 346
                                                   |.||:|.||||:|...:::..|.|..
Mouse   218 ---------------------------------------IRCLKAFMNNKFGIKTMLETEEGILL 243

  Fly   347 IALSLIHKSLRTKALVLELLAAICLV---KGGHEIILGSFDNFKDVCQEKRRFQTLMEYFMNFEA 408
            :..::............:||:|:|::   :..:|.:|.:.....:: .|..|||.|::...:  .
Mouse   244 LVRAMDPAVPNMMIDAAKLLSALCI
LPQPEDMNERVLEAMTERAEM-DEVERFQPLLDGLKS--G 305

  Fly   409 FNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQISAY----- 468
            .:|...|.|:|.:|.::...|::::|||::.|...|||.:.|:.:|..|:|::|||:..:     
Mouse   306 TSIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQELREIENEDMKVQLCVFDEQGD 370

  Fly   469 ---------LDNV---------------------------------------------------- 472
                     ||::                                                    
Mouse   371 EDFFDLKGRLDDIRMEMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIE 435

  Fly   473 -----------------------FDVAAL---------MEDSETKTSALERVQELE----DQLER 501
                                   .|:..|         :|.||.|.:.||:..:.|    .:|:.
Mouse   436 ECVSQIVLHKNGTDPDFKCRHLQIDIERLVDQMIDKTKVEKSEAKATELEKKLDSELTARHELQV 500

  Fly   502 EIDR-NSEFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTK 565
            |:.: .::|..|..:|:.|...|.:|::|:...:|.||.|::.:...:....:||:      ..|
Mouse   501 EMKKMENDFEQKLQDLQGEKDALDSEKQQITAQKQDLEAEVSKLTGEVAKLSKELE------DAK 559

  Fly   566 NMELQTLSRSL--PRSASS----------GDGSLA----------NGGLMAGSTSGAASLTLPPP 608
            | |:.:||..:  |..:||          ||....          .||::..|........:|||
Mouse   560 N-EMASLSAVVVAPSVSSSAAVPPAPPLPGDSGTVIPPPPPPPPLPGGVVPPSPPLPPGTCIPPP 623

  Fly   609 PP-------PMPASPTASSAAPPPPP-------------------PPAPP------APPPPP--- 638
            ||       |.|.....|:|.|||||                   ||.||      .|||||   
Mouse   624 PPLPGGACIPPPPQLPGSAAIPPPPPLPGVASIPPPPPLPGATAIPPPPPLPGATAIPPPPPLPG 688

  Fly   639 --GFSPLGSP-SGSLASTAPSP----PHAPPMLSSFQ-----PPPPPVAGFMPAP---------- 681
              |..|...| .||:....|.|    |..||....|.     |||||..|..|.|          
Mouse   689 GTGIPPPPPPLPGSVGVPPPPPLPGGPGLPPPPPPFPGAPGIPPPPPGMGVPPPPPFGFGVPAAP 753

  Fly   682 --DGAMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFE--ERF-KIGIG 741
              ...:|.|:....:.:|...||...        :..:|..:..:.::..:.||  |.| |:.:.
Mouse   754 VLPFGLTPKKVYKPEVQLRRPNWSKF--------VAEDLSQDCFWTKVKEDRFENNELFAKLTLA 810

  Fly   742 GALRNGSNGTEVD---GSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMP---IDDVIAAIHS 800
            .:.:..::..:.|   |..:.|.:.|:...:.:|:....:|::|......||   |.:||..::.
Mouse   811 FSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNE 875

  Fly   801 LDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNY 865
            ..|.:..::|   |.|.:|...::|...|...|..|   |.|.::|.:.:..|.|:..:|..:.:
Mouse   876 AVLTESMIQN---LIKQMPEPEQLKMLSELKEEYDD---LAESEQFGVVMGTVPRLRPRLNAILF 934

  Fly   866 MGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGP-AYGFKLQSLDTL 929
            ...|.:.|..|.|::.|:..|...|::|..|.::||:.|..|||:|:..|.. |:||.:..|..|
Mouse   935 KLQFSEQVENIKPEIVSVTAACEELRKSENFSSLLELTLLVGNYMNAGSRNAGAFGFNISFLCKL 999

  Fly   930 IDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKE 994
            .||||.|::.:|||::........||:|.|..||...:||:.|:.||       |:|.:|.::|:
Mouse  1000 RDTKSADQKMTLLHFLAELCENDHPEVLKFPDELAHVEKASRVSAEN-------LQKSLDQMKKQ 1057

  Fly   995 AELRVKGAQTHILRDFLN-----NSEDK-LKKIKSDLRHAQE--------------AFKECVEYF 1039
            .        ..:.||..|     :.:|| ::|:.|.::.|||              .:||..:||
Mouse  1058 I--------ADVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGDYF 1114

  Fly  1040 GDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLE---KAAALAASKKENDQVLMRNKVNQKK 1101
            ....:......||..:..|...|.|..:||::|...|   :.|.||..|.|.:    |.:..||:
Mouse  1115 VFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKE----RLEKQQKR 1175

  Fly  1102 QQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKS-EPYRRADAVRRSQ 1165
            :||....|                        :.||  .|.::.:|..|:| ..:||....|:..
Mouse  1176 EQLIDMNA------------------------EGDE--TGVMDSLLEALQSGAAFRRKRGPRQVN 1214

  Fly  1166 RR 1167
            |:
Mouse  1215 RK 1216

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
FrlNP_729954.2 Drf_GBD 77..371 CDD:283920 60/283 (21%)
Drf_FH3 374..567 CDD:283917 54/295 (18%)
FH2 687..1063 CDD:280362 99/405 (24%)
Diaph1NP_001292909.1 Drf_GBD 84..268 CDD:283920 60/283 (21%)
Drf_FH3 274..464 CDD:283917 30/192 (16%)
Spc24 523..>557 CDD:285486 9/39 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 576..746 49/169 (29%)
FH2 762..1199 CDD:214697 120/495 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167846923
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000085
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3069
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.870

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