Protein Alignment Frl and Diaph1

DIOPT Version :10

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: NP_001292909.1
• Gene: Diaph1 / 13367
• MGIID: 1194490
• Length: 1264
• Species: Mus musculus
• Alignment Length: 1302
• Identity: 296/1302 - (22%)
• Similarity: 499/1302 - (38%)
• Gaps: 403/1302 - (30%)

  Fly    88 FAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHYLSKLRTYLDPK-ASRSHRLY 151
            |.::|..|:|..:|.:.||    ||  |::..:|||      |.||...:..::.| :|||..:|
Mouse    96 FEQMLVDMNLNEEKQQPLR----EK--DIVIKREMV------SQYLHTSKAGMNQKESSRSAMMY 148

  Fly   152 LFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQ 216
                :.:.|..:.:......|..|.:||..|.:.||:.|   ..:||.:|:|.|. ||    |::
Mouse   149 ----IQELRSGLRDMHLLSCLESLRVSLNNNPVSWVQTF---GAEGLASLLDILK-RL----HDE 201

  Fly   217 RLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMS 281
            :        ||                                        .:|..|||.||.:
Mouse   202 K--------EE----------------------------------------TSGNYDSRNQHEI- 217

  Fly   282 YGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVIQHREAINC 346
                                                   |.||:|.||||:|...:::..|.|..
Mouse   218 ---------------------------------------IRCLKAFMNNKFGIKTMLETEEGILL 243

  Fly   347 IALSLIHKSLRTKALVLELLAAICLV---KGGHEIILGSFDNFKDVCQEKRRFQTLMEYFMNFEA 408
            :..::............:||:|:|::   :..:|.:|.:.....:: .|..|||.|::...:  .
Mouse   244 LVRAMDPAVPNMMIDAAKLLSALCILPQPEDMNERVLEAMTERAEM-DEVERFQPLLDGLKS--G 305

  Fly   409 FNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQISAY----- 468
            .:|...|.|:|.:|.::...|::::|||::.|...|||.:.|:.:|..|:|::|||:..:
Mouse   306 TSIALKVGCLQLINALITPAEELDFRVHIRSELMRLGLHQVLQELREIENEDMKVQLCVFDEQGD 370

  Fly   469 ---------LDNV---------------------------------------------------- 472
                     ||::
Mouse   371 EDFFDLKGRLDDIRMEMDDFGEVFQIILNTVKDSKAEPHFLSILQHLLLVRNDYEARPQYYKLIE 435

  Fly   473 -----------------------FDVAAL---------MEDSETKTSALERVQELE----DQLER 501
                                   .|:..|         :|.||.|.:.||:..:.|    .:|:.
Mouse   436 ECVSQIVLHKNGTDPDFKCRHLQIDIERLVDQMIDKTKVEKSEAKATELEKKLDSELTARHELQV 500

  Fly   502 EIDR-NSEFLYKYAELESESLTLKTEREQLAMIRQKLEEELTVMQRMLQHNEQELKKRDTLLHTK 565
            |:.: .::|..|..:|:.|...|.:|::|:...:|.||.|::.:...:....:||:      ..|
Mouse   501 EMKKMENDFEQKLQDLQGEKDALDSEKQQITAQKQDLEAEVSKLTGEVAKLSKELE------DAK 559

  Fly   566 NMELQTLSRSL--PRSASS----------GDGSLA----------NGGLMAGSTSGAASLTLPPP 608
            | |:.:||..:  |..:||          ||....          .||::..|........:|||
Mouse   560 N-EMASLSAVVVAPSVSSSAAVPPAPPLPGDSGTVIPPPPPPPPLPGGVVPPSPPLPPGTCIPPP 623

  Fly   609 PP-------PMPASPTASSAAPPPPP-------------------PPAPP------APPPPP--- 638
            ||       |.|.....|:|.|||||                   ||.||      .|||||
Mouse   624 PPLPGGACIPPPPQLPGSAAIPPPPPLPGVASIPPPPPLPGATAIPPPPPLPGATAIPPPPPLPG 688

  Fly   639 --GFSPLGSP-SGSLASTAPSP----PHAPPMLSSFQ-----PPPPPVAGFMPAP---------- 681
              |..|...| .||:....|.|    |..||....|.     |||||..|..|.|
Mouse   689 GTGIPPPPPPLPGSVGVPPPPPLPGGPGLPPPPPPFPGAPGIPPPPPGMGVPPPPPFGFGVPAAP 753

  Fly   682 --DGAMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFE--ERF-KIGIG 741
              ...:|.|:....:.:|...||...        :..:|..:..:.::..:.||  |.| |:.:.
Mouse   754 VLPFGLTPKKVYKPEVQLRRPNWSKF--------VAEDLSQDCFWTKVKEDRFENNELFAKLTLA 810

  Fly   742 GALRNGSNGTEVD---GSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMP---IDDVIAAIHS 800
            .:.:..::..:.|   |..:.|.:.|:...:.:|:....:|::|......||   |.:||..::.
Mouse   811 FSAQTKTSKAKKDQEGGEEKKSVQKKKVKELKVLDSKTAQNLSIFLGSFRMPYQEIKNVILEVNE 875

  Fly   801 LDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNY 865
            ..|.:..::|   |.|.:|...::|...|...|..|   |.|.::|.:.:..|.|:..:|..:.:
Mouse   876 AVLTESMIQN---LIKQMPEPEQLKMLSELKEEYDD---LAESEQFGVVMGTVPRLRPRLNAILF 934

  Fly   866 MGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGP-AYGFKLQSLDTL 929
            ...|.:.|..|.|::.|:..|...|::|..|.::||:.|..|||:|:..|.. |:||.:..|..|
Mouse   935 KLQFSEQVENIKPEIVSVTAACEELRKSENFSSLLELTLLVGNYMNAGSRNAGAFGFNISFLCKL 999

  Fly   930 IDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKE 994
            .||||.|::.:|||::........||:|.|..||...:||:.|:.||       |:|.:|.::|:
Mouse  1000 RDTKSADQKMTLLHFLAELCENDHPEVLKFPDELAHVEKASRVSAEN-------LQKSLDQMKKQ 1057

  Fly   995 AELRVKGAQTHILRDFLN-----NSEDK-LKKIKSDLRHAQE--------------AFKECVEYF 1039
            .        ..:.||..|     :.:|| ::|:.|.::.|||              .:||..:||
Mouse  1058 I--------ADVERDVQNFPAATDEKDKFVEKMTSFVKDAQEQYNKLRMMHSNMETLYKELGDYF 1114

  Fly  1040 GDSSRNADAAAFFALIVRFTRAFKQHDQENEQRLRLE---KAAALAASKKENDQVLMRNKVNQKK 1101
            ....:......||..:..|...|.|..:||::|...|   :.|.||..|.|.:    |.:..||:
Mouse  1115 VFDPKKLSVEEFFMDLHNFRNMFLQAVKENQKRRETEEKMRRAKLAKEKAEKE----RLEKQQKR 1175

  Fly  1102 QQLPSNGALSLQEAVINELKSKAHSVREKKLLQQDEVYNGALEDILLGLKS-EPYRRADAVRRSQ 1165
            :||....|                        :.||  .|.::.:|..|:| ..:||....|:..
Mouse  1176 EQLIDMNA------------------------EGDE--TGVMDSLLEALQSGAAFRRKRGPRQVN 1214

  Fly  1166 RR 1167
            |:
Mouse  1215 RK 1216

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:461886	60/283 (21%)
		Drf_FH3	374..567	CDD:461885	54/295 (18%)
		FH2	687..1063	CDD:396655	99/405 (24%)
Diaph1	NP_001292909.1	Drf_GBD	88..268	CDD:461886	60/283 (21%)
		Drf_FH3	274..464	CDD:461885	30/192 (16%)
		SMC_prok_B	<429..>564	CDD:274008	27/141 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	576..746		49/169 (29%)
		FH2	761..1137	CDD:396655	99/404 (25%)