Protein Alignment Frl and fmnl1b

DIOPT Version :9

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: XP_009295890.3
• Gene: fmnl1b / 100536330
• ZFINID: ZDB-GENE-130306-1
• Length: 1026
• Species: Danio rerio
• Alignment Length: 1156
• Identity: 452/1156 - (39%)
• Similarity: 655/1156 - (56%)
• Gaps: 180/1156 - (15%)

  Fly    43 SSGTLQKQDLRYDIGCSSQYQHVRQPSLRSRSQQ-------PMPTTDELDRRFAKVLASMDLPPD 100
            ::|:|:...:|          .:::| |.:..|:       |.|:.:||:.||:.||.||:||||
Zfish     4 AAGSLEMSPVR----------EIKRP-LSTYGQKPPAAPKLPQPSEEELEERFSIVLNSMNLPPD 57

  Fly   101 KAKLLRNYDDEKKWDMICDQEMVQAKDPPSHYLSKLRTYLDPKASRSHRLYLFYFLCQKRKMVGE 165
            |..||..||.||||:::||||..|.|:|||.|:.||::.|:....|..          ||::
Zfish    58 KVMLLSQYDSEKKWELVCDQERFQVKNPPSAYIQKLKSVLEQGGGRKF----------KRRV--- 109

  Fly   166 STSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLSFRLQMMRHEQRLQGVLCASEERLN 230
            ..||||||:||||||||||.|.:|||::.|.|||.|||||||..:.:.::      :.:|.|
Zfish   110 QESTQVLRELEISLRTNHIGWAEEFLNEENNGLDVLVDYLSFAQRAVIYD------MDSSSE--- 165

  Fly   231 LTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGTLDSRQQHTMSYGFLRPTIADALDS 295
              ||....:.|...::|.:           ||..|.                   .|..|....:
Zfish   166 --NGSFEEKSVEDLTTSAT-----------NSPTHN-------------------SPRSARPFTT 198

  Fly   296 PSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNMVIQHREAINCIALSLIHKSLRTKA 360
            ....|.||.:::.|      .:|:.|||||||||.:.|||.|..|...:|.|.|||.::|.||||
Zfish   199 RKALRYSRMLSQNN------HLHLCIMCLRAIMNYQLGFNQVTAHPSCVNEITLSLNNRSARTKA 257

  Fly   361 LVLELLAAICLVKGGHEIILGSFDNFKDVCQEKRRFQTLMEYFMNFEAFNIDFMVACMQFMNIVV 425
            ||||||||:|||:||||:||.:|:||::||.||.||:.|||||.|.|: |||||||||||:||||
Zfish   258 LVLELLAAVCLVRGGHEMILAAFNNFREVCGEKNRFEKLMEYFRNEES-NIDFMVACMQFINIVV 321

  Fly   426 HSVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQISAYLDNVFDVAALMEDSETKTSALE 490
            |||||||:||.||||||.||||.|||::.:||||.|::||.|||||||||.|::||:|.|.:.:|
Zfish   322 HSVEDMNFRVFLQYEFTQLGLDSYLEKLNMTESERLQIQIQAYLDNVFDVGAMLEDAEAKNTLME 386

  Fly   491 RVQELEDQLEREIDRNSEFLYKYAELESESLTLKTEREQLAMIRQKLEEEL---TVMQRMLQHNE 552
            .::||::|       |::...:..:.|.|:|...|:.|| .:|:...:.||   :|.:..|..:.
Zfish   387 HLEELQEQ-------NTQLNTRLHQCEIEALEKTTDLEQ-QLIQSSKQVELLKESVKEVRLSSSS 443

  Fly   553 QELKKRDT---LLHTKNMELQT--------------LSRSLPRSASSGDGSLANGGLMAGSTSGA 600
            .....|.|   .:...:...||              :.|.|.|...|..|:|....:.|.:|:..
Zfish   444 FSSSSRRTDRRAVRPNSTHTQTDSRRRCRWRRCQLLVERGLIRMERSASGALDLHIIAAANTTDK 508

  Fly   601 ASLTLPPPPPPMPASPTASSAAPPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLS 665
            .|....|.|           .:|||||.||||.|||||   ||
Zfish   509 CSKETSPVP-----------QSPPPPPVPAPPPPPPPP---PL---------------------- 537

  Fly   666 SFQPPPPPVAGFMPAPDGAMTIKRKVPTKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFN 730
            :..||..|..|........:..|:.:.|||::|.|||.||...||.||:|.||||:.:.::::.:
Zfish   538 ALAPPTSPFIGRTGTIKTGVKGKQPIKTKYRMPLLNWQALMEEQVAGTVFTELDDQTVLQELNMD 602

  Fly   731 EFEERFKIGIGGALRNGSNGTEVD-GSLQSSKRFKRPDNVSLLEHTRLRNIAISRRKLGMPIDDV 794
            .|||.||        ..:....|| |:|:.....|....:||||..|.:|:||:.||.||....:
Zfish   603 VFEELFK--------TKAQSAPVDVGTLKVKVAQKASSKISLLEPNRAKNLAITLRKAGMSTAQI 659

  Fly   795 IAAIHSLDLKKLSLENVELLQKMVPTDAEVKSYKEYIIERKDQQL--LTEEDKFMLQLSRVERIS 857
            ..||.:.:|:.|..:.:|||::.||:|.|:|..:.|  ||..:.|  |:|||:||:..|::.|::
Zfish   660 CTAIQTYNLELLKSDFLELLERFVPSDYELKLIQNY--ERSGRPLVELSEEDRFMMAFSKIPRLT 722

  Fly   858 SKLAIMNYMGNFVDSVHLISPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFK 922
            .:::.:.:||:|.:||.::.||:.::..||.|::.|.|.|.:|||:||||||:||.|||.||||:
Zfish   723 QRISTLTFMGSFSESVLILKPQLNAVISASKSIRSSSKLKKILEIILAFGNYMNSGKRGSAYGFR 787

  Fly   923 LQSLDTLIDTKSTDKRSSLLHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKG 987
            |||||.|:|.||||::.:|||:||:.|:.|:|:|.||.:||:..||||.|:|::|::||..|:||
Zfish   788 LQSLDLLLDMKSTDRKQTLLHFIVSIIQDKYPQLSNFHTELHFLDKAALVSLDSVLSDVCSLQKG 852

  Fly   988 MDLVRKEAELRVKGAQTHILRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFF 1052
            ||:|.||.|   :...:.:|..|:..:...|..:..|...||||::..|||||::.::...:|||
Zfish   853 MDVVCKELE---QQQNSSVLTQFICTNRGLLDTLIKDSTTAQEAYQSVVEYFGENPKSTPPSAFF 914

  Fly  1053 ALIVRFTRAFKQHDQENEQRLRLEKAAALAASKKENDQVLMRNKVNQKKQQLPSNGALSLQEAVI 1117
            .:..||.:|:|..:||.:||.:....:...|..|.:|..:.|    ||..:||       |..:|
Zfish   915 PVFTRFIKAYKLCEQEIDQRRKRLSDSEETADLKFSDAPVHR----QKPLRLP-------QLDLI 968

  Fly  1118 NELKSKAHS--VREKKLLQQDEVYNGALEDILLGLKSEPYRRADAVRRSQR 1166
            :|||.:..|  |||.|        :||:|||:..|:::||.|||..|||.:
Zfish   969 SELKRRQMSPLVREGK--------DGAIEDIITDLRNQPYIRADGGRRSAK 1011

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	118/293 (40%)
		Drf_FH3	374..567	CDD:283917	98/198 (49%)
		FH2	687..1063	CDD:280362	157/378 (42%)
fmnl1b	XP_009295890.3	Drf_GBD	33..268	CDD:310750	118/294 (40%)
		Drf_FH3	271..437	CDD:310747	95/174 (55%)
		FH2	559..925	CDD:280362	157/378 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	344	1.000	Domainoid score	I1029
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D149905at33208
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.920