Protein Alignment Frl and fmnl2

DIOPT Version :9

• Sequence 1: NP_729954.2
• Gene: Frl / 39561
• FlyBaseID: FBgn0267795
• Length: 1183
• Species: Drosophila melanogaster
• Sequence 2: XP_012826322.1
• Gene: fmnl2 / 100491499
• XenbaseID: XB-GENE-1004377
• Length: 1106
• Species: Xenopus tropicalis
• Alignment Length: 1152
• Identity: 496/1152 - (43%)
• Similarity: 713/1152 - (61%)
• Gaps: 133/1152 - (11%)

  Fly    77 PMPTTDELDRRFAKVLASMDLPPDKAKLLRNYDDEKKWDMICDQEMVQAKDPPSHYLSKLRTYLD 141
            |||...||:.|||.||.:|:||||||:|||.||:||||::|||||..|.|:||..|:.||:.|||
 Frog    24 PMPEPGELEERFAIVLNAMNLPPDKARLLRQYDNEKKWELICDQERFQVKNPPHTYIQKLKGYLD 88

  Fly   142 PKASRSHRLYLFYFLCQKRKMVGESTSTQVLRDLEISLRTNHIEWVKEFLDDTNQGLDALVDYLS 206
            |...|.          :.|:.|.|  ||||||:||||||||||.||:|||::.|:|||.||:|||
 Frog    89 PAVPRK----------KFRRRVQE--STQVLRELEISLRTNHIGWVREFLNEENKGLDVLVEYLS 141

  Fly   207 FRLQMMRHEQRLQGVLCASEERLNLTNGGDGGEIVMGNSSSVSPGGGGGLLSHGNSTGHGLANGT 271
            |....:..:..     |...   |:.|..|..:   ..|.|:..      |..|::....:.|..
 Frog   142 FAQYAVTFDFE-----CLEN---NVENSVDKSK---PWSRSIED------LHRGSNLPSPVGNSI 189

  Fly   272 LDSRQQHTMSYGFLRPTIADALDSPSLKRRSRHIAKLNMGAATDDIHVSIMCLRAIMNNKYGFNM 336
            ..|.:..|:.|        :.|.|....:.||.::|      .||:||.|||||||||.:|||||
 Frog   190 TRSGRHSTLRY--------NTLPSRRTLKNSRLVSK------KDDVHVCIMCLRAIMNYQYGFNM 240

  Fly   337 VIQHREAINCIALSLIHKSLRTKALVLELLAAICLVKGGHEIILGSFDNFKDVCQEKRRFQTLME 401
            |:.|..|:|.|||||.:|:.||||||||||||:|||:|||||||.:|||||:||.||:||:.|||
 Frog   241 VMSHLHAVNEIALSLNNKNPRTKALVLELLAAVCLVRGGHEIILSAFDNFKEVCGEKQRFEKLME 305

  Fly   402 YFMNFEAFNIDFMVACMQFMNIVVHSVEDMNYRVHLQYEFTALGLDKYLERIRLTESEELKVQIS 466
            :|.| |..|||||||||||:|||||||||||:|||||:|||.|.||:||::::.|||::|:|||.
 Frog   306 HFRN-EDNNIDFMVACMQFINIVVHSVEDMNFRVHLQFEFTKLALDEYLDKLKHTESDKLQVQIQ 369

  Fly   467 AYLDNVFDVAALMEDSETKTSALERVQELEDQL----EREIDRNSEFLYKYAELESESLTLKTE- 526
            |||||||||.||:||:|||.:|||||:|||:.:    |:..|..:|.:.|..|||.:.:....|
 Frog   370 AYLDNVFDVGALLEDAETKNAALERVEELEENISHLSEKLQDTENEAMAKIVELEKQLMQRNKEL 434

  Fly   527 ---RE-------QLAMIRQKLEEELTVMQRM--LQHNEQELKKRDTLLHTK------NMELQTLS 573
               ||       |:..:|:.::|:...:||.  |:....||:|:.::...|      ::.....|
 Frog   435 DIAREVCKDANTQVHTLRKMVKEKEEAIQRQSTLERKIHELEKQGSIKIQKKGDGDISITPMVAS 499

  Fly   574 RSLPRSASSGDG-----SLANGGLMAGSTS-----GA-ASLTLPPPPPPMPAS------PTASSA 621
            .|:|..:....|     |::...:..|:||     || :|.||.||..|:..|      |.::.:
 Frog   500 GSVPSGSEGTPGGAPGASISGPSIPCGTTSVPGVAGALSSTTLVPPSSPLLGSSSVENGPVSAPS 564

  Fly   622 APPPPPPPAPPAPPPPPGFSPLGSPSGSLASTAPSPPHAPPMLSSFQPPPPPVAGFMPAPDGAMT 686
            .|||||||.||.|||||  .||.|....:....|.||.|||:..|..|.....:|....|....:
 Frog   565 PPPPPPPPPPPPPPPPP--PPLPSAEPPVPPPPPPPPGAPPLPGSASPTVIFNSGLADGPIKLFS 627

  Fly   687 IKRKVP--TKYKLPTLNWIALKPNQVRGTIFNELDDEKIFKQIDFNEFEERFKIGIGGALRNGSN 749
            :|.|.|  ||:::|..||:||||:|:.||:|||:|||:|.:.|:.:||||.||        ..:.
 Frog   628 VKIKKPIKTKFRMPVFNWVALKPHQINGTVFNEIDDERILEDINVDEFEEIFK--------TKAQ 684

  Fly   750 GTEVDGSLQSSKRFKRP---DNVSLLEHTRLRNIAISRRKLGMPIDDVIAAIHSLDLKKLSLENV 811
            |..:|  :.|:|:...|   ..|:|||..|.:|:||:.||.|...:::..||...|||.|.::.|
 Frog   685 GPAID--ISSTKQKAAPKVTSKVTLLEANRAKNLAITLRKAGKTAEEICKAIQLFDLKTLPVDFV 747

  Fly   812 ELLQKMVPTDAEVKSYKEYIIERKDQQLLTEEDKFMLQLSRVERISSKLAIMNYMGNFVDSVHLI 876
            |.|.:.:||:.|||.:::|..|:|..:.|::||:||:|.|::||:..|:.||.::|||.:|:.::
 Frog   748 ECLMRFMPTEGEVKVFRQYEREKKPLENLSDEDRFMMQFSKIERLMQKMTIMAFIGNFSESIQML 812

  Fly   877 SPQVQSIAGASTSLKQSRKFKAVLEIVLAFGNYLNSNKRGPAYGFKLQSLDTLIDTKSTDKRSSL 941
            :||:.:|..||.|:|.|:|.|.:|||:||.|||:||:|||..|||||||||.|:||||||::.:|
 Frog   813 TPQLHAIIAASVSIKSSQKLKKILEIILALGNYMNSSKRGAVYGFKLQSLDLLLDTKSTDRKQTL 877

  Fly   942 LHYIVATIRAKFPELLNFESELYGTDKAASVALENVVADVQELEKGMDLVRKEAELRVKGAQTHI 1006
            ||||...:|.|:.::..|.:|::..:|||:|:||||:.||:||::||||.::|..:.....   :
 Frog   878 LHYISNVVRDKYLQVALFYNEIHYVEKAAAVSLENVLLDVKELQRGMDLTKREYTMHDHNV---M 939

  Fly  1007 LRDFLNNSEDKLKKIKSDLRHAQEAFKECVEYFGDSSRNADAAAFFALIVRFTRAFKQHDQENEQ 1071
            |::|:.|||.:|||::.|.:.:|:||.:.|:|||::.:....:.||.:.|||.:|:|..|:|||.
 Frog   940 LKEFIQNSEVRLKKLQDDAKISQDAFDDVVKYFGENPKTTPPSVFFPVFVRFVKAYKNADEENEM 1004

  Fly  1072 RLRLEKAAALAASKKENDQVLMRN------KVNQKKQQLPSNGALSLQEAVINELKSKAHSVREK 1130
            |             |:.:|.||..      .:.|:.|:.||:.:...|:.:|.||       |.:
 Frog  1005 R-------------KKQEQALMEKLLEQEAMMEQQDQKSPSHKSKRQQQELIAEL-------RRR 1049

  Fly  1131 KLLQQDEVY---NGALEDILLGLKSEPYRRADAVRRSQRRRIDNNRL 1174
            ::.....||   :||:|||:..|:::||.||||:|||.|:|.|:..:
 Frog  1050 QVKDNRHVYEGKDGAIEDIITDLRNQPYIRADAMRRSVRKRFDDQNM 1096

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frl	NP_729954.2	Drf_GBD	77..371	CDD:283920	134/293 (46%)
		Drf_FH3	374..567	CDD:283917	110/215 (51%)
		FH2	687..1063	CDD:280362	165/380 (43%)
fmnl2	XP_012826322.1	Drf_GBD	23..275	CDD:283920	134/293 (46%)
		Drf_FH3	278..475	CDD:283917	106/197 (54%)
		FH2	630..981	CDD:280362	158/363 (44%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	337	1.000	Domainoid score	I1117
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H70871
Inparanoid	1	1.050	826	1.000	Inparanoid score	I452
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D149905at33208
OrthoFinder	1	1.000	-	-		FOG0000085
OrthoInspector	1	1.000	-	-		oto104271
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X513
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.060