Protein Alignment CG6833 and PAN2

DIOPT Version :10

• Sequence 1: NP_648689.1
• Gene: CG6833 / 39559
• FlyBaseID: FBgn0036405
• Length: 290
• Species: Drosophila melanogaster
• Sequence 2: NP_001120932.2
• Gene: PAN2 / 9924
• HGNCID: 20074
• Length: 1202
• Species: Homo sapiens
• Alignment Length: 232
• Identity: 61/232 - (26%)
• Similarity: 100/232 - (43%)
• Gaps: 59/232 - (25%)

  Fly    97 SAPLSKSARMRMKKKAHRNRILAMDCEMVGVGH----------------NTRDD----------- 134
            |..|::::..|.::|.|...|..|..||..:|.                ..|.|
Human   941 SVLLAEASLARKQRKTHTTFIPLMLNEMPQIGDLVGLDAEFVTLNEEEAELRSDGTKSTIKPSQM 1005

  Fly   135 MLARVSIVNRMGH----VLLDKYVKPRKEVTDYRTSVSGIRPQDI---ANGEDFAAVQNEVMKLI 192
            .:||::.|...|.    ..:|.|:..:::|.||.|..|||:|.|:   .:.:....:::..:||
Human  1006 SVARITCVRGQGPNEGIPFIDDYISTQEQVVDYLTQYSGIKPGDLDAKISSKHLTTLKSTYLKL- 1069

  Fly   193 HGRIL-------VGHGLRNDLAVLGIRHPFHDIRDTSH--YKPLCKLISNTHTPSLKRLTKAVLG 248
              |.|       |||||:.|..|:.:..|...:.||.:  :.|..::|      ||:.|....|.
Human  1070 --RFLIDIGVKFVGHGLQKDFRVINLMVPKDQVLDTVYLFHMPRKRMI------SLRFLAWYFLD 1126

  Fly   249 QEIQTGEHNSVEDARAAMGIYNRVAVDWEKYLEKKRH 285
            .:||...|:|:||||.|:.:|       .||||..::
Human  1127 LKIQGETHDSIEDARTALQLY-------RKYLELSKN 1156

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG6833	NP_648689.1	REX4_like	118..270	CDD:99847	50/194 (26%)
PAN2	NP_001120932.2	WD 1. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	153..193
		WD 2. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	195..231
		WD40	<204..357	CDD:475233
		WD 3. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	244..280
		WD 4. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	328..367
		Linker. /evidence=ECO:0000255|HAMAP-Rule:MF_03182	368..485
		UCH_1	517..898	CDD:463872
		PAN2_exo	975..1148	CDD:99846	47/188 (25%)