DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neurl4 and NEURL4

DIOPT Version :9

Sequence 1:	NP_648688.2	Gene:	Neurl4 / 39558	FlyBaseID:	FBgn0283503	Length:	1780	Species:	Drosophila melanogaster
Sequence 2:	NP_115818.2	Gene:	NEURL4 / 84461	HGNCID:	34410	Length:	1562	Species:	Homo sapiens

Alignment Length:	1903	Identity:	635/1903 - (33%)
Similarity:	878/1903 - (46%)	Gaps:	525/1903 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HTRCGRSIRLYNNNRMAQRSM--RDFSHALVFSAEPLEDDVLFEVVIEKKNTYWGGSIEIGVTAE 72
            |.|.||.:.|....|.|:|..  ::|:|.||.|.|||.|..:|.|.|::|...|.|||||||||.
Human    45 HPRTGRLVSLSACGRTARRQQPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTAL 109

  Fly    73 SPDDLELVACATAMRNGTWVMSGIDVRKDGRRLFEFYGTDLETLNENDRVGVMRTSGNDLVFYVN 137
            .|..|:..:.||.::.|:||:||..|.:|||.:.|.||.||:.|.|.|||||.||...:|..:||
Human   110 DPSVLDFPSSATGLKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLGEGDRVGVERTVAGELRLWVN 174

  Fly   138 GESQGVAAKNMPKPLWALVDLYGRCVQVSLCP----------------------------RDGSG 174
            |...||||..:|..:||:|||||:|.|:::.|                            ..|:.
Human   175 GRDCGVAATGLPPRVWAVVDLYGKCTQITVLPPEPGFSPPTPIPTPPLEPLAPTEDSALAEQGTS 239

  Fly   175 SGE-LLDSPLQ------------------QPLQQVVQNLDVA------MNVNIVVDSDAWMQGNG 214
            :.| .:.||.|                  ..|.:||.|..::      :|||:  .|....:|.|
Human   240 ADEAFMVSPAQARPETFPNSLESHNDFANMELSEVVSNTILSAYNGGLLNVNL--SSPPAGEGLG 302

  Fly   215 SVSGA--------DDRLCFHTRCGSLVKLSPNFRSAERRRPLDEFNNGVVMTHRPLRDNELFEIR 271
            | |||        :|.|.||.:||:|:|||.|.::|||||||||||||||||:|||||||:||||
Human   303 S-SGAATSPILTSNDALLFHEKCGTLIKLSNNNKTAERRRPLDEFNNGVVMTNRPLRDNEMFEIR 366

  Fly   272 IDKLVDKWSGSIEVGVTTHNPAVLHFPATMTNMRSGTIMMSGCGILTNGKGTRRQYGEFNLDELR 336
            |||||||||||||:|||||||..|.:||||||::||||||||||||||||||||:|.||:||||:
Human   367 IDKLVDKWSGSIEIGVTTHNPNSLEYPATMTNLQSGTIMMSGCGILTNGKGTRREYCEFSLDELQ 431

  Fly   337 EGDRVGMMRKANGNLHNYINGQDQGVAATRAPSTLWGVIDLYGMTIKVTIVDRDEREQQNLVTRR 401
            |||.:|:.||:|..||.:|||.|||||....|..::||:|||||.:|||||..:....:   .||
Human   432 EGDHIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKVTIVHNNNHSDR---LRR 493

  Fly   402 NNIVAGMTACSSGAGAQHTQHQQHSGTPTLSLLSPESEMNAAGAAGGLSETISSTRAIARNDDRL 466
            ||.:                         |..||||..:..|..|.            ....:||
Human   494 NNAI-------------------------LRALSPEGALRRAAPAA------------QAEPERL 521

  Fly   467 TFHHICGTHATVTQSGRTALRPNAADDFNNGVVLTRRPLRPNELFQVRLERVVTKWAGSVEMGVT 531
            .||..||..|.:|..|||||||:|.||||:||||:.|.||..|:||||::::|.|||||:|:|||
Human   522 LFHPNCGQKAAITHEGRTALRPHATDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVT 586

  Fly   532 THSADELDFPFTMTNVRSGTWMMTGNGVMQNGVTVIEQYGQNLDRLQVGDRVGVVRKDDGTLHFW 596
            ||:...|..|.||||:|||||||||||||.||.|::::||.|||||:.||.|||||::||||||:
Human   587 THNPAYLQLPSTMTNLRSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFF 651

  Fly   597 VNGVDQGPAANNVPERVYGVIDLYGQAAQASIVDTSECGS-PD---TGNSTISNTTLYSEV---P 654
            |||:.|||||.|||..||.|:|||||||||:|||..|... |:   .||:.:|.::..|..   .
Human   652 VNGMTQGPAAWNVPPGVYAVVDLYGQAAQATIVDDVEVAPVPEPLPEGNNQVSPSSPSSGAGGSD 716

  Fly   655 LRFHSIHGANAGISNSGLTASRPNSLAEFNDAIVFSNRPLRQRELFEVELETMVRHWSGNIEIGV 719
            ||||.:||:||.|:|.|.||.|.|..:|||||||.|||.||..||||:.::.||..|||:||.||
Human   717 LRFHQLHGSNAVITNGGRTALRHNCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGV 781

  Fly   720 TGTRPEDIQLAPNATDLEASDTIILCGPMIFHNRKTIRTNILLDLDTLGPSTRVGVMR--NGDFI 782
            |..||||::.....||:: .||.:|.|..|..:..|:|.|...|||.||...|:|:||  .|| :
Human   782 TAIRPEDLEFPNTMTDID-YDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTAKGD-L 844

  Fly   783 HFFVDGMDQGPACECHAP--NIWAIIDLYGQCAQVSLTQTQLDIRAPYATSENSQSCQATSVIQH 845
            |:|::|.|||.||....|  .::|::||||||.|||:|.....:....|||  :.:.:.:..:..
Human   845 HYFINGQDQGAACSGLPPGKEVYAVVDLYGQCVQVSITNATGPMDNSLATS--NTATEKSFPLHS 907

  Fly   846 PAMETKHRWTCVSG-NVSLTKDWTEASRFTGAAAPLSHCLVFSEHPLSVGSPFEIKLTSVNSMFA 909
            |.....||:....| ||:|.:|.|.|.|    ||..:|.||||...|.....||:|:..::..:|
Human   908 PVAGVAHRFHSTCGKNVTLEEDGTRAVR----AAGYAHGLVFSTKELRAEEVFEVKVEELDEKWA 968

  Fly   910 GCLSIGVTDLNLSDESV-----RKKLPTSIRRI-PANVWYVSGNEVCFNSSCLQRSL--ASLEWL 966
            |.|.:|:|.|...:...     ...||.|:..: ....|.||..||..:.. |||..  .:||.|
Human   969 GSLRLGLTTLAPGEMGPGAGGGGPGLPPSLPELRTKTTWMVSSCEVRRDGQ-LQRMNYGRNLERL 1032

  Fly   967 RVDDRITLER-VENSLNILLNSENVNIHFHNVPNDVYVVAELRGSTMGIQVISAQGPASPLRPCS 1030
            .|..|:.:.| .:::::||::.|::......:..:|:.|.:|.|...|:.::|           |
Human  1033 GVGSRVGVRRGADDTMHILVDGEDMGPAATGIAKNVWAVLDLYGPVRGVSIVS-----------S 1086

  Fly  1031 LRLQDSMDFGVDPLN-KQDSSMLESIDSEALNY---------------EFLDVSQKNARLSDDRR 1079
            .||::|.  |..|.: ..|:......|.|...:               |||:...||..||:..|
Human  1087 TRLEESE--GTQPPSPSSDTGSEGEEDDEGEEHGLGGQNEVGIIPTTLEFLENHGKNILLSNGNR 1149

  Fly  1080 SVTRIKSYNQSIVCLNKPLCKGESISIKVDALNNKWKGTVGLGVLSASPQTV--PISLLDFKRSC 1142
            :.||:.||||.||.:|:||.....:.:::|.||.:|..::.|||::.:|:.:  |.|....||:.
Human  1150 TATRVASYNQGIVVINQPLVPQLLVQVRIDFLNRQWTSSLVLGVITCAPERLNFPASACALKRAA 1214

  Fly  1143 WLATHDYVNINGQVMPSKYGDALEQIQVGTVITLTLTHAGMLIIMIGSTNLEDLASGLPNHVYPV 1207
            ||.....|..||..:..|:|..|:....||::.|.|..:|.|.:.:...:.......:|...:.:
Human  1215 WLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHVNGVDQGVAVPDVPQPCHAL 1279

  Fly  1208 FDVYGKCEKITLITGNDAGRTGNANGTPILEAPEALELDNGMPQQCEKAHLEMHEKEKDTEQVCE 1272
            .|:||:||::|::.......:|.:.||                             :.|.|:.
Human  1280 VDLYGQCEQVTIVNPEPGAASGKSAGT-----------------------------QGDMEKA-- 1313

  Fly  1273 SGPSTSGAPSNAMTRSVMESVSENLLLNISIKNRTLEQQRNELGGSSSTCCLRESLQLQHNTNLN 1337
                       .|...:.|||
Human  1314 -----------DMVDGIKESV-------------------------------------------- 1323

  Fly  1338 IQRSQSTQRFQNSLNTSATAAGSSGTSGCTANTQHLSNSGVYDTNKEYDDLPNPPNPLVNSVDEA 1402
                                        |.                      .||
Human  1324 ----------------------------CW----------------------GPP---------- 1328

  Fly  1403 SGAITSVSTTIDHSENNAEALELSASNEREMSGEPALNDNVLEDDEIDYMNHLLLLQQLQQNEYT 1467

Human  1329 ----------------------------------------------------------------- 1328

  Fly  1468 RHHLMPDQASLLNLDLPSLNSMESDTNSVGQTRPSGGTDSLRSTATGASVEQNDCEYLRQVRRFC 1532
                            |:.:.::|                              |||.....||.
Human  1329 ----------------PAASPLKS------------------------------CEYHALCSRFQ 1347

  Fly  1533 ASLVLPQAFFDSRLEP----VCFCLKCSGPSIGGNGDKLE--------------GWVYFKLNQQT 1579
            ..|:||:.:|   :.|    :|:|..|...    .||:..              ||..|.|.
Human  1348 ELLLLPEDYF---MPPPKRSLCYCESCRKL----RGDEAHRRRGEPPREYALPFGWCRFNLR--- 1402

  Fly  1580 VNV-LSTSTSTASAGGGASSATAPQVHFDLNGDWLPFYYMTRVDKIRAILDRGQ----------P 1633
            ||. |...|.|..                    |...|:.:.|..:|.:||||:          .
Human  1403 VNPRLEAGTLTKK--------------------WHMAYHGSNVAAVRRVLDRGELGAGTASILSC 1447

  Fly  1634 LPLETDPD---EEP---AAAALKDEPGTRL---ELYYSPNATVIEPVLPQHHFASEQGLHRISTS 1689
            .||:.:|.   |||   .|...:::|...|   .|.|:...|:...|  |......|..|:...:
Human  1448 RPLKGEPGVGFEEPGENCAPPREEQPPPVLLSPSLQYAGAETLASKV--QFRDPKSQRTHQAQVA 1510

  Fly  1690 FEVYVRRQSISGVTTGKAAAEAKRRSLGSTDHDHGGTGQGADGVGVTPSATLNESSVHLLNDLCW 1754
            |:|.||..|   .|.|..:|     :||.....|           .:|:            :|.|
Human  1511 FQVCVRPGS---YTPGPPSA-----ALGEPPDPH-----------FSPA------------ELEW 1544

  Fly  1755 FTKEAGACIINALIIKLD 1772
            .|||.||.::.||:::::
Human  1545 VTKEKGATLLCALLVRVE 1562

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neurl4	NP_648688.2	NEUZ	5..126	CDD:128856	56/117 (48%)
		SPRY_NHR_like	8..168	CDD:293945	76/159 (48%)
		NEUZ	221..345	CDD:128856	97/123 (79%)
		SPRY_NHR_like	225..387	CDD:293945	119/161 (74%)
		NEUZ	464..587	CDD:128856	78/122 (64%)
		SPRY_NHR_like	467..629	CDD:293945	107/161 (66%)
		NEUZ	653..777	CDD:128856	62/126 (49%)
		SPRY_NHR_like	656..818	CDD:293945	84/165 (51%)
		SPRY_NHR_like	854..1016	CDD:293945	50/171 (29%)
		SPRY_NHR_like	1063..1220	CDD:293945	52/158 (33%)
NEURL4	NP_115818.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..48		1/2 (50%)
		SPRY_NHR_like	43..205	CDD:293945	76/159 (48%)
		NEUZ	45..163	CDD:128856	56/117 (48%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	207..236		0/28 (0%)
		NEUZ	316..437	CDD:128856	96/120 (80%)
		SPRY_NHR_like	320..482	CDD:293945	119/161 (74%)
		NEUZ	520..642	CDD:128856	78/121 (64%)
		SPRY_NHR_like	523..684	CDD:293945	107/160 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	691..716		5/24 (21%)
		NEUZ	716..838	CDD:128856	62/122 (51%)
		SPRY_NHR_like	718..882	CDD:293945	84/165 (51%)
		SPRY_NHR_like	915..1084	CDD:293945	51/173 (29%)
		NEUZ	915..1042	CDD:128856	42/131 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1086..1123		9/38 (24%)
		NEUZ	1132..1247	CDD:128856	41/114 (36%)
		SPRY_NHR_like	1133..1292	CDD:293945	52/158 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158757
Domainoid	1	1.000	259	1.000	Domainoid score	I2000
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13029
Inparanoid	1	1.050	906	1.000	Inparanoid score	I372
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49525
OrthoDB	1	1.010	-	-		D491552at33208
OrthoFinder	1	1.000	-	-		FOG0007800
OrthoInspector	1	1.000	-	-		oto90417
orthoMCL	1	0.900	-	-		OOG6_108576
Panther	1	1.100	-	-	LDO	PTHR12429
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5748
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.910