DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neurl4 and neurl4

DIOPT Version :9

Sequence 1:	NP_648688.2	Gene:	Neurl4 / 39558	FlyBaseID:	FBgn0283503	Length:	1780	Species:	Drosophila melanogaster
Sequence 2:	XP_021335985.1	Gene:	neurl4 / 555331	ZFINID:	ZDB-GENE-100318-4	Length:	1588	Species:	Danio rerio

Alignment Length:	1964	Identity:	630/1964 - (32%)
Similarity:	880/1964 - (44%)	Gaps:	574/1964 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 AQSFHTRCGRSIRLYNNNRMAQRS--MRDFSHALVFSAEPLEDDVLFEVVIEKKNTYWGGSIEIG 68
            |...|.|.|:.|.|.|:||.|||:  :::|:|.||.|.|||.|..:|.|.|:||...|.||||||
Zfish     2 AAELHPRSGKLIGLSNSNRTAQRNQPVQEFNHGLVLSREPLRDRDVFTVRIDKKVNSWSGSIEIG 66

  Fly    69 VTAESPDDLELVACATAMRNGTWVMSGIDVRKDGRRLFEFYGTDLETLNENDRVGVMRTSGNDLV 133
            |||..|..||..:.||.::.|:|::||..|.||||.:.|.||.||:.|.|.||||:.|....:|.
Zfish    67 VTALDPAGLEFPSSATGLKGGSWIVSGCSVLKDGRSVLEEYGRDLDQLGEGDRVGIQRNGKGELH 131

  Fly   134 FYVNGESQGVAAKNMPKPLWALVDLYGRCVQVSL--C----PRDG-------------------- 172
            .:|||:..|.||..:|..|||:|||||:|.||::  |    ..:|
Zfish   132 LWVNGQDCGAAASGLPSRLWAVVDLYGKCTQVTVVSCEPPSEMEGDEDEEVEDEIVSTQAVSIMA 196

  Fly   173 -----------------------SGSGELL-------------------DSPL-QQPLQQVVQNL 194
                                   :||.|.:                   ||.| :..|..|..|.
Zfish   197 DACRSHDDRAAVLTAAAATTERMNGSAEEVPEVSRTHSRPDKFPNNFEPDSVLTEHQLFDVFNNA 261

  Fly   195 DVAM---------NVNI------------VVDSDAWMQGNGSVSG-------------------- 218
            .|::         ::|:            ...|:...:|.||.||
Zfish   262 IVSLYRSEDEGAEDLNVGGGGGGSDSSRGGTGSNGGGRGTGSDSGIGGGGGGGGSSSNSSPAGNA 326

  Fly   219 --------------ADDRLCFHTRCGSLVKLSPNFRSAERRRPLDEFNNGVVMTHRPLRDNELFE 269
                          .:|.|.||.:||:|:|||.|.::|||||||||||||||||:||||.||:||
Zfish   327 GGAAGLGVGTGGMTTNDALLFHEKCGTLIKLSNNNKTAERRRPLDEFNNGVVMTNRPLRHNEMFE 391

  Fly   270 IRIDKLVDKWSGSIEVGVTTHNPAVLHFPATMTNMRSGTIMMSGCGILTNGKGTRRQYGEFNLDE 334
            |||||||||||||||:|||||||..|.:||||||:|||||||||||||||||||||:|.||:|||
Zfish   392 IRIDKLVDKWSGSIEIGVTTHNPNNLDYPATMTNLRSGTIMMSGCGILTNGKGTRREYCEFSLDE 456

  Fly   335 LREGDRVGMMRKANGNLHNYINGQDQGVAATRAPSTLWGVIDLYGMTIKVTIVDRDEREQQNLVT 399
            |:|||.:|:||||:|.||.||||.||||||.:.|..::||:|||||.:|||||.......:   .
Zfish   457 LQEGDHIGLMRKASGALHFYINGIDQGVAANQTPGVVYGVVDLYGMAVKVTIVHNHNHSDR---L 518

  Fly   400 RRNNIVAGMTACSSGAGAQHTQHQQHSGTPTLSLLSPESEMNAAGAAGGLSETISSTRAIARNDD 464
            ||||.:  |.|.|...|...         |.|| |:||.::                      .|
Zfish   519 RRNNAI--MRALSPDVGRPR---------PALS-LTPEPDI----------------------PD 549

  Fly   465 RLTFHHICGTHATVTQSGRTALRPNAADDFNNGVVLTRRPLRPNELFQVRLERVVTKWAGSVEMG 529
            ||.||..||..|.:...|||||||:|.||||:||||:.|||..||:||||::::|.|||||:|:|
Zfish   550 RLLFHPNCGQKAAIISDGRTALRPHATDDFNHGVVLSNRPLHSNEVFQVRIDKMVDKWAGSIEIG 614

  Fly   530 VTTHSADELDFPFTMTNVRSGTWMMTGNGVMQNGVTVIEQYGQNLDRLQVGDRVGVVRKDDGTLH 594
            ||||:...|..|.||||:|||||||||||||.||.|::::||.|||||:.||.||||||:||:||
Zfish   615 VTTHNPAYLQLPSTMTNLRSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRKEDGSLH 679

  Fly   595 FWVNGVDQGPAANNVPERVYGVIDLYGQAAQASIV-----------DTSE------CGSPDTGNS 642
            |:||||.|||||.|||..||.|:|||||||||:|:           |:||      .|||    .
Zfish   680 FFVNGVPQGPAAWNVPPNVYAVVDLYGQAAQATIMDDMADLPPLPDDSSEGPTAMSPGSP----C 740

  Fly   643 TISNTTLYSEVPLRFHSIHGANAGISNSGLTASRPNSLAEFNDAIVFSNRPLRQRELFEVELETM 707
            :||..|..::  ||||.:||.||.|:|.|.||.|.|..:|||||||.|||.||:.||||:.::.|
Zfish   741 SISGATAAND--LRFHQLHGTNAVITNGGRTALRQNCRSEFNDAIVISNRCLREGELFEIVIQKM 803

  Fly   708 VRHWSGNIEIGVTGTRPEDIQLAPNATDLEASDTIILCGPMIFHNRKTIRTNILLDLDTLGPSTR 772
            |..|||:||.|||..|||:::.....||:: .||.:|.|..|..:..|:|.|...|||:|..::|
Zfish   804 VDRWSGSIEAGVTAIRPEELEFPNTMTDID-YDTWMLSGTAIMQDGNTMRNNYGCDLDSLTTASR 867

  Fly   773 VGVMR--NGDFIHFFVDGMDQGPACECHAPNIWAIIDLYGQCAQVSLTQTQLDIRAPYATSENSQ 835
            :|:||  .|| :|:|::|:|||.||......::|::||||||.|||:|.:...:.....||..::
Zfish   868 IGMMRTATGD-LHYFINGLDQGVACTGLPSEVYAVVDLYGQCVQVSITSSSGPLDNSLCTSNITE 931

  Fly   836 SCQATSVIQHPAMETKHRWTCVSG-NVSLTKDWTEASRFTGAAAPLSHCLVFSEHPLSVGSPFEI 899
            .   :..|..|.....||.....| ||.|..|..:|.|..|.|    |.:|||...|.....||:
Zfish   932 K---SFPIHSPVAGVAHRLHSKHGKNVVLLGDGCQALRVGGYA----HGIVFSAKELKTDEVFEV 989

  Fly   900 KLTSVNSMFAGCLSIGVTDLNLSDESVRKKLPT--------SIRRIPANV-WYVSGNEVCFNSSC 955
            |:..|:..::|.|.:|:|.|...|      ||:        |:.::...| |.::|:||..| ..
Zfish   990 KINKVDERWSGSLHVGLTTLQPPD------LPSCPLSGLSPSLTQLRTKVTWVLAGSEVRRN-GV 1047

  Fly   956 LQRSL--ASLEWLRVDDRITLERV-ENSLNILLNSENVNIHFHNVPNDVYVVAELRGSTMGIQVI 1017
            |||..  .||:.|.|.:|:.::|. :::::||::.|::......|..:||.|.:|.|....:.::
Zfish  1048 LQRQNYGCSLDRLTVGNRVGVKRCSDDTMHILIDGEDMGPAATAVAKNVYAVLDLYGKVTAVSIV 1112

  Fly  1018 SAQGPASPLRPCSLRLQDSMDFGVDPLN-------KQDSSMLESIDSE----ALNYEFLDVSQKN 1071
            |           |..::||.......|:       ::|.:.:...::|    .....||:...||
Zfish  1113 S-----------STLVEDSESVKAPSLSSDSCSEGEEDCTPVRECENEPPLVPTVMTFLENHGKN 1166

  Fly  1072 ARLSDDRRSVTRIKSYNQSIVCLNKPLCKGESISIKVDALNNKWKGTVGLGVLSASPQTV--PIS 1134
            .:||:...:..|:.||||.::...:.|.:.:....::|.||..|..::.|||:..||..:  |.:
Zfish  1167 IQLSNQNLTAARVSSYNQGLLVTAQALPRQQLFQFQIDRLNPSWTSSLSLGVIGHSPDRLNFPST 1231

  Fly  1135 LLDFKRSCWLATHDYVNINGQVMPSKYGDALEQIQVGTVITLTLTHAGMLIIMIGSTNLEDLASG 1199
            ....|||.||...|.|..|...:...||..|:....|||:.|.:..:|.|.:.:...:....|..
Zfish  1232 ACCLKRSVWLLQRDSVFHNSLKICENYGPNLDTCPEGTVLGLLVDSSGCLHLFVNGMDQGVAAQD 1296

  Fly  1200 LPNHVYPVFDVYGKCEKITLITGNDAGRTGNANGTPILEAPEALELDNGMPQQCEKAHLEMHEKE 1264
            :|:..|.:.|:||:||::|::          ||..|::
Zfish  1297 IPSPCYALIDLYGQCEQVTIV----------ANHVPVV--------------------------- 1324

  Fly  1265 KDTEQVCESGPSTSGAPSNAMTRSVMESVSENLLLNISIKNRTLEQQRNELGGSSSTCCLRESLQ 1329

Zfish  1325 ----------------------------------------------------------------- 1324

  Fly  1330 LQHNTNLNIQRSQSTQRFQNSLNTSATAAGSSGTSGCTANTQHLSNSGVYDTNKEYDDLPNPPNP 1394
                                        .|..|...|..:
Zfish  1325 ----------------------------GGERGDLRCQGD------------------------- 1336

  Fly  1395 LVNSVDEASGAITSVSTTIDHSENNAEALELSASNEREMSGEPALNDNVLEDDEIDYMNHLLLLQ 1459
             :...|...|...||..|                      ..|.:|.|
Zfish  1337 -MEKADMVDGIKESVCWT----------------------PPPEVNPN----------------- 1361

  Fly  1460 QLQQNEYTRHHLMPDQASLLNLDLPSLNSMESDTNSVGQTRPSGGTDSLRSTATGASVEQNDCEY 1524
                                                                        ..|||
Zfish  1362 ------------------------------------------------------------KTCEY 1366

  Fly  1525 LRQVRRFCASLVLPQAFF--DSRLEPVCFCLKCSGPSIGGNGDKLEG-WVYFKLNQQTVNVLSTS 1586
            .....||...|.||..:|  |::.. :|:|..|         .||.| ..|:|..:       ..
Zfish  1367 QALCSRFKDLLTLPDGYFNEDAKYN-LCYCESC---------HKLRGDEAYYKRGE-------PP 1414

  Fly  1587 TSTASAGGGASSATAPQVHFDLNG---DWLPFYYMTRVDKIRAILDRGQPLPLET---------- 1638
            ...|...|....|...:.|.:::.   .|...|:.|.|..:|..||..|.|..|:
Zfish  1415 RDYALPFGWCRFALQIKTHCEVSNAFKKWHIAYHGTSVGSLRRTLDHNQLLSAESSSIFSSSSVK 1479

  Fly  1639 --------DPDEEPAAAALKDEPGTRLELYYSPNATVIEPVLPQHHFASEQGL--HRISTSFEVY 1693
                    :|:|.  :|..:|.|  |::|..:...:.:|...|:..|...:.|  |:....|:|.
Zfish  1480 TEGHGSYGEPEEN--SAPERDIP--RVQLSPTMRYSGLEVFAPKVQFRDPRSLRCHQAQVGFQVC 1540

  Fly  1694 VRRQSISGVTTGKAAAEAKRRSLGSTDHDHGGTGQGADGVGVTPSATLNESSVHLLNDLCWFTKE 1758
            ||                           .|....|...:|::.......|:.    ::.|.|||
Zfish  1541 VR---------------------------PGSYKVGPSSLGISEPLDPRFSNA----EIEWITKE 1574

  Fly  1759 AGACIINALIIKLD 1772
            .|..::..|:|:::
Zfish  1575 KGGTLLYGLLIRVE 1588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neurl4	NP_648688.2	NEUZ	5..126	CDD:128856	61/121 (50%)
		SPRY_NHR_like	8..168	CDD:293945	80/163 (49%)
		NEUZ	221..345	CDD:128856	97/123 (79%)
		SPRY_NHR_like	225..387	CDD:293945	123/161 (76%)
		NEUZ	464..587	CDD:128856	79/122 (65%)
		SPRY_NHR_like	467..629	CDD:293945	108/161 (67%)
		NEUZ	653..777	CDD:128856	60/123 (49%)
		SPRY_NHR_like	656..818	CDD:293945	81/163 (50%)
		SPRY_NHR_like	854..1016	CDD:293945	51/174 (29%)
		SPRY_NHR_like	1063..1220	CDD:293945	48/158 (30%)
neurl4	XP_021335985.1	SPRY_NHR_like	4..166	CDD:293945	80/161 (50%)
		SPRY_NHR_like	347..509	CDD:293945	123/161 (76%)
		SPRY_NHR_like	553..713	CDD:293945	108/159 (68%)
		SPRY_NHR_like	752..914	CDD:293945	81/163 (50%)
		SPRY_NHR_like	946..1112	CDD:293945	52/176 (30%)
		SPRY_NHR_like	1158..1317	CDD:293945	48/158 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594710
Domainoid	1	1.000	266	1.000	Domainoid score	I1846
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13029
Inparanoid	1	1.050	970	1.000	Inparanoid score	I303
OMA	1	1.010	-	-		QHG49525
OrthoDB	1	1.010	-	-		D491552at33208
OrthoFinder	1	1.000	-	-		FOG0007800
OrthoInspector	1	1.000	-	-		oto40872
orthoMCL	1	0.900	-	-		OOG6_108576
Panther	1	1.100	-	-	LDO	PTHR12429
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5748
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	14	13.910