DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neurl4 and Neurl4

DIOPT Version :9

Sequence 1:	NP_648688.2	Gene:	Neurl4 / 39558	FlyBaseID:	FBgn0283503	Length:	1780	Species:	Drosophila melanogaster
Sequence 2:	XP_006246774.1	Gene:	Neurl4 / 303248	RGDID:	1308056	Length:	1563	Species:	Rattus norvegicus

Alignment Length:	1909	Identity:	635/1909 - (33%)
Similarity:	873/1909 - (45%)	Gaps:	538/1909 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HTRCGRSIRLYNNNRMAQRSM--RDFSHALVFSAEPLEDDVLFEVVIEKKNTYWGGSIEIGVTAE 72
            |.|.||.:.|....|.|:|..  ::|:|.||.|.|||.|..:|.|.|::|...|.|||||||||.
  Rat    47 HPRTGRLVSLSACGRTARRQQPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTAL 111

  Fly    73 SPDDLELVACATAMRNGTWVMSGIDVRKDGRRLFEFYGTDLETLNENDRVGVMRTSGNDLVFYVN 137
            .|..|:..:.||.::.|:||:||..|.:|||.:.|.||.||:.|.|.|||||.||:..:|..:||
  Rat   112 DPSVLDFPSSATGLKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLVEGDRVGVERTATGELRLWVN 176

  Fly   138 GESQGVAAKNMPKPLWALVDLYGRCVQVSLCPRDG------------------------SGSGEL 178
            |...||||..:|..:||:|||||:|.|:::.|.:.                        |..|..
  Rat   177 GRDCGVAATGLPARVWAVVDLYGKCTQITVLPPEPGFSPSTPISTPPLEPLAPPEDSALSEQGTS 241

  Fly   179 LD-----SPLQ------------------QPLQQVVQN----------LDVAMNVNIVVDSDAWM 210
            :|     ||.|                  ..|.:||.|          |:|:::.....|.   :
  Rat   242 VDEAFMVSPAQARPETFPNSLDSHNDFASMELSEVVSNAILSAYNGGLLNVSLSSPPAADG---L 303

  Fly   211 QGNGSVSG----ADDRLCFHTRCGSLVKLSPNFRSAERRRPLDEFNNGVVMTHRPLRDNELFEIR 271
            ..:||.:.    ::|.|.||.:||:|:|||.|.::|||||||||||||||||:|||||||:||||
  Rat   304 ASSGSATSPILTSNDALLFHEKCGTLIKLSNNNKTAERRRPLDEFNNGVVMTNRPLRDNEMFEIR 368

  Fly   272 IDKLVDKWSGSIEVGVTTHNPAVLHFPATMTNMRSGTIMMSGCGILTNGKGTRRQYGEFNLDELR 336
            |||||||||||||:|||||||..|.:||||||::||||||||||||||||||||:|.||:||||:
  Rat   369 IDKLVDKWSGSIEIGVTTHNPNSLEYPATMTNLQSGTIMMSGCGILTNGKGTRREYCEFSLDELQ 433

  Fly   337 EGDRVGMMRKANGNLHNYINGQDQGVAATRAPSTLWGVIDLYGMTIKVTIVDRDEREQQNLVTRR 401
            |||.:|:.||:|..||.:|||.|||||....|..::||:|||||.:|||||..:....:   .||
  Rat   434 EGDHIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKVTIVHNNNHSDR---LRR 495

  Fly   402 NNIVAGMTACSSGAGAQHTQHQQHSGTPTLSLLSPESEMNAAGAAGGLSETISSTRAIARNDDRL 466
            ||.:                         |..||||..:..|..|.            :...:||
  Rat   496 NNAI-------------------------LRALSPEGALRRAAPAA------------SAEPERL 523

  Fly   467 TFHHICGTHATVTQSGRTALRPNAADDFNNGVVLTRRPLRPNELFQVRLERVVTKWAGSVEMGVT 531
            .||..||..|.:|..|||||||:|.||||:||||:.|.||..|:||||::::|.|||||:|:|||
  Rat   524 LFHPNCGQKAAITHEGRTALRPHATDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVT 588

  Fly   532 THSADELDFPFTMTNVRSGTWMMTGNGVMQNGVTVIEQYGQNLDRLQVGDRVGVVRKDDGTLHFW 596
            ||:...|..|.||||:|||||||||||||.||.|::::||.|||||:.||.|||||::||||||:
  Rat   589 THNPAYLQLPSTMTNLRSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFF 653

  Fly   597 VNGVDQGPAANNVPERVYGVIDLYGQAAQASIVDTSE---CGSP-DTGNSTISNTTLYSEV---P 654
            |||:.|||||.|||..||.|:|||||||||:|||..|   ...| ..||:.:|.::..|.|   .
  Rat   654 VNGMTQGPAAWNVPPGVYAVVDLYGQAAQATIVDDVEVPPVSEPLPEGNNQMSPSSPASAVGGSD 718

  Fly   655 LRFHSIHGANAGISNSGLTASRPNSLAEFNDAIVFSNRPLRQRELFEVELETMVRHWSGNIEIGV 719
            ||||.:||:||.|:|.|.||.|.|..:|||||||.|||.||..||||:.::.||..|||:||.||
  Rat   719 LRFHQLHGSNAVITNGGRTALRHNCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGV 783

  Fly   720 TGTRPEDIQLAPNATDLEASDTIILCGPMIFHNRKTIRTNILLDLDTLGPSTRVGVMR--NGDFI 782
            |..||||::.....||:: .||.:|.|..|..:..|:|.|...|||.||...|:|:||  .|| :
  Rat   784 TAIRPEDLEFPNTMTDID-YDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTAKGD-L 846

  Fly   783 HFFVDGMDQGPACECHAP--NIWAIIDLYGQCAQVSLTQTQLDIRAPYATSENSQSCQATSVIQH 845
            |:|::|.|||.||....|  .::|::||||||.|||:|.....:....|||  :.:.:.:..:..
  Rat   847 HYFINGQDQGAACSGLPPGKEVYAVVDLYGQCVQVSITNATGPMDNSLATS--NTATEKSFPLHS 909

  Fly   846 PAMETKHRWTCVSG-NVSLTKDWTEASRFTGAAAPLSHCLVFSEHPLSVGSPFEIKLTSVNSMFA 909
            |.....||:....| ||:|.:|.|.|.|..|.|    |.||||...|.....||:|:..::..:|
  Rat   910 PVAGVAHRFHSTCGKNVTLEEDGTRAVRVAGYA----HGLVFSTKELKAEEVFEVKVEELDEKWA 970

  Fly   910 GCLSIGVTDLNLSD----ESVRKKLPTSIRRI-PANVWYVSGNEVCFNSSCLQRSL--ASLEWLR 967
            |.|.:|:|.|...|    ......||.|:..: ....|.||..|| .....|||..  .:||.|.
  Rat   971 GSLRLGLTTLAPEDMGPGAGSGPGLPPSLPELRTKTTWMVSSCEV-RRDGHLQRMNYGRNLERLG 1034

  Fly   968 VDDRITLER-VENSLNILLNSENVNIHFHNVPNDVYVVAELRGSTMGIQVISAQGPASPLRPCSL 1031
            |..|:.:.| .:::::||::.|::......:..:|:.|.:|.|....:.::|           |.
  Rat  1035 VGSRVGIRRCADDTMHILVDGEDMGPAATGIAKNVWAVLDLYGPVRSVAIVS-----------ST 1088

  Fly  1032 RLQDSMDFGVDPLNKQDSSMLESIDSE------------------ALNYEFLDVSQKNARLSDDR 1078
            ||::..  |..|.:....:..|..:.|                  ||  |||:...||..||:..
  Rat  1089 RLEEPE--GTQPPSPSSDTGSEGEEDEEGEEHGLRGQNQVGVMPTAL--EFLENHGKNILLSNGN 1149

  Fly  1079 RSVTRIKSYNQSIVCLNKPLCKGESISIKVDALNNKWKGTVGLGVLSASPQTV--PISLLDFKRS 1141
            |:.||:.||||.||.:::||.....:.:::|.||.:|..::.|||::..|:.:  |.|....||:
  Rat  1150 RTATRVASYNQGIVVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLNFPASACALKRA 1214

  Fly  1142 CWLATHDYVNINGQVMPSKYGDALEQIQVGTVITLTLTHAGMLIIMIGSTNLEDLASGLPNHVYP 1206
            .||.....|..||..:..|:|..|:....||::.|.|..:|.|.:.|...:.......:|...:.
  Rat  1215 AWLLRGRGVFHNGLKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHINGVDQGVAVPDVPQPCHA 1279

  Fly  1207 VFDVYGKCEKITLIT---GNDAGRTGNANGTPILEAPEALELDNGMPQQCEKAHLEMHEKEKDTE 1268
            :.|:||:||::|:::   |..:|:|....|                  ..|||.
  Rat  1280 LVDLYGQCEQVTIVSPDPGTASGKTAGTQG------------------DMEKAD----------- 1315

  Fly  1269 QVCESGPSTSGAPSNAMTRSVMESVSENLLLNISIKNRTLEQQRNELGGSSSTCCLRESLQLQHN 1333
                            |...:.|||
  Rat  1316 ----------------MVDGIKESV---------------------------------------- 1324

  Fly  1334 TNLNIQRSQSTQRFQNSLNTSATAAGSSGTSGCTANTQHLSNSGVYDTNKEYDDLPNPPNPLVNS 1398
                                            |.                      .||
  Rat  1325 --------------------------------CW----------------------GPP------ 1329

  Fly  1399 VDEASGAITSVSTTIDHSENNAEALELSASNEREMSGEPALNDNVLEDDEIDYMNHLLLLQQLQQ 1463

  Rat  1330 ----------------------------------------------------------------- 1329

  Fly  1464 NEYTRHHLMPDQASLLNLDLPSLNSMESDTNSVGQTRPSGGTDSLRSTATGASVEQNDCEYLRQV 1528
                                |:.:.::|                              |||....
  Rat  1330 --------------------PAASPLKS------------------------------CEYHALC 1344

  Fly  1529 RRFCASLVLPQAFFDSRLEP----VCFCLKCSGPSIGGNGDKLE--------------GWVYFKL 1575
            .||...|:||:.:|   :.|    :|:|..|...    .||:..              ||..|.|
  Rat  1345 SRFQELLLLPEDYF---MPPPKRSLCYCESCRKL----RGDEAHRRRGEPPREYALPFGWCRFNL 1402

  Fly  1576 NQQTVNV-LSTSTSTASAGGGASSATAPQVHFDLNGDWLPFYYMTRVDKIRAILDRGQ------- 1632
            .   ||. |...|.|..                    |...|:.:.|..:|.:||||:
  Rat  1403 R---VNPHLEAGTLTKK--------------------WHMAYHGSSVAVVRRVLDRGELGAGTTS 1444

  Fly  1633 ---PLPLETDPD---EEP---AAAALKDEPGTRL---ELYYSPNATVIEPVLPQHHFASEQGLHR 1685
               ..||:.:|.   |||   .|...:::|...|   .|.|:...|:...|  |......|..|:
  Rat  1445 ILSCRPLKGEPGVGFEEPGENCAPPREEQPPAVLLSPSLQYAGAETLASKV--QFRDPKSQRTHQ 1507

  Fly  1686 ISTSFEVYVRRQSISGVTTGKAAAEAKRRSLGSTDHDHGGTGQGADGVGVTPSATLNE-SSVHLL 1749
            ...:|:|.||..|   .|.|                              .|||.|.| ...|..
  Rat  1508 AQVAFQVCVRPGS---YTPG------------------------------PPSAALRELPDQHFS 1539

  Fly  1750 -NDLCWFTKEAGACIINALIIKLD 1772
             ::|.|.|||.||.::.||:::::
  Rat  1540 PSELEWVTKEKGATLLYALLVRVE 1563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neurl4	NP_648688.2	NEUZ	5..126	CDD:128856	56/117 (48%)
		SPRY_NHR_like	8..168	CDD:293945	76/159 (48%)
		NEUZ	221..345	CDD:128856	97/123 (79%)
		SPRY_NHR_like	225..387	CDD:293945	119/161 (74%)
		NEUZ	464..587	CDD:128856	78/122 (64%)
		SPRY_NHR_like	467..629	CDD:293945	107/161 (66%)
		NEUZ	653..777	CDD:128856	63/126 (50%)
		SPRY_NHR_like	656..818	CDD:293945	84/165 (51%)
		SPRY_NHR_like	854..1016	CDD:293945	50/170 (29%)
		SPRY_NHR_like	1063..1220	CDD:293945	52/158 (33%)
Neurl4	XP_006246774.1	SPRY_NHR_like	45..207	CDD:293945	76/161 (47%)
		NEUZ	47..165	CDD:128856	57/119 (48%)
		NEUZ	318..439	CDD:128856	76/120 (63%)
		SPRY_NHR_like	322..484	CDD:293945	81/161 (50%)
		NEUZ	522..644	CDD:128856	82/121 (68%)
		SPRY_NHR_like	525..686	CDD:293945	103/164 (63%)
		NEUZ	718..840	CDD:128856	60/125 (48%)
		SPRY_NHR_like	720..884	CDD:293945	73/167 (44%)
		SPRY_NHR_like	917..1085	CDD:293945	46/175 (26%)
		NEUZ	917..1043	CDD:128856	38/133 (29%)
		NEUZ	1131..1248	CDD:128856	31/118 (26%)
		SPRY_NHR_like	1134..1293	CDD:293945	41/163 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352764
Domainoid	1	1.000	259	1.000	Domainoid score	I1924
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13029
Inparanoid	1	1.050	908	1.000	Inparanoid score	I353
OMA	1	1.010	-	-		QHG49525
OrthoDB	1	1.010	-	-		D491552at33208
OrthoFinder	1	1.000	-	-		FOG0007800
OrthoInspector	1	1.000	-	-		oto97531
orthoMCL	1	0.900	-	-		OOG6_108576
Panther	1	1.100	-	-	LDO	PTHR12429
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5748
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910