DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Neurl4 and Neurl4

DIOPT Version :9

Sequence 1:	NP_648688.2	Gene:	Neurl4 / 39558	FlyBaseID:	FBgn0283503	Length:	1780	Species:	Drosophila melanogaster
Sequence 2:	NP_001013432.1	Gene:	Neurl4 / 216860	MGIID:	1921092	Length:	1563	Species:	Mus musculus

Alignment Length:	1894	Identity:	626/1894 - (33%)
Similarity:	864/1894 - (45%)	Gaps:	508/1894 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 HTRCGRSIRLYNNNRMAQRSM--RDFSHALVFSAEPLEDDVLFEVVIEKKNTYWGGSIEIGVTAE 72
            |.|.||.:.|....|.|:|..  ::|:|.||.|.|||.|..:|.|.|::|...|.|||||||||.
Mouse    47 HPRTGRLVSLSACGRTARRQQPGQEFNHGLVLSREPLRDGRVFTVRIDRKVNSWSGSIEIGVTAL 111

  Fly    73 SPDDLELVACATAMRNGTWVMSGIDVRKDGRRLFEFYGTDLETLNENDRVGVMRTSGNDLVFYVN 137
            .|..|:..:.||.::.|:||:||..|.:|||.:.|.||.||:.|.|.|||||.||:..:|..:||
Mouse   112 DPSVLDFPSSATGLKGGSWVVSGCSVLRDGRSVLEEYGQDLDQLVEGDRVGVERTATGELRLWVN 176

  Fly   138 GESQGVAAKNMPKPLWALVDLYGRCVQVSLCPRDGSGS------------------------GEL 178
            |...||||..:|..:||:|||||:|.|:::.|.:...|                        |..
Mouse   177 GRDCGVAATGLPARVWAVVDLYGKCTQITVLPSEPGFSPPTPVPTPPLEPLAPPEDSALLEQGTS 241

  Fly   179 LD-----SPLQQPLQQVVQNLD-----VAMNVNIVVDSDAWMQGNGSV----------------S 217
            :|     ||.|...:....:||     .:|.::.||.:......||.:                |
Mouse   242 VDEAFMVSPAQARPETFPNSLDSHNDFASMELSEVVSNAILSAYNGGLLNVSLSSPPAGDGLASS 306

  Fly   218 G--------ADDRLCFHTRCGSLVKLSPNFRSAERRRPLDEFNNGVVMTHRPLRDNELFEIRIDK 274
            |        ::|.|.||.:||:|:|||.|.::|||||||||||||||||:|||||||:|||||||
Mouse   307 GPATSPILTSNDALLFHEKCGTLIKLSNNNKTAERRRPLDEFNNGVVMTNRPLRDNEMFEIRIDK 371

  Fly   275 LVDKWSGSIEVGVTTHNPAVLHFPATMTNMRSGTIMMSGCGILTNGKGTRRQYGEFNLDELREGD 339
            ||||||||||:|||||||..|.:||||||::||||||||||||||||||||:|.||:||||:|||
Mouse   372 LVDKWSGSIEIGVTTHNPNSLEYPATMTNLQSGTIMMSGCGILTNGKGTRREYCEFSLDELQEGD 436

  Fly   340 RVGMMRKANGNLHNYINGQDQGVAATRAPSTLWGVIDLYGMTIKVTIVDRDEREQQNLVTRRNNI 404
            .:|:.||:|..||.:|||.|||||....|..::||:|||||.:|||||..:....:   .||||.
Mouse   437 HIGLTRKSNSALHFFINGIDQGVATPLTPPVVYGVVDLYGMAVKVTIVHNNNHSDR---LRRNNA 498

  Fly   405 VAGMTACSSGAGAQHTQHQQHSGTPTLSLLSPESEMNAAGAAGGLSETISSTRAIARNDDRLTFH 469
            :                         |..||||..:..|..|.            ....:||.||
Mouse   499 I-------------------------LRALSPEGALRRAAPAA------------QAEPERLLFH 526

  Fly   470 HICGTHATVTQSGRTALRPNAADDFNNGVVLTRRPLRPNELFQVRLERVVTKWAGSVEMGVTTHS 534
            ..||..|.:|..|||||||:|.||||:||||:.|.||..|:||||::::|.|||||:|:|||||:
Mouse   527 PNCGQKAAITHEGRTALRPHATDDFNHGVVLSSRALRDGEVFQVRIDKMVDKWAGSIEIGVTTHN 591

  Fly   535 ADELDFPFTMTNVRSGTWMMTGNGVMQNGVTVIEQYGQNLDRLQVGDRVGVVRKDDGTLHFWVNG 599
            ...|..|.||||:|||||||||||||.||.|::::||.|||||:.||.|||||::||||||:|||
Mouse   592 PAYLQLPSTMTNLRSGTWMMTGNGVMHNGTTILDEYGHNLDRLKAGDTVGVVRREDGTLHFFVNG 656

  Fly   600 VDQGPAANNVPERVYGVIDLYGQAAQASIVDTSE---CGSP-DTGNSTISNTTLYSEV---PLRF 657
            :.|||||.|||..||.|:|||||||||:|||..|   ...| ..||:.:|.::..|..   .|||
Mouse   657 MTQGPAAWNVPPGVYAVVDLYGQAAQATIVDDVEVPPVSEPLPEGNNQMSPSSPSSAAGGSDLRF 721

  Fly   658 HSIHGANAGISNSGLTASRPNSLAEFNDAIVFSNRPLRQRELFEVELETMVRHWSGNIEIGVTGT 722
            |.:||:||.|:|.|.||.|.|..:|||||||.|||.||..||||:.::.||..|||:||.|||..
Mouse   722 HQLHGSNAVITNGGRTALRHNCRSEFNDAIVISNRALRDGELFEIVIQKMVDRWSGSIEAGVTAI 786

  Fly   723 RPEDIQLAPNATDLEASDTIILCGPMIFHNRKTIRTNILLDLDTLGPSTRVGVMR--NGDFIHFF 785
            ||||::.....||:: .||.:|.|..|..:..|:|.|...|||.||...|:|:||  .|| :|:|
Mouse   787 RPEDLEFPNTMTDID-YDTWMLSGTAIMQDGNTMRNNYGCDLDALGTGARIGMMRTAKGD-LHYF 849

  Fly   786 VDGMDQGPACECHAP--NIWAIIDLYGQCAQVSLTQTQLDIRAPYATSENSQSCQATSVIQHPAM 848
            ::|.|||.||....|  .::|::||||||.|||:|.....:....|||  :.:.:.:..:..|..
Mouse   850 INGQDQGAACSGLPPGKEVYAVVDLYGQCVQVSITNATGPMDNSLATS--NTATEKSFPLHSPVA 912

  Fly   849 ETKHRWTCVSG-NVSLTKDWTEASRFTGAAAPLSHCLVFSEHPLSVGSPFEIKLTSVNSMFAGCL 912
            ...||:..:.| ||:|.:|.|.|.|..|.|    |.||||...|.....||:|:..::..:||.|
Mouse   913 GVAHRFHSMCGKNVTLEEDGTRAVRVAGYA----HGLVFSTKELKAEEVFEVKVEELDEKWAGSL 973

  Fly   913 SIGVTDLNLSD----ESVRKKLPTSIRRI-PANVWYVSGNEVCFNSSCLQRSL--ASLEWLRVDD 970
            .:|:|.|...|    ......||.|:..: ....|.||..|| .....|||..  .:||.|.|..
Mouse   974 RLGLTTLAPEDMGPGAGSGPGLPPSLPELRTKTTWMVSSCEV-RRDGHLQRMNYGRNLERLGVGS 1037

  Fly   971 RITLER-VENSLNILLNSENVNIHFHNVPNDVYVVAELRGSTMGIQVISA------QG--PASPL 1026
            |:.:.| .:::::||::.|::......:..:|:.|.:|.|....:.::|:      :|  |.||.
Mouse  1038 RVGIRRCADDTMHILVDGEDMGPAAAGIAKNVWAVLDLYGPVRSVAIVSSTRLEEPEGTQPPSPS 1102

  Fly  1027 RPCSLRLQDSMDFGVDPLNKQDSSMLESIDSEALNYEFLDVSQKNARLSDDRRSVTRIKSYNQSI 1091
            ......:::.     |.:.:|.......:.......|||:...||..||:..|:.||:.||||.|
Mouse  1103 SDTGSEVEED-----DEVEEQGLRGQNQVGIVPTALEFLENHGKNILLSNGNRTATRVASYNQGI 1162

  Fly  1092 VCLNKPLCKGESISIKVDALNNKWKGTVGLGVLSASPQTV--PISLLDFKRSCWLATHDYVNING 1154
            |.:::||.....:.:::|.||.:|..::.|||::..|:.:  |.|....||:.||.....|..||
Mouse  1163 VVISQPLVPHMLVQVRIDFLNRQWTSSLVLGVITCPPERLNFPASACALKRAAWLLRGRGVFHNG 1227

  Fly  1155 QVMPSKYGDALEQIQVGTVITLTLTHAGMLIIMIGSTNLEDLASGLPNHVYPVFDVYGKCEKITL 1219
            ..:..|:|..|:....||::.|.|..:|.|.:.|...:.......:|...:.:.|:||:||::|:
Mouse  1228 LKICEKFGPNLDTCPEGTILGLRLDSSGGLHLHINGVDQGVAVPDVPQPCHALVDLYGQCEQVTI 1292

  Fly  1220 ITGNDAGRTGNANGTPILEAPEALELDNGMPQQCEKAHLEMHEKEKDTEQVCESGPSTSGAPSNA 1284
            ::.:....:|...||                             :.|.|:.             .
Mouse  1293 VSPDPGTASGKIAGT-----------------------------QGDMEKA-------------D 1315

  Fly  1285 MTRSVMESVSENLLLNISIKNRTLEQQRNELGGSSSTCCLRESLQLQHNTNLNIQRSQSTQRFQN 1349
            |...:.|||
Mouse  1316 MVDGIKESV-------------------------------------------------------- 1324

  Fly  1350 SLNTSATAAGSSGTSGCTANTQHLSNSGVYDTNKEYDDLPNPPNPLVNSVDEASGAITSVSTTID 1414
                            |.                      .||
Mouse  1325 ----------------CW----------------------GPP---------------------- 1329

  Fly  1415 HSENNAEALELSASNEREMSGEPALNDNVLEDDEIDYMNHLLLLQQLQQNEYTRHHLMPDQASLL 1479

Mouse  1330 ----------------------------------------------------------------- 1329

  Fly  1480 NLDLPSLNSMESDTNSVGQTRPSGGTDSLRSTATGASVEQNDCEYLRQVRRFCASLVLPQAFFDS 1544
                |:.:.::|                              |||.....||...|:||:.:|
Mouse  1330 ----PAASPLKS------------------------------CEYHALCSRFQELLLLPEDYF-- 1358

  Fly  1545 RLEP----VCFCLKCSGPSIGGNGDKLE--------------GWVYFKLNQQTVNV-LSTSTSTA 1590
             :.|    :|:|..|...    .||:..              ||..|.|.   ||. |...|.|.
Mouse  1359 -MPPPKRSLCYCESCRKL----RGDEAHRRRGEPPREYALPFGWCRFNLR---VNPHLEAGTLTK 1415

  Fly  1591 SAGGGASSATAPQVHFDLNGDWLPFYYMTRVDKIRAILDRGQPLPLETDPDEEPAAAALKDEPGT 1655
            .                    |...|:.:.|..:|.:||||:   |........:...||.|||.
Mouse  1416 K--------------------WHMAYHGSSVAVVRRVLDRGE---LGAGTTSILSCRPLKGEPGV 1457

  Fly  1656 RLE---------LYYSPNATVIEPVLP-----------QHHFASEQGLHRISTSFEVYVRRQSIS 1700
            ..|         ....|...::.|.|.           |......|..|:...:|:|.||..|
Mouse  1458 GFEEPGENCAPPREEQPPPVLLSPSLQYAGAEMLASKVQFRDPKSQRTHQAQVAFQVCVRPGS-- 1520

  Fly  1701 GVTTGKAAAEAKRRSLGSTDHDHGGTGQGADGVGVTPSATLNE-SSVHLL-NDLCWFTKEAGACI 1763
             .|.|                              .|||.|.| ...|.. ::|.|.|||.||.:
Mouse  1521 -YTPG------------------------------PPSAALRELPDQHFSPSELEWVTKEKGATL 1554

  Fly  1764 INALIIKLD 1772
            :.||:::::
Mouse  1555 LYALLVRVE 1563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neurl4	NP_648688.2	NEUZ	5..126	CDD:128856	56/117 (48%)
		SPRY_NHR_like	8..168	CDD:293945	76/159 (48%)
		NEUZ	221..345	CDD:128856	97/123 (79%)
		SPRY_NHR_like	225..387	CDD:293945	119/161 (74%)
		NEUZ	464..587	CDD:128856	78/122 (64%)
		SPRY_NHR_like	467..629	CDD:293945	107/161 (66%)
		NEUZ	653..777	CDD:128856	62/126 (49%)
		SPRY_NHR_like	656..818	CDD:293945	84/165 (51%)
		SPRY_NHR_like	854..1016	CDD:293945	50/170 (29%)
		SPRY_NHR_like	1063..1220	CDD:293945	52/158 (33%)
Neurl4	NP_001013432.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		1/1 (100%)
		SPRY_NHR_like	45..207	CDD:293945	76/161 (47%)
		NEUZ	47..165	CDD:128856	57/119 (48%)
		NEUZ	318..439	CDD:128856	76/120 (63%)
		SPRY_NHR_like	322..484	CDD:293945	81/161 (50%)
		NEUZ	522..644	CDD:128856	82/121 (68%)
		SPRY_NHR_like	525..686	CDD:293945	103/164 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	692..717		15/24 (63%)
		NEUZ	718..840	CDD:128856	60/125 (48%)
		SPRY_NHR_like	720..884	CDD:293945	73/167 (44%)
		SPRY_NHR_like	917..1085	CDD:293945	46/183 (25%)
		NEUZ	917..1043	CDD:128856	38/133 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1087..1121		9/33 (27%)
		NEUZ	1131..1248	CDD:128856	31/118 (26%)
		SPRY_NHR_like	1134..1293	CDD:293945	39/160 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849150
Domainoid	1	1.000	259	1.000	Domainoid score	I1988
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H13029
Inparanoid	1	1.050	902	1.000	Inparanoid score	I375
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49525
OrthoDB	1	1.010	-	-		D491552at33208
OrthoFinder	1	1.000	-	-		FOG0007800
OrthoInspector	1	1.000	-	-		oto94002
orthoMCL	1	0.900	-	-		OOG6_108576
Panther	1	1.100	-	-	LDO	PTHR12429
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X5748
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	12.910