DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Neurl4 and neurl2

DIOPT Version :9

Sequence 1:	NP_648688.2	Gene:	Neurl4 / 39558	FlyBaseID:	FBgn0283503	Length:	1780	Species:	Drosophila melanogaster
Sequence 2:	XP_002932555.2	Gene:	neurl2 / 100494896	XenbaseID:	XB-GENE-1010743	Length:	274	Species:	Xenopus tropicalis

Alignment Length:	268	Identity:	63/268 - (23%)
Similarity:	109/268 - (40%)	Gaps:	72/268 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   450 SETISSTRAIARNDDRLTFHHICGTHATVTQSGRTALRPNAADDFNNGVVLTRRPLRPNELFQVR 514
            :|..:.|.|: :....::||||.|.:..:..||..|.|   .:.|.||:..::.||:|.::|.|.
Frog     3 AEIFTGTMAV-QCQPFMSFHHIHGANVRIDPSGTLATR---VESFANGICFSQEPLQPGQIFLVE 63

  Fly   515 LERVVTKWAGSVEMGVTTHSADELDF--PFTMTNV--RSGTWM--MTGNGVMQNGVTVIE----- 568
            :|.....|.|.:.:|:.......||.  .:::.::  ..|:|:  :|.|   .|.|...|
Frog    64 IEDKELGWCGHLRVGLMARDPHNLDVVPEYSLPDLVNEGGSWIFAITRN---HNKVQTEEDSNTI 125

  Fly   569 ------------------------------QYGQNLDRL---------QVGDRVGVV--RKDDGT 592
                                          ::...||.|         .:..|:||:  .:.|||
Frog   126 AIKGLLADPYLKVGKFKYPREKLVARSRPGRFSHILDELYKSNVLPPTALRSRIGVLYEPQSDGT 190

  Fly   593 --LHFWVNGVDQGPAANNVP--ERVYGVIDLYGQAAQASIVDTSECGSPDTGNSTISNTTLYSEV 653
              :|..:||.|.||:|..:|  |.:|.|||::.......::.. |.|.|       |..|| ..:
Frog   191 RNMHIIINGEDMGPSAKGIPATEPLYAVIDVFASTKSVRVIQL-EYGFP-------SLQTL-CRL 246

  Fly   654 PLRFHSIH 661
            .::.|.:|
Frog   247 VIQKHIVH 254

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Neurl4	NP_648688.2	NEUZ	5..126	CDD:128856
		SPRY_NHR_like	8..168	CDD:293945
		NEUZ	221..345	CDD:128856
		SPRY_NHR_like	225..387	CDD:293945
		NEUZ	464..587	CDD:128856	36/174 (21%)
		SPRY_NHR_like	467..629	CDD:293945	52/217 (24%)
		NEUZ	653..777	CDD:128856	2/9 (22%)
		SPRY_NHR_like	656..818	CDD:293945	2/6 (33%)
		SPRY_NHR_like	854..1016	CDD:293945
		SPRY_NHR_like	1063..1220	CDD:293945
neurl2	XP_002932555.2	SPRY_NHR_like	19..231	CDD:293945	52/217 (24%)
neurl2	XP_002932555.2	SOCS_box	238..274	CDD:198037	6/25 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D491552at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010